{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T04:17:21Z","timestamp":1783052241090,"version":"3.54.6"},"update-to":[{"DOI":"10.1371\/journal.pntd.0012264","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000}}],"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Culture and Science of the State of North Rhine-Westphalia","award":["323-8.03-151826"],"award-info":[{"award-number":["323-8.03-151826"]}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01KI2106"],"award-info":[{"award-number":["01KI2106"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003107","name":"Federal Ministry of Health","doi-asserted-by":"crossref","award":["ZMVI1-2516FSB416"],"award-info":[{"award-number":["ZMVI1-2516FSB416"]}],"id":[{"id":"10.13039\/501100003107","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>Despite continued outbreaks of yellow fever virus (YFV) in endemic regions, data on its environmental stability or guidelines for its effective inactivation is limited. Here, we evaluated the susceptibility of the YFV 17D vaccine strain to inactivation by ethanol, 2-propanol, World Health Organization (WHO)-recommended hand rub formulations I and II, as well as surface disinfectants. In addition, two pathogenic strains were tested to compare inactivation kinetics by WHO-recommended hand rub formulations I and II. Furthermore, environmental stability of the vaccine strain was assessed. YFV 17D particles displayed infectivity half-life decay profiles of ~13 days at room temperature. Despite this extended environmental stability, YFV was efficiently inactivated by alcohols, WHO-recommended hand formulations, and four out of five tested surface disinfectants. These results are useful in defining disinfection protocols to prevent non-vector borne YFV transmission.<\/jats:p>","DOI":"10.1371\/journal.pntd.0012264","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T17:42:17Z","timestamp":1718905337000},"page":"e0012264","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Inactivation of yellow fever virus by WHO-recommended hand rub formulations and surface disinfectants"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8962-9443","authenticated-orcid":true,"given":"Toni Luise","family":"Meister","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Frericks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin D. 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Epidemiological Update: Yellow Fever. 2018. https:\/\/www3.paho.org\/hq\/index.php?option=com_docman&view=download&category_slug=yellow-fever-2194&alias=44111-20-march-2018-yellow-fever-epidemiological-update-111&Itemid=270&lang=en."},{"key":"pntd.0012264.ref011","article-title":"Yellow Fever: Integrating Current Knowledge with Technological Innovations to Identify Strategies for Controlling a Re-Emerging Virus","volume":"11","author":"RDV Kleinert","year":"2019","journal-title":"Viruses"},{"key":"pntd.0012264.ref012","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1136\/bmj.1.3655.125","article-title":"Observations on LABORATORY AND HOSPITAL INFECTIONS WITH YELLOW FEVER IN ENGLAND","volume":"1","author":"GC Low","year":"1931","journal-title":"Br Med J"},{"key":"pntd.0012264.ref013","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/0035-9203(94)90244-5","article-title":"Fatal yellow fever contracted at the Hospital for Tropical Diseases, London, UK, in 1930","volume":"88","author":"GC Cook","year":"1994","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"pntd.0012264.ref014","doi-asserted-by":"crossref","first-page":"E243","DOI":"10.1503\/cmaj.100619","article-title":"Case report: probable transmission of vaccine strain of yellow fever virus to an infant via breast milk","volume":"183","author":"S Kuhn","year":"2011","journal-title":"CMAJ"},{"key":"pntd.0012264.ref015","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jhin.2023.08.009","article-title":"Virucidal activity of oral, hand, and surface disinfectants against respiratory syncytial virus","volume":"141","author":"TL Meister","year":"2023","journal-title":"J Hosp Infect"},{"key":"pntd.0012264.ref016","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3201\/eid2901.221429","article-title":"Efficient Inactivation of Monkeypox Virus by World Health Organization\u2013Recommended Hand Rub Formulations and Alcohols","volume":"29","author":"TL Meister","year":"2023","journal-title":"Emerg Infect Dis"},{"key":"pntd.0012264.ref017","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1093\/infdis\/jix046","article-title":"Virucidal Activity of World Health Organization-Recommended Formulations Against Enveloped Viruses, Including Zika, Ebola, and Emerging Coronaviruses","volume":"215","author":"A Siddharta","year":"2017","journal-title":"J Infect Dis"},{"key":"pntd.0012264.ref018","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1186\/s12879-015-1111-9","article-title":"Povidone-iodine hand wash and hand rub products demonstrated excellent in vitro virucidal efficacy against Ebola virus and modified vaccinia virus Ankara, the new European test virus for enveloped viruses","volume":"15","author":"M Eggers","year":"2015","journal-title":"BMC Infect Dis"},{"key":"pntd.0012264.ref019","first-page":"269","article-title":"Infant meningoencephalitis caused by yellow fever vaccine virus transmitted via breastmilk","volume":"87","author":"C Traiber","year":"2011","journal-title":"Jornal de pediatria"},{"key":"pntd.0012264.ref020","first-page":"130","article-title":"Transmission of yellow fever vaccine virus through breast-feeding\u2014Brazil, 2009","volume":"59","author":"Centers for Disease Control and Prevention (CDC)","year":"2010","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"pntd.0012264.ref021","unstructured":"Chen LH, Wilson ME. Non-Vector Transmission of Dengue and Other Mosquito-Borne Flaviviruses. Dengue Bulletin. 2005."},{"key":"pntd.0012264.ref022","article-title":"Transmission of arboviruses without involvement of arthropod vectors","author":"G. Kuno","year":"2001","journal-title":"Acta virologica"},{"key":"pntd.0012264.ref023","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1086\/652803","article-title":"How stable is the hepatitis C virus (HCV)? Environmental stability of HCV and its susceptibility to chemical biocides","volume":"201","author":"S Ciesek","year":"2010","journal-title":"J Infect Dis"},{"key":"pntd.0012264.ref024","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/trf.15673","article-title":"Inactivation of yellow fever virus with amotosalen and ultraviolet A light pathogen-reduction technology","volume":"60","author":"YA Girard","year":"2020","journal-title":"Transfusion"},{"key":"pntd.0012264.ref025","unstructured":"World Health Organization. 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WHO guidelines on hand hygiene in health care.; 2009. p. 270."},{"key":"pntd.0012264.ref026","article-title":"Stability and inactivation of monkeypox virus on inanimate surfaces","author":"TL Meister","year":"2023","journal-title":"J Infect Dis"},{"key":"pntd.0012264.ref027","doi-asserted-by":"crossref","first-page":"114264","DOI":"10.1016\/j.jpba.2021.114264","article-title":"Evaluation of hydrogen peroxide virucidal efficacy against yellow fever virus 17DD vaccine strain for application in a vaccine manufacturing industry","volume":"204","author":"AC Ferreira Ballest\u00ea Ajorio","year":"2021","journal-title":"J Pharm Biomed Anal"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0012264","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0012264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T19:36:37Z","timestamp":1719948997000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0012264"}},"subtitle":[],"editor":[{"given":"Abdallah M.","family":"Samy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,6,20]]},"references-count":27,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0012264","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0012264","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,20]]}}}