{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T10:31:47Z","timestamp":1779273107871,"version":"3.51.4"},"update-to":[{"DOI":"10.1371\/journal.pntd.0012272","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:00:00Z","timestamp":1720656000000}}],"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>Histoplasmosis is a frequent cause of infections in people living with HIV\/AIDS (PLWHA). This study introduces the application of a <jats:italic>Histoplasma capsulatum<\/jats:italic> urine antigen lateral flow assay (LFA) for diagnosing disseminated histoplasmosis in PLWHA in Suriname. The LFA\u2019s diagnostic accuracy was compared with the current diagnostic approach, aiming to assess whether this test resulted in improved early detection and management. Additionally, the prevalence of histoplasmosis among advanced stage HIV patients without clinical suspicion of infection was evaluated using the same LFA. In total, 98 patients were included in the study, of which 58 were classified as \u201cpossible disseminated histoplasmosis (DH)\u201d based on clinical criteria and 40 as \u201ccontrols\u201d. Of these possible DH cases, only 19 (32.7%) had a positive LFA. During the study, decisions for treatment were made without the treating physician being aware of the LFA result. Only 55% of the patients who started treatment for histoplasmosis based on clinical criteria had a positive LFA, and 21% of untreated patients had a positive LFA. This study shows that combining clinical signs with LFA results enhances diagnostic accuracy and is cost effective, resulting in better treatment decisions.<\/jats:p>","DOI":"10.1371\/journal.pntd.0012272","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T18:37:26Z","timestamp":1719599846000},"page":"e0012272","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Improving disseminated histoplasmosis diagnosis in HIV\/AIDS patients in Suriname: The role of a urine lateral flow assay"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2970-5556","authenticated-orcid":true,"given":"Lycke","family":"Woittiez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Vestjens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terrence","family":"Mawie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ed","family":"IJzerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter-Jan","family":"Haas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferry","family":"Hagen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimmy","family":"Roosblad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stije","family":"Leopold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maaike D.","family":"van Schagen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mich\u00e8le","family":"van Vugt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Vreden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"issue":"2","key":"pntd.0012272.ref001","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.idc.2021.03.011","article-title":"Histoplasmosis","volume":"35","author":"AB Ara\u00faz","year":"2021","journal-title":"Infect Dis Clin North Am"},{"key":"pntd.0012272.ref002","volume-title":"Open Forum Infectious Diseases","author":"K Benedict","year":"2020"},{"key":"pntd.0012272.ref003","unstructured":"UNAIDS country factsheet Suriname 2022 [Internet]. 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