{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T19:34:57Z","timestamp":1792438497123,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0012315","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000}}],"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82002159"],"award-info":[{"award-number":["82002159"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20200879"],"award-info":[{"award-number":["BK20200879"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["YX13400123"],"award-info":[{"award-number":["YX13400123"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The liver fluke\n                      <jats:italic>Clonorchis sinensis<\/jats:italic>\n                      imports large amounts of glucose to generate energy and metabolic intermediates through glycolysis. We hypothesized that\n                      <jats:italic>C<\/jats:italic>\n                      .\n                      <jats:italic>sinensis<\/jats:italic>\n                      absorbs glucose through glucose transporters and identified four subtypes of glucose transporter (CsGTP) and one sodium glucose co-transporter (CsSGLT) in\n                      <jats:italic>C<\/jats:italic>\n                      .\n                      <jats:italic>sinensis<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methodology\/Principal findings<\/jats:title>\n                    <jats:p>\n                      Expressed sequence tags encoding CsGTPs were retrieved from the\n                      <jats:italic>C<\/jats:italic>\n                      .\n                      <jats:italic>sinensis<\/jats:italic>\n                      transcriptome database, and their full-length cDNA sequences were obtained by rapid amplification of cDNA ends (RACE). The tissue distribution of glucose transporters in\n                      <jats:italic>C<\/jats:italic>\n                      .\n                      <jats:italic>sinensis<\/jats:italic>\n                      adults was determined using immunohistochemical staining. Developmental expression was measured using RT-qPCR. The transport and distribution of glucose into living\n                      <jats:italic>C<\/jats:italic>\n                      .\n                      <jats:italic>sinensis<\/jats:italic>\n                      were monitored using confocal microscopy. Membrane topology and key functional residues of CsGTPs were homologous to their counterparts in animals and humans.\n                      <jats:italic>CsGTP1<\/jats:italic>\n                      ,\n                      <jats:italic>2<\/jats:italic>\n                      , and\n                      <jats:italic>4<\/jats:italic>\n                      were transcribed 2.4\u20135.5 times higher in the adults than metacercariae, while\n                      <jats:italic>CsGTP3<\/jats:italic>\n                      was transcribed 2.1 times higher in the metacercariae than adults.\n                      <jats:italic>CsSGLT<\/jats:italic>\n                      transcription was 163.6 times higher in adults than in metacercariae. In adults, CsSGLT was most abundant in the tegument; CsGTP3 and CsSGLT were localized in the vitelline gland, uterine wall, eggs, mesenchymal tissue, and testes; CsGTP4 was found in sperm and mesenchymal tissue; and CsGTP1 was mainly in the sperm and testes. In\n                      <jats:italic>C<\/jats:italic>\n                      .\n                      <jats:italic>sinensis<\/jats:italic>\n                      adults, exogenous glucose is imported in a short time and is present mainly in the middle and posterior body, in which the somatic and reproductive organs are located. Of the exogenous glucose, 53.6% was imported through CsSGLT and 46.4% through CsGTPs. Exogenous glucose import was effectively inhibited by cytochalasin B and phlorizin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Conclusions\/Significance<\/jats:title>\n                    <jats:p>\n                      We propose that CsSGLT cooperates with CsGTPs to import exogenous glucose from the environmental bile, transport glucose across mesenchymal tissue cells, and finally supply energy-demanding organs in\n                      <jats:italic>C<\/jats:italic>\n                      .\n                      <jats:italic>sinensis<\/jats:italic>\n                      adults. Studies on glucose transporters may pave the way for the development of new anthelmintic drugs.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0012315","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T13:49:03Z","timestamp":1720187343000},"page":"e0012315","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Glucose transporters and sodium glucose co-transporters cooperatively import glucose into energy-demanding organs in carcinogenic liver fluke Clonorchis sinensis"],"prefix":"10.1371","volume":"18","author":[{"given":"Fuhong","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon-Ok","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5331-7560","authenticated-orcid":true,"given":"Jin-Ho","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Gi","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Hee","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelian","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Jong","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"issue":"12","key":"pntd.0012315.ref001","doi-asserted-by":"crossref","first-page":"e1414","DOI":"10.1371\/journal.pntd.0001414","article-title":"Tracing of the bile-chemotactic migration of juvenile Clonorchis sinensis in rabbits by PET-CT.","volume":"5","author":"TI Kim","year":"2011","journal-title":"PLoS Negl Trop Dis."},{"issue":"10","key":"pntd.0012315.ref002","doi-asserted-by":"crossref","first-page":"e0006818","DOI":"10.1371\/journal.pntd.0006818","article-title":"Bile acids drive chemotaxis of Clonorchis sinensis juveniles to the bile duct.","volume":"12","author":"S Li","year":"2018","journal-title":"PLoS Negl Trop Dis"},{"issue":"3","key":"pntd.0012315.ref003","doi-asserted-by":"crossref","first-page":"e0008220","DOI":"10.1371\/journal.pntd.0008220","article-title":"Dopaminergic antagonists inhibit bile chemotaxis of adult Clonorchis sinensis and its egg production.","volume":"14","author":"F Dai","year":"2020","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"pntd.0012315.ref004","first-page":"118","article-title":"Epidemiology of liver cancer: an overview","volume":"5","author":"P Srivatanakul","year":"2004","journal-title":"Asian Pac J Cancer Prev"},{"issue":"3","key":"pntd.0012315.ref005","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3347\/kjp.1969.7.3.143","article-title":"Study on the 14C-glucose metabolism by Clonorchis sinensis: paper chromatographic analyses in combination with autoradiography","volume":"7","author":"IK Kang","year":"1969","journal-title":"Korean J Parasitol"},{"issue":"2","key":"pntd.0012315.ref006","first-page":"59","article-title":"The carbohydrate metabolism of Fasciola hepatica, an example of biochemical adaptations in parasitic helminths.","volume":"45","author":"AGM Tielens","year":"2000","journal-title":"Acta Parasitol."},{"issue":"5","key":"pntd.0012315.ref007","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1085\/jgp.33.5.475","article-title":"Carbohydrate metabolism of Schistosoma mansoni","volume":"33","author":"E. Bueding","year":"1950","journal-title":"J Gen Physiol"},{"key":"pntd.0012315.ref008","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1042\/bj3250569","article-title":"Kinetoplastid glucose transporters","volume":"325","author":"E Tetaud","year":"1997","journal-title":"Biochem J"},{"issue":"3","key":"pntd.0012315.ref009","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.bcp.2003.09.005","article-title":"Interaction of substituted hexose analogues with the Trypanosoma brucei hexose transporter","volume":"67","author":"L Azema","year":"2004","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"pntd.0012315.ref010","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0166-6851(97)00192-8","article-title":"Trypanosome glucose transporters","volume":"91","author":"MP Barrett","year":"1998","journal-title":"Mol Biochem Parasitol"},{"issue":"6","key":"pntd.0012315.ref011","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1111\/j.1365-2958.2010.07060.x","article-title":"Life cycle studies of the hexose transporter of Plasmodium species and genetic validation of their essentiality","volume":"75","author":"K Slavic","year":"2010","journal-title":"Mol Microbiol"},{"key":"pntd.0012315.ref012","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1017\/S003118209800345X","article-title":"Molecular and functional characterization and tissue localization of 2 glucose transporter homologues (TGTP1 and TGTP2) from the tapeworm Taenia solium.","volume":"117","author":"D Rodriguez-Contreras","year":"1998","journal-title":"Parasitology"},{"issue":"6","key":"pntd.0012315.ref013","doi-asserted-by":"crossref","first-page":"4247","DOI":"10.1016\/S0021-9258(17)41770-4","article-title":"Cloning, characterization, and functional expression of cDNAs encoding glucose transporter proteins from the human parasite Schistosoma mansoni","volume":"269","author":"PJ Skelly","year":"1994","journal-title":"J Biol Chem"},{"issue":"8","key":"pntd.0012315.ref014","doi-asserted-by":"crossref","first-page":"3642","DOI":"10.1073\/pnas.93.8.3642","article-title":"Rapid appearance and asymmetric distribution of glucose transporter SGTP4 at the apical surface of intramammalian-stage Schistosoma mansoni","volume":"93","author":"PJ Skelly","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"pntd.0012315.ref015","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1006\/expr.1996.0025","article-title":"Schistosoma mansoni: the glucose transport protein SGTP4 is present in tegumental multilamellar bodies, discoid bodies, and the surface lipid bilayers","volume":"82","author":"J Jiang","year":"1996","journal-title":"Exp Parasitol"},{"issue":"6","key":"pntd.0012315.ref016","doi-asserted-by":"crossref","first-page":"e1000932","DOI":"10.1371\/journal.ppat.1000932","article-title":"Suppressing glucose transporter gene expression in schistosomes impairs parasite feeding and decreases survival in the mammalian host","volume":"6","author":"G Krautz-Peterson","year":"2010","journal-title":"PLoS Pathog"},{"issue":"1","key":"pntd.0012315.ref017","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.molbiopara.2008.07.005","article-title":"An expression system to screen for inhibitors of parasite glucose transporters","volume":"162","author":"T Feistel","year":"2008","journal-title":"Mol Biochem Parasitol"},{"key":"pntd.0012315.ref018","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1186\/1756-0500-7-388","article-title":"ClonorESTdb: a comprehensive database for Clonorchis sinensis EST sequences.","volume":"7","author":"DW Kim","year":"2014","journal-title":"BMC Res Notes"},{"issue":"4","key":"pntd.0012315.ref019","doi-asserted-by":"crossref","first-page":"e0006459","DOI":"10.1371\/journal.pntd.0006459","article-title":"Characterization of a novel organic solute transporter homologue from Clonorchis sinensis.","volume":"12","author":"Y Lu","year":"2018","journal-title":"PLoS Negl Trop Dis"},{"issue":"3","key":"pntd.0012315.ref020","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1006\/jmbi.2000.4315","article-title":"Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes","volume":"305","author":"A Krogh","year":"2001","journal-title":"J Mol Biol"},{"issue":"12","key":"pntd.0012315.ref021","doi-asserted-by":"crossref","first-page":"e0008952","DOI":"10.1371\/journal.pntd.0008952","article-title":"Sodium-bile acid co-transporter is crucial for survival of a carcinogenic liver fluke Clonorchis sinensis in the bile","volume":"14","author":"F Dai","year":"2020","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"pntd.0012315.ref022","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0166-6851(00)00220-6","article-title":"Molecular cloning and immunological characterization of phosphoglycerate kinase from Clonorchis sinensis","volume":"108","author":"SJ Hong","year":"2000","journal-title":"Mol Biochem Parasitol"},{"issue":"4","key":"pntd.0012315.ref023","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT method.","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"issue":"42","key":"pntd.0012315.ref024","doi-asserted-by":"crossref","first-page":"12897","DOI":"10.1021\/bi971173c","article-title":"Role of conserved arginine and glutamate residues on the cytosolic surface of glucose transporters for transporter function","volume":"36","author":"A Schurmann","year":"1997","journal-title":"Biochemistry"},{"issue":"4","key":"pntd.0012315.ref025","doi-asserted-by":"crossref","first-page":"e0125361","DOI":"10.1371\/journal.pone.0125361","article-title":"Molecular dynamics simulations of the human glucose transporter GLUT1.","volume":"10","author":"MS Park","year":"2015","journal-title":"PloS one"},{"issue":"10","key":"pntd.0012315.ref026","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1021\/bi992160x","article-title":"Cysteine scanning mutagenesis of helices 2 and 7 in GLUT1 identifies an exofacial cleft in both transmembrane segments","volume":"39","author":"A Olsowski","year":"2000","journal-title":"Biochemistry"},{"issue":"32","key":"pntd.0012315.ref027","doi-asserted-by":"crossref","first-page":"20533","DOI":"10.1016\/S0021-9258(17)32026-4","article-title":"Glutamine 161 of Glut1 glucose transporter is critical for transport activity and exofacial ligand binding","volume":"269","author":"M Mueckler","year":"1994","journal-title":"J Biol Chem"},{"key":"pntd.0012315.ref028","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1042\/bj3020355","article-title":"Replacement of both tryptophan residues at 388 and 412 completely abolished cytochalasin B photolabelling of the GLUT1 glucose transporter","volume":"302","author":"K Inukai","year":"1994","journal-title":"Biochem J"},{"issue":"2","key":"pntd.0012315.ref029","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/0014-5793(94)00558-3","article-title":"Substitution of conserved tyrosine residues in helix 4 (Y143) and 7 (Y293) affects the activity, but not IAPS-forskolin binding, of the glucose transporter GLUT4.","volume":"348","author":"S Wandel","year":"1994","journal-title":"FEBS Lett"},{"issue":"15","key":"pntd.0012315.ref030","doi-asserted-by":"crossref","first-page":"11578","DOI":"10.1016\/S0021-9258(19)78163-0","article-title":"Substitution of tyrosine 293 of GLUT1 locks the transporter into an outward facing conformation","volume":"269","author":"H Mori","year":"1994","journal-title":"J Biol Chem"},{"issue":"31","key":"pntd.0012315.ref031","doi-asserted-by":"crossref","first-page":"9367","DOI":"10.1021\/bi000821g","article-title":"Cysteine-scanning mutagenesis of transmembrane segment 11 of the GLUT1 facilitative glucose transporter","volume":"39","author":"PW Hruz","year":"2000","journal-title":"Biochemistry"},{"key":"pntd.0012315.ref032","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1186\/s12864-015-2144-6","article-title":"Fast evolutionary rates associated with functional loss in class I glucose transporters of Schistosoma mansoni","volume":"16","author":"A Cabezas-Cruz","year":"2015","journal-title":"BMC genomics"},{"issue":"2","key":"pntd.0012315.ref033","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1152\/physrev.00055.2009","article-title":"Biology of human sodium glucose transporters","volume":"91","author":"EM Wright","year":"2011","journal-title":"Physiol Rev"},{"key":"pntd.0012315.ref034","first-page":"370","article-title":"Surprising versatility of Na+-glucose cotransporters: SLC5.","volume":"19","author":"EM Wright","year":"2004","journal-title":"Physiology (Bethesda)."},{"issue":"5","key":"pntd.0012315.ref035","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s00424-003-1202-0","article-title":"The sodium\/glucose cotransport family SLC5","volume":"447","author":"EM Wright","year":"2004","journal-title":"Pflugers Arch"},{"issue":"47","key":"pntd.0012315.ref036","doi-asserted-by":"crossref","first-page":"13616","DOI":"10.1021\/bi701193x","article-title":"D-Glucose-recognition and phlorizin-binding sites in human sodium\/D-glucose cotransporter 1 (hSGLT1): a tryptophan scanning study.","volume":"46","author":"NK Tyagi","year":"2007","journal-title":"Biochemistry"},{"issue":"10","key":"pntd.0012315.ref037","doi-asserted-by":"crossref","first-page":"7975","DOI":"10.1074\/jbc.M110.187880","article-title":"Sugar binding residue affects apparent Na+ affinity and transport stoichiometry in mouse sodium\/glucose cotransporter type 3B","volume":"286","author":"A Diez-Sampedro","year":"2011","journal-title":"J Biol Chem"},{"issue":"47","key":"pntd.0012315.ref038","first-page":"E4557","article-title":"Functional identification and characterization of sodium binding sites in Na symporters","volume":"110","author":"DD Loo","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"pntd.0012315.ref039","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.molbiopara.2008.11.008","article-title":"Acetate:succinate CoA-transferase in the anaerobic mitochondria of Fasciola hepatica","volume":"164","author":"KW van Grinsven","year":"2009","journal-title":"Mol Biochem Parasitol"},{"issue":"3","key":"pntd.0012315.ref040","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.exppara.2006.03.007","article-title":"Schistosoma mansoni: biochemical characterization of lactate transporters or similar proteins","volume":"114","author":"EK Githui","year":"2006","journal-title":"Exp Parasitol"},{"issue":"4","key":"pntd.0012315.ref041","first-page":"281","article-title":"The uptake of C14 glucose by Clonorchis sinensis.","volume":"4","author":"SJ Hahn","year":"1961","journal-title":"Kor J Int Med"},{"issue":"6","key":"pntd.0012315.ref042","doi-asserted-by":"crossref","first-page":"e1208","DOI":"10.1371\/journal.pntd.0001208","article-title":"Developmental transcriptomic features of the carcinogenic liver fluke, Clonorchis sinensis.","volume":"5","author":"WG Yoo","year":"2011","journal-title":"PLoS Negl Trop Dis."},{"issue":"2","key":"pntd.0012315.ref043","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1172\/JCI107586","article-title":"Glucose reabsorption from bile. Evidence for a biliohepatic circulation","volume":"53","author":"P Guzelian","year":"1974","journal-title":"J Clin Invest"},{"issue":"3","key":"pntd.0012315.ref044","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1645\/0022-3395(2001)087[0510:HCCIOA]2.0.CO;2","article-title":"Human cerebral cysticercosis: immunolocalization of a sodium-dependent glucose cotransporter (SGLT) in larval and adult tapeworms.","volume":"87","author":"EM Cornford","year":"2001","journal-title":"J Parasitol"},{"key":"pntd.0012315.ref045","first-page":"176","author":"AF Hofmann","year":"2003","journal-title":"Encyclopedia of Gastroenterology: Academic Press"},{"issue":"1","key":"pntd.0012315.ref046","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3923\/pjbs.2008.113.117","article-title":"The study of vitelline gland of Haploporus lateralis (Digenea: Trematoda).","volume":"11","author":"M. Sampour","year":"2008","journal-title":"Pak J Biol Sci"},{"issue":"6","key":"pntd.0012315.ref047","doi-asserted-by":"crossref","first-page":"932","DOI":"10.4269\/ajtmh.1999.60.932","article-title":"Resistance to praziquantel: direct evidence from Schistosoma mansoni isolated from Egyptian villagers","volume":"60","author":"M Ismail","year":"1999","journal-title":"Am J Trop Med Hyg"},{"issue":"3","key":"pntd.0012315.ref048","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S1471-4922(01)02209-7","article-title":"Interpreting low praziquantel cure rates of Schistosoma mansoni infections in Senegal","volume":"18","author":"A Danso-Appiah","year":"2002","journal-title":"Trends Parasitol"},{"issue":"8","key":"pntd.0012315.ref049","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.ijpara.2004.04.005","article-title":"Validation of sensitivity to praziquantel using Schistosoma mansoni worm muscle tension and Ca2+-uptake as possible in vitro correlates to in vivo ED50 determination","volume":"34","author":"S William","year":"2004","journal-title":"Int J Parasitol"},{"issue":"7","key":"pntd.0012315.ref050","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.ijpara.2005.02.005","article-title":"Current status of sensitivity to praziquantel in a focus of potential drug resistance in Egypt","volume":"35","author":"S Botros","year":"2005","journal-title":"Int J Parasitol"},{"issue":"3\u20134","key":"pntd.0012315.ref051","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0304-4157(76)90003-4","article-title":"Glucose transport in the kidney","volume":"457","author":"M. Silverman","year":"1976","journal-title":"Biochim Biophys Acta"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0012315","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0012315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T13:38:27Z","timestamp":1721223507000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0012315"}},"subtitle":[],"editor":[{"given":"Gabriel","family":"Rinaldi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,7,5]]},"references-count":51,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0012315","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,5]]}}}