{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:24:42Z","timestamp":1787502282118,"version":"build-2736575974"},"update-to":[{"DOI":"10.1371\/journal.pntd.0012474","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000}}],"reference-count":65,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH NIAID","award":["R01AI143991"],"award-info":[{"award-number":["R01AI143991"]}]},{"name":"NIH","award":["1R01AI133749"],"award-info":[{"award-number":["1R01AI133749"]}]},{"name":"NIH","award":["R21 AI096277"],"award-info":[{"award-number":["R21 AI096277"]}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>\n                    The trematodes that cause schistosomiasis in humans require aquatic snails as intermediate hosts. Identifying the genes in snails at which allelic variation controls resistance to infection by schistosomes could lead to novel ways to break the cycle of transmission. We therefore mapped genetic variation within the BS90 population of\n                    <jats:italic>Biomphalaria glabrata<\/jats:italic>\n                    snails that controls their resistance to infection by the SmLE population of\n                    <jats:italic>Schistosoma mansoni<\/jats:italic>\n                    . A marker in the\n                    <jats:italic>PTC2<\/jats:italic>\n                    genomic region strongly associates with variation in resistance. The\n                    <jats:italic>S<\/jats:italic>\n                    -haplotype, which confers increased susceptibility, appears to be almost completely dominant to the\n                    <jats:italic>R<\/jats:italic>\n                    -haplotype, which confers increased resistance. This result suggests a model in which the parasite must match a molecule on the host side to successfully infect. The genomic region surrounding our marker shows high structural and sequence variability between haplotypes. It is also highly enriched for genes that code for single-pass transmembrane (TM1) genes. Several of the TM1 genes present on the\n                    <jats:italic>S<\/jats:italic>\n                    -haplotype lack orthologs on the\n                    <jats:italic>R<\/jats:italic>\n                    -haplotype, which makes them intriguing candidate genes in a model of dominant susceptibility. These results add to a growing body of work that suggests TM1 genes, especially those in this exceptionally diverse genomic region, may play an important role in snail-schistosome compatibility polymorphisms.\n                  <\/jats:p>","DOI":"10.1371\/journal.pntd.0012474","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T14:02:45Z","timestamp":1726495365000},"page":"e0012474","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Susceptibility of BS90 Biomphalaria glabrata snails to infection by SmLE Schistosoma mansoni segregates as a dominant allele in a cluster of polymorphic genes for single-pass transmembrane proteins"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8439-2878","authenticated-orcid":true,"given":"Michael S.","family":"Blouin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie R.","family":"Bollmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winka","family":"Le Clec\u2019h","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric D.","family":"Chevalier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J. C.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob A.","family":"Tennessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"key":"pntd.0012474.ref001","unstructured":"WHO. WHO guideline on control and elimination of human schistosomiasis [Internet]. 2022 [cited 2022 Dec 22]. https:\/\/www.who.int\/publications\/i\/item\/9789240041608"},{"issue":"2","key":"pntd.0012474.ref002","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.actatropica.2009.11.012","article-title":"Parasites and poverty: The case of schistosomiasis","volume":"113","author":"CH King","year":"2010","journal-title":"Acta Tropica"},{"issue":"7","key":"pntd.0012474.ref003","doi-asserted-by":"crossref","first-page":"e0004794","DOI":"10.1371\/journal.pntd.0004794","article-title":"Global Assessment of Schistosomiasis Control Over the Past Century Shows Targeting the Snail Intermediate Host Works Best","volume":"10","author":"SH Sokolow","year":"2016","journal-title":"PLoS Neglected Tropical Diseases"},{"issue":"4","key":"pntd.0012474.ref004","doi-asserted-by":"crossref","first-page":"e0003657","DOI":"10.1371\/journal.pntd.0003657","article-title":"Historical Perspective: Snail Control to Prevent Schistosomiasis","volume":"9","author":"CH King","year":"2015","journal-title":"PLoS Neglected Tropical Diseases"},{"issue":"5","key":"pntd.0012474.ref005","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1179\/2047773214Y.0000000149","article-title":"Water-based interventions for schistosomiasis control","volume":"108","author":"WE Secor","year":"2014","journal-title":"Pathogens and Global Health"},{"issue":"2","key":"pntd.0012474.ref006","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1139\/z03-215","article-title":"Trematodes and snails: an intimate association","volume":"82","author":"AE Lockyer","year":"2004","journal-title":"Can J Zool"},{"issue":"6","key":"pntd.0012474.ref007","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.2307\/3282295","article-title":"The Genetic Variation of Compatibility in Biomphalaria glabrata and Schistosoma mansoni","volume":"73","author":"CS Richards","year":"1987","journal-title":"The Journal of Parasitology"},{"issue":"6","key":"pntd.0012474.ref008","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.2307\/2411336","article-title":"Selection and strain specificity of compatibility between snail intermediate hosts and their parasitic schistosomes","volume":"52","author":"MEJ Webster JP Woolhouse","year":"1998","journal-title":"Evolution Int J Org Evolution"},{"issue":"Suppl 5","key":"pntd.0012474.ref009","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1086\/424607","article-title":"Do hosts and parasites coevolve? Empirical support from the Schistosoma system","volume":"164","author":"JP Webster","year":"2004","journal-title":"Am Nat"},{"key":"pntd.0012474.ref010","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.meegid.2014.04.025","article-title":"Multi-parasite host susceptibility and multi-host parasite infectivity: A new approach of the Biomphalaria glabrata\/Schistosoma mansoni compatibility polymorphism","volume":"26","author":"A Theron","year":"2014","journal-title":"Infection, Genetics and Evolution"},{"issue":"6","key":"pntd.0012474.ref011","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2307\/3273632","article-title":"A Study on the Comparative Susceptibility of Snail Vectors to Strains of Schistosoma mansoni","volume":"35","author":"VS Files","year":"1949","journal-title":"The Journal of Parasitology"},{"issue":"6","key":"pntd.0012474.ref012","doi-asserted-by":"crossref","first-page":"e99573","DOI":"10.1371\/journal.pone.0099573","article-title":"Reduced Susceptibility of a Biomphalaria tenagophila Population to Schistosoma mansoni after Introducing the Resistant Taim\/RS Strain of B. tenagophila into Herivelton Martins Stream","volume":"9","author":"A Marques DP de","year":"2014","journal-title":"PLOS ONE"},{"issue":"3","key":"pntd.0012474.ref013","article-title":"Treading the Path towards Genetic Control of Snail Resistance to Schistosome Infection","volume":"3","author":"DO Famakinde","year":"2018","journal-title":"Trop Med Infect Dis"},{"issue":"12","key":"pntd.0012474.ref014","doi-asserted-by":"crossref","first-page":"e0007833","DOI":"10.1371\/journal.pntd.0007833","article-title":"Gene drives for schistosomiasis transmission control","volume":"13","author":"T Maier","year":"2019","journal-title":"PLoS Negl Trop Dis"},{"issue":"10","key":"pntd.0012474.ref015","doi-asserted-by":"crossref","first-page":"e0010894","DOI":"10.1371\/journal.pntd.0010894","article-title":"Modeling the efficacy of CRISPR gene drive for snail immunity on schistosomiasis control","volume":"16","author":"RE Grewelle","year":"2022","journal-title":"PLOS Neglected Tropical Diseases"},{"key":"pntd.0012474.ref016","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/bs.apar.2016.08.006","article-title":"The Compatibility Between Biomphalaria glabrata Snails and Schistosoma mansoni: An Increasingly Complex Puzzle","volume":"97","author":"G Mitta","year":"2017","journal-title":"Adv Parasitol"},{"issue":"11","key":"pntd.0012474.ref017","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.pt.2017.07.006","article-title":"Schistosomiasis from a Snail\u2019s Perspective: Advances in Snail Immunity","volume":"33","author":"EA Pila","year":"2017","journal-title":"Trends Parasitol"},{"key":"pntd.0012474.ref018","first-page":"103557","article-title":"Biomphalaria glabrata immunity: Post-genome advances","author":"MG Castillo","year":"2019","journal-title":"Developmental & Comparative Immunology"},{"key":"pntd.0012474.ref019","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.3389\/fimmu.2020.624178","article-title":"Immune Evasion Strategies of Schistosomes","volume":"11","author":"JR Hambrook","year":"2021","journal-title":"Frontiers in Immunology"},{"issue":"4","key":"pntd.0012474.ref020","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1073\/pnas.96.4.1510","article-title":"The identification of markers segregating with resistance to Schistosoma mansoni infection in the snail Biomphalaria glabrata","volume":"96","author":"M Knight","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"pntd.0012474.ref021","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.molbiopara.2006.02.009","article-title":"Biomphalaria glabrata cytosolic copper\/zinc superoxide dismutase (SOD1) gene: Association of SOD1 alleles with resistance\/susceptibility to Schistosoma mansoni","volume":"147","author":"CP Goodall","year":"2006","journal-title":"Molecular and Biochemical Parasitology"},{"issue":"3","key":"pntd.0012474.ref022","doi-asserted-by":"crossref","first-page":"e1005067","DOI":"10.1371\/journal.pgen.1005067","article-title":"Hyperdiverse gene cluster in snail host conveys resistance to human schistosome parasites","volume":"11","author":"JA Tennessen","year":"2015","journal-title":"PLoS Genet"},{"issue":"9","key":"pntd.0012474.ref023","doi-asserted-by":"crossref","first-page":"e0004077","DOI":"10.1371\/journal.pntd.0004077","article-title":"Genome-Wide Scan and Test of Candidate Genes in the Snail Biomphalaria glabrata Reveal New Locus Influencing Resistance to Schistosoma mansoni","volume":"9","author":"JA Tennessen","year":"2015","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"pntd.0012474.ref024","doi-asserted-by":"crossref","first-page":"e59395","DOI":"10.7554\/eLife.59395","article-title":"Clusters of polymorphic transmembrane genes control resistance to schistosomes in snail vectors","volume":"9","author":"JA Tennessen","year":"2020","journal-title":"eLife"},{"issue":"2","key":"pntd.0012474.ref025","article-title":"Schistosome infectivity in the snail, Biomphalaria glabrata, is partially dependent on the expression of Grctm6, a Guadeloupe Resistance Complex protein","volume":"11","author":"ERO Allan","year":"2017","journal-title":"Plos Neglect Trop D"},{"key":"pntd.0012474.ref026","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.fsi.2017.10.037","article-title":"Allelic variation partially regulates galactose-dependent hydrogen peroxide release from circulating hemocytes of the snail Biomphalaria glabrata","volume":"72","author":"ERO Allan","year":"2018","journal-title":"Fish Shellfish Immunol"},{"issue":"5","key":"pntd.0012474.ref027","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ijpara.2017.08.008","article-title":"Clearance of schistosome parasites by resistant genotypes at a single genomic region in Biomphalaria glabrata snails involves cellular components of the hemolymph","volume":"48","author":"ERO Allan","year":"2018","journal-title":"Int J Parasitol"},{"issue":"9","key":"pntd.0012474.ref028","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.dci.2006.12.005","article-title":"Variation in expression of Biomphalaria glabrata SOD1: A potential controlling factor in susceptibility\/resistance to Schistosoma mansoni","volume":"31","author":"RC Bender","year":"2007","journal-title":"Developmental and Comparative Immunology"},{"key":"pntd.0012474.ref029","first-page":"15","article-title":"Variation in susceptibility of populations of Australorbis glabratus to a strain of Schistosoma mansoni","volume":"5","author":"WL Paraense","year":"1963","journal-title":"Rev Inst Med Trop Sao Paulo"},{"issue":"10","key":"pntd.0012474.ref030","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.dci.2008.03.001","article-title":"Fibrinogen-bearing protein genes in the snail Biomphalaria glabrata: characterization of two novel genes and expression studies during ontogenesis and trematode infection","volume":"32","author":"SM Zhang","year":"2008","journal-title":"Dev Comp Immunol"},{"issue":"3","key":"pntd.0012474.ref031","doi-asserted-by":"crossref","first-page":"e1569","DOI":"10.1371\/journal.pntd.0001569","article-title":"Glycotope sharing between snail hemolymph and larval schistosomes: larval transformation products alter shared glycan patterns of plasma proteins","volume":"6","author":"TP Yoshino","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"issue":"4","key":"pntd.0012474.ref032","doi-asserted-by":"crossref","first-page":"e1002677","DOI":"10.1371\/journal.ppat.1002677","article-title":"Reversing the Resistance Phenotype of the Biomphalaria glabrata Snail Host Schistosoma mansoni Infection by Temperature Modulation","volume":"8","author":"W Ittiprasert","year":"2012","journal-title":"PLoS Pathog"},{"issue":"3","key":"pntd.0012474.ref033","doi-asserted-by":"crossref","first-page":"e1005513","DOI":"10.1371\/journal.ppat.1005513","article-title":"A Novel Toll-Like Receptor (TLR) Influences Compatibility between the Gastropod Biomphalaria glabrata, and the Digenean Trematode Schistosoma mansoni","volume":"12","author":"EA Pila","year":"2016","journal-title":"PLOS Pathogens"},{"issue":"19","key":"pntd.0012474.ref034","doi-asserted-by":"crossref","first-page":"5305","DOI":"10.1073\/pnas.1521239113","article-title":"Endogenous growth factor stimulation of hemocyte proliferation induces resistance to Schistosoma mansoni challenge in the snail host","volume":"113","author":"EA Pila","year":"2016","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"1","key":"pntd.0012474.ref035","first-page":"1","article-title":"Compatibility between snails and schistosomes: insights from new genetic resources, comparative genomics, and genetic mapping","volume":"5","author":"L Bu","year":"2022","journal-title":"Commun Biol"},{"issue":"10","key":"pntd.0012474.ref036","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1017\/S0031182008004745","article-title":"Effects of laboratory culture on compatibility between snails and schistosomes","volume":"135","author":"A Theron","year":"2008","journal-title":"Parasitology"},{"key":"pntd.0012474.ref037","unstructured":"Ulmer MJ. Laboratory Maintenance of Parasites. In: Experiments and Techniques in Parasitology MacInnis and M Voge (eds). W.H. Freeman and Company; 1970. p. 143\u20134."},{"issue":"11","key":"pntd.0012474.ref038","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nrg3803","article-title":"Sequencing pools of individuals\u2014mining genome-wide polymorphism data without big funding","volume":"15","author":"C Schl\u00f6tterer","year":"2014","journal-title":"Nat Rev Genet"},{"issue":"12","key":"pntd.0012474.ref039","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0168-9525(93)90102-N","article-title":"Extraction of high molecular weight DNA from molluscs","volume":"9","author":"B Winnepenninckx","year":"1993","journal-title":"Trends Genet"},{"key":"pntd.0012474.ref040","doi-asserted-by":"crossref","first-page":"e13971","DOI":"10.7717\/peerj.13971","article-title":"PTC2 region genotypes counteract Biomphalaria glabrata population differences between M-line and BS90 in resistance to infection by Schistosoma mansoni","volume":"10","author":"MS Blouin","year":"2022","journal-title":"PeerJ"},{"issue":"7253","key":"pntd.0012474.ref041","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature08160","article-title":"The genome of the blood fluke Schistosoma mansoni","volume":"460","author":"M Berriman","year":"2009","journal-title":"Nature"},{"issue":"1","key":"pntd.0012474.ref042","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"M. Martin","year":"2011","journal-title":"EMBnet.journal"},{"issue":"15","key":"pntd.0012474.ref043","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"AM Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"pntd.0012474.ref044","unstructured":"Li H. Aligning sequence reads, clone sequences and assembly contigs with BWA-MEM [Internet]. arXiv; 2013 [cited 2024 Apr 24]. http:\/\/arxiv.org\/abs\/1303.3997"},{"issue":"16","key":"pntd.0012474.ref045","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The Sequence Alignment\/Map format and SAMtools","volume":"25","author":"H Li","year":"2009","journal-title":"Bioinformatics"},{"issue":"12","key":"pntd.0012474.ref046","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/nmeth.4035","article-title":"Phased diploid genome assembly with single-molecule real-time sequencing","volume":"13","author":"CS Chin","year":"2016","journal-title":"Nat Methods"},{"issue":"6","key":"pntd.0012474.ref047","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nmeth.2474","article-title":"Nonhybrid, finished microbial genome assemblies from long-read SMRT sequencing data","volume":"10","author":"CS Chin","year":"2013","journal-title":"Nat Methods"},{"issue":"5","key":"pntd.0012474.ref048","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/s41587-019-0072-8","article-title":"Assembly of long, error-prone reads using repeat graphs","volume":"37","author":"M Kolmogorov","year":"2019","journal-title":"Nat Biotechnol"},{"issue":"52","key":"pntd.0012474.ref049","first-page":"E8396","article-title":"Assembly of long error-prone reads using de Bruijn graphs","volume":"113","author":"Y Lin","year":"2016","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"pntd.0012474.ref050","doi-asserted-by":"crossref","first-page":"e4958","DOI":"10.7717\/peerj.4958","article-title":"D-GENIES: dot plot large genomes in an interactive, efficient and simple way","volume":"6","author":"F Cabanettes","year":"2018","journal-title":"PeerJ"},{"key":"pntd.0012474.ref051","first-page":"175","article-title":"A hidden Markov model for predicting transmembrane helices in protein sequences","volume":"6","author":"EL Sonnhammer","year":"1998","journal-title":"Proc Int Conf Intell Syst Mol Biol"},{"issue":"2","key":"pntd.0012474.ref052","doi-asserted-by":"crossref","first-page":"e1006596","DOI":"10.1371\/journal.pgen.1006596","article-title":"The genetic basis of resistance and matching-allele interactions of a host-parasite system: The Daphnia magna-Pasteuria ramosa model","volume":"13","author":"G Bento","year":"2017","journal-title":"PLOS Genetics"},{"issue":"1","key":"pntd.0012474.ref053","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s12864-024-10103-w","article-title":"The genome and transcriptome of the snail Biomphalaria sudanica s.l.: immune gene diversification and highly polymorphic genomic regions in an important African vector of Schistosoma mansoni","volume":"25","author":"T Pennance","year":"2024","journal-title":"BMC Genomics"},{"issue":"6","key":"pntd.0012474.ref054","doi-asserted-by":"crossref","first-page":"E230","DOI":"10.1086\/645087","article-title":"Inverse-Gene-for-Gene Infection Genetics and Coevolutionary Dynamics","volume":"174","author":"A Fenton","year":"2009","journal-title":"The American Naturalist"},{"issue":"6593","key":"pntd.0012474.ref055","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/382722a0","article-title":"Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene","volume":"382","author":"M Samson","year":"1996","journal-title":"Nature"},{"issue":"1","key":"pntd.0012474.ref056","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.exppara.2012.10.002","article-title":"Circulating Biomphalaria glabrata hemocyte subpopulations possess shared schistosome glycans and receptors capable of binding larval glycoconjugates","volume":"133","author":"TP Yoshino","year":"2013","journal-title":"Experimental Parasitology"},{"issue":"5","key":"pntd.0012474.ref057","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0169-4758(92)90015-T","article-title":"Genetics of Biomphalaria glabrata and its effect on the outcome of Schistosoma mansoni infection","volume":"8","author":"CS Richards","year":"1992","journal-title":"Parasitol Today"},{"issue":"6","key":"pntd.0012474.ref058","first-page":"1178","article-title":"Fitness of Indirectly Transmitted Pathogens: Restraint and Constraint","volume":"58","author":"CM Gower","year":"2004","journal-title":"Evolution"},{"issue":"6","key":"pntd.0012474.ref059","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.2307\/2411336","article-title":"Selection and Strain Specificity of Compatibility Between Snail Intermediate Hosts and Their Parasitic Schistosomes","volume":"52","author":"JP Webster","year":"1998","journal-title":"Evolution"},{"key":"pntd.0012474.ref060","unstructured":"Chevalier FD, Le Clec\u2019h W, LoVerde PT, Gourbal B, Mitta G, Anderson TJC. Bulk segregant analysis of host specificity in schistosome parasites. In: Proceedings of the 2021 Meetings of the British Society of Parasitology; 2021 June 21\u201325; Online Meetings. 2021. Abstract A23519. https:\/\/bsp.uk.net\/media\/BSP-Parasites-Online-2021.pdf, https:\/\/bsp.uk.net\/Abstracts-from-past-meetings."},{"issue":"12","key":"pntd.0012474.ref061","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.cub.2013.04.064","article-title":"A Matching-Allele Model Explains Host Resistance to Parasites","volume":"23","author":"P Luijckx","year":"2013","journal-title":"Current Biology"},{"key":"pntd.0012474.ref062","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.3389\/fpls.2015.01084","article-title":"Epidemiological and Evolutionary Outcomes in Gene-for-Gene and Matching Allele Models","volume":"6","author":"PH Thrall","year":"2016","journal-title":"Front Plant Sci"},{"issue":"31","key":"pntd.0012474.ref063","doi-asserted-by":"crossref","first-page":"9650","DOI":"10.1073\/pnas.1502651112","article-title":"Reduced transmission of human schistosomiasis after restoration of a native river prawn that preys on the snail intermediate host","volume":"112","author":"SH Sokolow","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pntd.0012474.ref064","article-title":"Impact and cost-effectiveness of snail control to achieve disease control targets for schistosomiasis","author":"NC Lo","year":"2018","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"pntd.0012474.ref065","doi-asserted-by":"crossref","unstructured":"Grewelle RE, Perez-Saez J, Tycko J, Namigai EKO, Rickards CG, Leo GAD. Modeling the efficacy of CRISPR gene drive for schistosomiasis control [Internet]. 2021 Oct [cited 2021 Nov 7] p. 2021.10.29.466423. https:\/\/www.biorxiv.org\/content\/10.1101\/2021.10.29.466423v1","DOI":"10.1101\/2021.10.29.466423"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0012474","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0012474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T13:51:11Z","timestamp":1727358671000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0012474"}},"subtitle":[],"editor":[{"given":"Ronaldo de Carvalho","family":"Augusto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,9,16]]},"references-count":65,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,9,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0012474","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,16]]}}}