{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T07:32:42Z","timestamp":1782545562791,"version":"3.54.5"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30960331"],"award-info":[{"award-number":["30960331"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81660554"],"award-info":[{"award-number":["81660554"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Support Plan for Talents in Yunnan under Grant","award":["YNWR-MY-2018-035"],"award-info":[{"award-number":["YNWR-MY-2018-035"]}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515011854"],"award-info":[{"award-number":["2022A1515011854"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shenzhen Science and Technology Program","award":["KQTD20200820145822023"],"award-info":[{"award-number":["KQTD20200820145822023"]}]},{"name":"Guangdong Province \u201cPearl River Talent Plan\u201d Innovation and Entrepreneurship Team Project","award":["2019ZT08Y464"],"award-info":[{"award-number":["2019ZT08Y464"]}]},{"name":"Yunnan Reserve Talents for Academic and Technical Leaders of Middle-Aged and Young People","award":["2019HB052"],"award-info":[{"award-number":["2019HB052"]}]},{"name":"Yunnan Revitalization Talent Support Program Top Physician Project","award":["XDYC-MY-2022-0074"],"award-info":[{"award-number":["XDYC-MY-2022-0074"]}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>Seoul orthohantavirus (SEOV) has been identified as one of the main causative agents of hemorrhagic fever with renal syndrome (HFRS) in China. The virus was found circulating in rodent populations in almost all provinces of the country, reflecting the wide distribution of HFRS. Here, using the direct immunofluorescence assay (DFA) and real-time quantitative reverse transcription PCR (qRT-PCR) approach, we performed screening in 1784 small mammals belonging to 14 species of three orders captured in the main areas of HFRS endemicity in Yunnan province (southwestern China) and identified 37 SEOV-positive rats (36 <jats:italic>Rattus norvegicus<\/jats:italic> and 1 <jats:italic>Rattus tanezumi<\/jats:italic>). A 3-year surveillance of HFRS epidemics and dynamics of rodent reservoir density and virus prevalence implied a potential correlation between them. The subsequent meta-transcriptomic sequencing and phylogenetic analyses revealed three SEOV variants, among which two are completely novel. The ancestral character state reconstruction (ACSR) analysis based on both novel variants and documented strains from 5 continents demonstrated that SEOV appeared to originate near the southwestern area (Yunnan-Kweichow Plateau) of China, then could spread to other regions and countries by their rodent carriers, resulting in a global distribution today. In summary, these data furthered the understanding regards genetic diversity and the potential origin for SEOV. However, the expanding endemic foci in the province suggest that the virus is spreading over a wider region and is much more diverse than previous depicted, which means that increased sampling is necessary.<\/jats:p>","DOI":"10.1371\/journal.pntd.0012478","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T17:22:46Z","timestamp":1726161766000},"page":"e0012478","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["The discovery of novel variants reveals the genetic diversity and potential origin of Seoul orthohantavirus"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2991-4538","authenticated-orcid":true,"given":"Guopeng","family":"Kuang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weichen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genyang","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7644-8464","authenticated-orcid":true,"given":"Zihou","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"issue":"8","key":"pntd.0012478.ref001","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nrmicro3066","article-title":"Uncovering the mysteries of hantavirus infections","volume":"11","author":"A Vaheri","year":"2013","journal-title":"Nat Rev Microbiol"},{"key":"pntd.0012478.ref002","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.virusres.2014.01.008","article-title":"Evolution of hantaviruses: co-speciation with reservoir hosts for more than 100 MYR","volume":"187","author":"A Plyusnin","year":"2014","journal-title":"Virus Res"},{"key":"pntd.0012478.ref003","unstructured":"International Committee on Taxonomy of Viruses. ICTV report on virus taxonomy [Internet]. 2023 [cited 2024 Aug 24]. 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