{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T11:10:15Z","timestamp":1767179415872,"version":"build-2238731810"},"update-to":[{"DOI":"10.1371\/journal.pntd.0012491","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000}}],"reference-count":22,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["949963"],"award-info":[{"award-number":["949963"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>\n                    We assessed the impact of loiasis and its treatment with ivermectin on hemostasis and inflammation in 38 adults in Cameroon. Participants were divided into four balanced groups based on their\n                    <jats:italic>Loa loa<\/jats:italic>\n                    microfilarial densities. At baseline, eosinophils and platelets increased with microfilarial densities (p&lt;0.001 and p = 0.044, respectively). At day 4 following ivermectin administration, median eosinophils rose from 171\/\u03bcL to 1,095\/\u03bcL (p&lt;0.001) and median D-dimers increased from 582 ng\/mL to 745 ng\/mL (p = 0.024) with a median relative variation of +34.7%. C-reactive protein, fibrinogen, and alpha-1-globulin also increased significantly after treatment. Ivermectin treatment appeared to induce inflammation, coagulation activation and fibrinolysis.\n                  <\/jats:p>","DOI":"10.1371\/journal.pntd.0012491","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T13:40:12Z","timestamp":1734356412000},"page":"e0012491","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inflammation and hemostasis in loiasis before and after ivermectin treatment: A biological pilot cross-sectional study"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1710-2110","authenticated-orcid":true,"given":"Tristan M.","family":"Lepage","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narcisse","family":"Nzune-Toche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie A.","family":"Nkwengoua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugues C.","family":"Nana-Djeunga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastien D. 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