{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T20:07:02Z","timestamp":1781813222829,"version":"3.54.5"},"update-to":[{"DOI":"10.1371\/journal.pntd.0012619","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000}}],"reference-count":73,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FIS AESI PI21CIII\/00031"],"award-info":[{"award-number":["FIS AESI PI21CIII\/00031"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"BESCOS-MANAU FAMILY"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Some regions of Spain are withdrawing their pregnancy screening program for congenital toxoplasmosis (CT). The Spanish Research Network of Congenital Toxoplasmosis (REIV-TOXO) was created to describe the current status of CT in Spain. The aims of this study were to describe the epidemiological and clinical characteristics of CT and to evaluate the effect of prenatal treatment on clinical outcomes to inform decision-making policies.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Ambispective observational study including CT cases recorded in the REIV-TOXO database that includes 122 hospitals (2015\u20132022). Inclusion criteria were one or more of the following: positive PCR in maternal amniotic fluid; positive <jats:italic>Toxoplasma gondii<\/jats:italic>-specific IgM or IgA antibodies at birth; positive PCR in the placenta, newborn blood, urine or CSF; increase of specific IgG levels during infant follow-up; or specific IgG persistence beyond age 12 months.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Findings<\/jats:title>\n<jats:p>Fifty-six newborns (54 pregnancies) were included. Prenatal screening allowed 92.8% of cases to be identified. The time of maternal infection was well documented in 90.7% of cases, with 61.1% occurring in the third trimester. A total of 66.6% (36\/54) pregnant women received antiparasitic treatment: 24\/36 spiramycin, 8\/36 pyrimethamine, sulfadiazine, and folinic acid, and 4\/36 both treatments sequentially. Most cases were asymptomatic at birth (62.5%, 35\/56), and 84% (47\/56) newborns completed one year of treatment. Median follow-up was 24 months (IQR = 3\u201372): 14.2% children exhibited new complications, mainly ocular. Newborns born to mothers treated prenatally had four-fold lower risk of CT clinical features at birth (p = 0.03) and six-fold lower risk of further complications during follow-up (p = 0.04) with no treatment-related differences during pregnancy.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>While diagnosis based only on neonatal assessment misses a significant number of CT cases, prenatal screening allows treatment to be started during pregnancy, with better clinical outcomes at birth and during follow-up. REIV-TOXO provides valuable information about CT in Spain, highlighting the need for universal maternal screening.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pntd.0012619","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T17:38:41Z","timestamp":1729618721000},"page":"e0012619","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["REIV-TOXO Project: Results from a Spanish cohort of congenital toxoplasmosis (2015\u20132022). The beneficial effects of prenatal treatment on clinical outcomes of infected newborns"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8601-0191","authenticated-orcid":true,"given":"Borja","family":"Guarch-Ib\u00e1\u00f1ez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Carreras-Abad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Antoinette","family":"Frick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Bl\u00e1zquez-Gamero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Baquero-Artigao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Fuentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Spanish Research Network of Congenital Toxoplasmosis (REIV-TOXO) group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pere","family":"Soler-Palacin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"issue":"2","key":"pntd.0012619.ref001","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1128\/CMR.05013-11","article-title":"Epidemiology of and diagnostic strategies for toxoplasmosis","volume":"25","author":"F Robert-Gangneux","year":"2012","journal-title":"Clin Microbiol Rev"},{"issue":"29","key":"pntd.0012619.ref002","doi-asserted-by":"crossref","first-page":"E6956","DOI":"10.1073\/pnas.1722202115","article-title":"Human impact on the diversity and virulence of the ubiquitous zoonotic parasite Toxoplasma gondii","volume":"115","author":"EK Shwab","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9425","key":"pntd.0012619.ref003","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/S0140-6736(04)16412-X","volume":"363","author":"JG Montoya","year":"2004","journal-title":"Toxoplasmosis. 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