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These restrictions have also played a significant role in controlling the spread of other diseases, including those that do not require direct contact between individuals for transmission, such as dengue. In this study, we investigate the impact of human mobility on the dynamics of dengue transmission in a large metropolis. We compare data on the spread of the disease over a nine-year period with data from 2020 when strict mobility restrictions were in place. This comparison enables us to accurately assess how mobility restrictions have influenced the rate of dengue propagation and their potential for preventing an epidemic year. We observed a delay in the onset of the disease in some neighborhoods and a decrease in cases in the initially infected areas. Using a predictive model based on neural networks capable of estimating the potential spread of the disease in the absence of mobility restrictions for each neighborhood, we quantified the change in the number of cases associated with social distancing measures. Our findings with this model indicate a substantial reduction of approximately 72% in dengue cases in the city of Fortaleza throughout the year 2020. Additionally, using an Interrupted Time Series (ITS) model, we obtained results showing a strong correlation between the prevention of dengue and low human mobility, corresponding to a reduction of approximately 45% of cases. Despite the differences, both models point in the same direction, suggesting that urban mobility is a factor strongly associated with the pattern of dengue spread.<\/jats:p>","DOI":"10.1371\/journal.pntd.0012644","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T18:45:47Z","timestamp":1732560347000},"page":"e0012644","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["The impact of COVID-19 mobility restrictions on dengue transmission in urban areas"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5101-6246","authenticated-orcid":true,"given":"Jorge L. B.","family":"Ara\u00fajo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Bomfim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar I. 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