{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:04:28Z","timestamp":1787954668066,"version":"build-2784847793"},"reference-count":87,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372283"],"award-info":[{"award-number":["82372283"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072307"],"award-info":[{"award-number":["82072307"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Three-Year Initiative Plan for Strengthening Public Health System Construction in Shanghai Key Discipline Project","award":["GWVI-11.1-12"],"award-info":[{"award-number":["GWVI-11.1-12"]}]},{"name":"the Three-Year Initiative Plan for Strengthening Public Health System Construction in Shanghai Key Discipline Project","award":["GWV-10.1-XK13"],"award-info":[{"award-number":["GWV-10.1-XK13"]}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>\n                    <jats:italic>Echinococcus granulosus<\/jats:italic>\n                    , a zoonotic parasite, can severely damage host health or even lead to host death. In humans, early diagnosis of\n                    <jats:italic>E<\/jats:italic>\n                    .\n                    <jats:italic>granulosus<\/jats:italic>\n                    infection is difficult because the initial stages of the infection tend to be asymptomatic, this delays treatment and worsens prognosis in most patients. Herein, we present a comprehensive, temporal proteomic atlas of the liver at three stages of\n                    <jats:italic>E<\/jats:italic>\n                    .\n                    <jats:italic>granulosus<\/jats:italic>\n                    infection and analyze the changes in the proteome of host focal lesions; this atlas may provide an overview of the effects of\n                    <jats:italic>E<\/jats:italic>\n                    .\n                    <jats:italic>granulosus<\/jats:italic>\n                    in the host, as well as the interactions between them. We identified 3,197 proteins from mice model at 1, 3, and 6 months after\n                    <jats:italic>E<\/jats:italic>\n                    .\n                    <jats:italic>granulosus<\/jats:italic>\n                    infection; of these proteins, 760 were differentially expressed (520 upregulated; 240 downregulated). Moreover, 228 differentially expressed proteins were screened through cluster analysis and classified into four clusters according to their changing trends. Subsequently, candidate molecules related to cyst invasion, growth, candidate pathways and proteins related to angiogenesis were noted to demonstrate important value in mouse liver. Next, we used western blotting to verify the presence of the aforementioned proteins in mouse liver. In the later stages,\n                    <jats:italic>E<\/jats:italic>\n                    .\n                    <jats:italic>granulosus<\/jats:italic>\n                    infection was noted to result in significant enrichment of crucial proteins facilitating protoscoleces growth and development and inhibition of amino acid and lipid metabolic enzyme expression in mouse liver; it was also noted to transform host metabolism by weakening oxidative phosphorylation and enhancing glycolysis. In conclusion, we explored the molecular mechanisms underlying the parasitic processes of\n                    <jats:italic>E<\/jats:italic>\n                    .\n                    <jats:italic>granulosus<\/jats:italic>\n                    through proteomic analysis. Our results provide evidence that may enable the exploration of core regulatory targets for early and effective diagnosis and immunotherapy of\n                    <jats:italic>E<\/jats:italic>\n                    .\n                    <jats:italic>granulosus<\/jats:italic>\n                    infection, as well as parasite\u2013host interactions involved in cystic echinococcosis development.\n                  <\/jats:p>","DOI":"10.1371\/journal.pntd.0012659","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T13:37:08Z","timestamp":1733233028000},"page":"e0012659","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Proteomic analysis of mouse liver lesions at all three stages of Echinococcus granulosus infection"],"prefix":"10.1371","volume":"18","author":[{"given":"Nan","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeting","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxin","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujuan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1974-0047","authenticated-orcid":true,"given":"Jianping","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"issue":"5","key":"pntd.0012659.ref001","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.pt.2020.02.004","article-title":"Reinventing the Wheel of Echinococcus granulosus sensu lato transmission to humans","volume":"36","author":"F Tamarozzi","year":"2020","journal-title":"Trends Parasitol"},{"issue":"5","key":"pntd.0012659.ref002","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.3201\/eid2905.221828","article-title":"Cystic echinococcosis in Northern New Hampshire, USA","volume":"29","author":"A AlSalman","year":"2023","journal-title":"Emerg Infect Dis"},{"issue":"Suppl 1","key":"pntd.0012659.ref003","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s11259-009-9247-y","article-title":"Echinococcosis: costs, losses and social consequences of a neglected zoonosis","volume":"33","author":"G. 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