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Tick bites can lead to Lyme disease, forest encephalitis, and other illnesses that may result in death under severe circumstances. Materials and methods: Ticks collected from March 2021 to May 2023 were pooled and used in metatranscriptomic analyses to gain insight into the diversity and distribution of tick-borne viruses in Inner Mongolia. Next-generation sequencing (NGS) outcomes were validated, and viral prevalence across distinct tick species was determined through the application of polymerase chain reaction (PCR) paired with Sanger sequencing.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 20 RNA viruses belonging to at least 8 families, including <jats:italic>Chuviridae<\/jats:italic>, <jats:italic>Flaviviridae<\/jats:italic>, <jats:italic>Solemoviridae<\/jats:italic>, <jats:italic>Nairoviridae<\/jats:italic>, <jats:italic>Partitiviridae<\/jats:italic>, <jats:italic>Phenuiviridae<\/jats:italic>, <jats:italic>Rhabdoviridae<\/jats:italic>, and <jats:italic>Totiviridae<\/jats:italic>, and to unclassified families were identified by NGS. Five of the identified RNA viruses (Nuomin virus, Yezo virus, tick-borne encephalitis virus, Alongshan virus, and Beiji nairovirus) are considered human pathogens. A potential human pathogen, Mukawa virus, was also among the identified viruses. <jats:italic>Ixodes persulcatus<\/jats:italic> carried a significantly greater number of viral species than did <jats:italic>Dermacentor nuttalli<\/jats:italic>, <jats:italic>Hyalomma marginatum<\/jats:italic>, and <jats:italic>Haemaphysalis concinna<\/jats:italic>. The prevalence of coinfection with multiple viruses differed in <jats:italic>I<\/jats:italic>. <jats:italic>persulcatus<\/jats:italic> from Hinggan League and Hulun Buir, and Beiji nairovirus was the codominant virus species.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>There is a remarkable diversity of RNA viruses harboured by ticks in Inner Mongolia, with variations observed in the distribution of these tick-borne viruses across different regions and tick hosts.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pntd.0012706","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T18:27:15Z","timestamp":1733941635000},"page":"e0012706","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Metatranscriptomic analysis reveals the diversity of RNA viruses in ticks in Inner Mongolia, 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