{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T23:10:22Z","timestamp":1785193822813,"version":"3.55.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0012739","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000}}],"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","award":["442842\/2019-8"],"award-info":[{"award-number":["442842\/2019-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","award":["309252\/2021-0, 303459\/2022-0, 317328\/2021-2"],"award-info":[{"award-number":["309252\/2021-0, 303459\/2022-0, 317328\/2021-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Minas Gerais Research Funding Foundation","award":["PPM-00604-17"],"award-info":[{"award-number":["PPM-00604-17"]}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>Malaria is a mosquito-borne infectious disease caused by protozoa of the genus <jats:italic>Plasmodium<\/jats:italic>. Despite of the progress in malaria control in the last decades, malaria remains a major public health problem, contributing to increased morbidity and mortality in tropical and subtropical countries. Among American countries, Bolivia, Venezuela, and Brazil account for 73% of the cases. In Brazil, the majority of malaria cases is concentrated in Amazon region. This study estimated health-related quality of life (HRQoL) losses due to malaria in endemic areas of the Brazilian Amazon using the EQ-5D-3L instrument. We collected data from a convenience sample of 1,179 individuals aged 18 years or older. To measure the HRQoL loss, we matched individuals from the treatment group (with recent malaria) to those from the control group (without recent malaria) using Propensity Score Matching (PSM) and compared the difference in mean health utility between the groups. The results show a significant loss of HRQoL due to malaria. The mean utility was 0.69 and 0.83 for the treatment and control groups, respectively, representing a loss of quality of life of approximately 16.3% for individuals with recent malaria episodes. These findings underscore the importance of effective malaria prevention and treatment strategies, especially in areas where adverse socioeconomic conditions and a challenging epidemiological context exacerbate the impact of the disease. Continued investment in malaria control programs and improved access to health services are essential to mitigate the negative impact of this disease on the quality of life of affected populations.<\/jats:p>","DOI":"10.1371\/journal.pntd.0012739","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T18:56:08Z","timestamp":1734634568000},"page":"e0012739","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Health-Related Quality of Life due to malaria in the Brazilian Amazon using EQ-5D-3L"],"prefix":"10.1371","volume":"18","author":[{"given":"M\u00f4nica Viegas","family":"Andrade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenya Valeria Micaela","family":"de Souza Noronha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilvan Ramalho","family":"Guedes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayara Abreu","family":"Juli\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Resende","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ria Andrade","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre Soares","family":"Motta-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique","family":"Bracarense","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e1ssio","family":"Peterka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4606-2795","authenticated-orcid":true,"given":"Marcia C.","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"pntd.0012739.ref001","doi-asserted-by":"crossref","DOI":"10.30875\/f309483f-en","volume-title":"World malaria report 2018","author":"World Health Organization.","year":"2018"},{"key":"pntd.0012739.ref002","author":"World malaria report 2023.","year":"2023"},{"key":"pntd.0012739.ref003","unstructured":"Dia da Mal\u00e1ria nas Am\u00e9ricas\u2014um panorama da mal\u00e1ria no Brasil em 2022 e no primeiro semestre de 2023. 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Gold miners augment malaria transmission in indigenous territories of Roraima state","author":"J de Aguiar Barros","year":"2022","journal-title":"Brazil. Malaria Journal"},{"key":"pntd.0012739.ref009","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.vhri.2019.08.478","article-title":"Evaluation of Psychometric Quality of EQ-5D-5L Scale for Assessing Health-Related Quality of Life of Malaria Patients.","author":"NS Jimam","year":"2020","journal-title":"Value in health regional issues."},{"key":"pntd.0012739.ref010","article-title":"Measurement of Health Related Quality of Life in Malaria Patients in Indonesia using EQ-5D-5","author":"DA Makatita","year":"2019","journal-title":"L. 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Diretrizes Metodol\u00f3gicas: Qualidade de Vida em An\u00e1lises Econ\u00f4micas. 2023."},{"key":"pntd.0012739.ref019","first-page":"1","article-title":"Health-related quality of life in the Brazilian Amazon: a population-based cross-sectional study.","author":"MT Silva","year":"2017","journal-title":"Health and quality of life outcomes."},{"key":"pntd.0012739.ref020","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1590\/S0074-02762007005000098","article-title":"Chagas disease in the Amazon Region.","author":"HM Aguilar","year":"2007","journal-title":"Mem\u00f3rias do Instituto Oswaldo Cruz."},{"key":"pntd.0012739.ref021","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.jiph.2023.02.012","article-title":"Malarial and intestinal parasitic co-infections in indigenous populations of the Brazilian Amazon rainforest","author":"MPA Vasconcelos","year":"2023","journal-title":"Journal of Infection and Public Health"},{"key":"pntd.0012739.ref022","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1590\/0074-02760160150","article-title":"High malaria transmission in a forested malaria focus in French Guiana: How can exophagic Anopheles darlingi thwart vector control and prevention measures?","author":"SB Vezenegho","year":"2016","journal-title":"Mem\u00f3rias do Instituto Oswaldo Cruz."},{"key":"pntd.0012739.ref023","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s13071-023-05759-4","article-title":"Evaluation of Long-lasting insecticidal nets (LLINs) for malaria control in an endemic area in Brazil.","author":"AC da Silva Ferreira Lima","year":"2023","journal-title":"Parasites & Vectors."},{"key":"pntd.0012739.ref024","first-page":"1","article-title":"Evaluation of the effect of supervised anti-malarial treatment on recurrences of Plasmodium vivax malaria","author":"KMO Dinelly","year":"2021","journal-title":"Malaria journal"},{"key":"pntd.0012739.ref025","first-page":"1","article-title":"Use and retention of long-lasting insecticidal nets (LLINs) in a malaria risk area in the Brazilian Amazon: a 5-year follow-up intervention.","author":"JdO Sousa","year":"2019","journal-title":"Malaria journal"},{"key":"pntd.0012739.ref026","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1590\/0037-8682-0275-2015","article-title":"Factors associated with non-adherence to the treatment of vivax malaria in a rural community from the Brazilian Amazon Basin.","author":"ED Almeida","year":"2016","journal-title":"Revista da Sociedade Brasileira de Medicina Tropical."},{"key":"pntd.0012739.ref027","first-page":"1","article-title":"Adherence to Plasmodium vivax malaria treatment in the Brazilian Amazon Region","author":"EA Pereira","year":"2011","journal-title":"Malaria journal"},{"key":"pntd.0012739.ref028","doi-asserted-by":"crossref","first-page":"796027","DOI":"10.3389\/fphar.2022.796027","article-title":"Methods to assess adult and adolescent patients\u2019 adherence to antimalarial treatment: A systematic review.","author":"HFP Santos","year":"2022","journal-title":"Frontiers in Pharmacology"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0012739","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0012739","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T21:56:02Z","timestamp":1735941362000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0012739"}},"subtitle":[],"editor":[{"given":"Claudia Ida","family":"Brodskyn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,12,19]]},"references-count":28,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0012739","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0012739","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,19]]}}}