{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T23:42:45Z","timestamp":1777333365564,"version":"3.51.4"},"update-to":[{"DOI":"10.1371\/journal.pntd.0012773","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000}}],"reference-count":18,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000200","name":"United States Agency for International Development","doi-asserted-by":"publisher","award":["grant OAA-13-000008"],"award-info":[{"award-number":["grant OAA-13-000008"]}],"id":[{"id":"10.13039\/100000200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000200","name":"United States Agency for International Development","doi-asserted-by":"publisher","award":["Cooperative agreement #7200AA18CA00011"],"award-info":[{"award-number":["Cooperative agreement #7200AA18CA00011"]}],"id":[{"id":"10.13039\/100000200","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      As part of a multi-country evaluation, the SD Biosensor STANDARD Q Filariasis Antigen Test (QFAT) was compared with the Abbott Bioline Filariasis Test Strip (FTS) for assessing\n                      <jats:italic>\n                        <jats:italic>Wuchereria bancrofti<\/jats:italic>\n                      <\/jats:italic>\n                      infection prevalence and for ease of use of QFAT in field conditions in Sierra Leone.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods and principal findings<\/jats:title>\n                    <jats:p>\n                      The evaluation was done in two districts, Bombali and Karene, where repeat pre-transmission assessment surveys (pre-TAS) were planned. Two rural sites, Kagbo and Makorba Yelimini which recorded high LF antigen prevalence of 4.1% and 7.7% respectively in repeat pre-TAS in 2020 were selected for the QFAT evaluation. At least 350 people \u22655 years were targeted per site for inclusion in the study by convenience sampling. Blood was collected by fingerstick; 20\u03bcl for QFAT and 75\u03bcl for FTS. The reading time for both tests was 10 minutes. For all positive or invalid results, a repeat test was performed for both tests. In total, 728 participants (5\u201391 years) were tested by QFAT and FTS. Four FTS and three QFAT final results were classified as indeterminate (meaning a positive result followed by a negative result) and were excluded from the analysis. The positive rate was 4.8% (17\/357) and 3.5% (13\/367) for FTS and 3.4% (12\/359) and 4.1% (15\/366) for QFAT in Kagbo and Makorba Yelimi, respectively. All participants testing positive for FTS or QFAT underwent further testing by night blood smear to detect microfilariae using microscopy. No\n                      <jats:italic>\n                        <jats:italic>W. bancrofti<\/jats:italic>\n                      <\/jats:italic>\n                      microfilariae was detected in any of the antigen positive cases. In field conditions, QFAT was easy to handle and recorded zero invalid tests compared to FTS (six invalids). The concordance between FTS and QFAT was 0.81 (Cohen\u2019s Kappa). The discrepancy found between the two tests in terms of positive tests was not statistically significant (p\u2009=\u20090.78).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Conclusions\/significance<\/jats:title>\n                    <jats:p>\n                      The results suggest that the QFAT is a credible\n                      <jats:italic>\n                        <jats:italic>W. bancrofti<\/jats:italic>\n                      <\/jats:italic>\n                      diagnostic test when compared to the routinely used FTS; use of either test would result in the same program decision.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0012773","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T17:56:51Z","timestamp":1753725411000},"page":"e0012773","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Field evaluation of Standard Q Filariasis Antigen Test for Lymphatic Filariasis (LF) during a pre-transmission assessment survey in Sierra Leone, 2022"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6712-310X","authenticated-orcid":true,"given":"Benoit","family":"Dembele","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Salieu","family":"Bah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulai","family":"Conteh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Habib I.","family":"Kamara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Kargbo-Labour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Houck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernest O.","family":"Mensah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Turay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric Scott","family":"Elder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Gass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven D.","family":"Reid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph P.","family":"Shott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaobi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly Y.","family":"Won","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Weaver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"key":"pntd.0012773.ref001","unstructured":"Organization WH. Global programme to eliminate lymphatic filariasis: progress report, 2022. Weekly Epidemiological Record (WER). 2023;No 41, 2023, 98;489\u2013502."},{"key":"pntd.0012773.ref002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13071-018-2649-3","article-title":"Human infection with sub-periodic Brugia spp. in Gampaha District, Sri Lanka: a threat to filariasis elimination status?","volume":"11","author":"CH Mallawarachchi","year":"2018","journal-title":"Parasites & Vectors"},{"key":"pntd.0012773.ref003","unstructured":"(WHO) WHO. Lymphatic filariasis: World Helath Organization (WHO). 2024. 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