{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:57:11Z","timestamp":1790402231017,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0012896","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000}}],"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005527","name":"Carter Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005527","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>\n                    <jats:italic>Dracunculus medinensis<\/jats:italic>\n                    (Guinea worm; GW) is a parasitic nematode that causes dracunculiasis (Guinea worm disease; GWD). The annual incidence of GWD in humans has been reduced by over 99.9% globally since the 1980s thanks to the implementation of complementary interventions. Dogs are now the primary hosts of GW and impede eradication efforts. The antihelmenthic drug, flubendazole (FLBZ), was suggested as a possible therapeutic intervention after it was found to be partially effective at reducing fertility of\n                    <jats:italic>D. medinensis<\/jats:italic>\n                    in experimentally infected ferrets. A 2019 clinical trial of FLBZ in Chad found no statistically significant difference in GW infections between treated and control dogs, but longer term effects may be observed if FLBZ reduced fertility of\n                    <jats:italic>D. medinensis.<\/jats:italic>\n                    This study leveraged surveillance data from the National Guinea Worm Eradication Program of the monthly count of\n                    <jats:italic>D. medinensis<\/jats:italic>\n                    worms in dogs between January 1, 2019, and September 30, 2021, for 56 villages to examine whether FLBZ would have an observable effect over 33 months and in the presence of another intervention, proactive tethering. We fit hypothesis-informed models of the combined interventions using negative binomial generalized linear mixed models. We averaged the top models together and predicted the number of\n                    <jats:italic>D. medinensis<\/jats:italic>\n                    infections per month for an average village. Based on the model predictions, we observed a clear delineation of effects between March and August 2021, approximately one year after most villages initiated proactive tethering and approximately two years after a few villages initiated FLBZ treatment. During this period, the predicted number of dog infections were reduced by 83% (95% CI, 76% to 88%) when using FLBZ and proactive tethering concurrently, by 63% when using FLBZ alone (95% CI: 44% to 75%), and by 55% when using proactive tethering alone (95% CI: 52% to 58%) compared to baseline control methods. When used together, proactive tethering and FLBZ may be important tools in reducing the village-level\n                    <jats:italic>D. medinensis<\/jats:italic>\n                    burden in dogs.\n                  <\/jats:p>","DOI":"10.1371\/journal.pntd.0012896","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T18:55:42Z","timestamp":1770058542000},"page":"e0012896","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Concurrent therapeutic and behavioral interventions are associated with a reduced number of emerging Dracunculus medinensis worms in dogs in Chad"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8994-492X","authenticated-orcid":true,"given":"Amy C.","family":"Dupper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Cleveland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen K.","family":"Haynes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Yabsley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Torres-Velez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9tinou Koum\u00e9tio","family":"Sidouin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip Tchindebet","family":"Oaukou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Garabed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"issue":"4","key":"pntd.0012896.ref001","doi-asserted-by":"crossref","first-page":"511","DOI":"10.4269\/ajtmh.1971.20.511","article-title":"Concerning the structure and reproduction of the Guinea worm (Filaria medinensis). 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