{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T20:19:24Z","timestamp":1780345164457,"version":"3.54.1"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI116456"],"award-info":[{"award-number":["R01AI116456"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","award":["D43TW001140"],"award-info":[{"award-number":["D43TW001140"]}],"id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Calcified neurocysticercosis (NCC), the end stage of brain cysts of the pork tapeworm <jats:italic>Taenia solium<\/jats:italic> is a common cause of epilepsy. Calcified NCC lesions are not inert and represent potential epileptogenic foci. Understanding the mechanisms of residual calcification in NCC is hindered by the difficulty of accessing human brain biopsies. Since cyst degeneration can be induced by antiparasitic treatment (APT) in NCC\u2013infected pigs, this study assessed the residual calcification process in this model at three time points after APT.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods\/Principal findings<\/jats:title>\n<jats:p>Fifteen naturally infected pigs with viable NCC confirmed by magnetic resonance imaging received APT with albendazole and praziquantel and were sacrificed after 4, 8, and 12 months (<jats:italic>n<\/jats:italic>\u2009=\u20095 each). The pigs\u2019 brains were removed and processed by ex vivo CT scan to assess the proportion of cysts that calcified by post\u2013treatment time points using risk ratios (RR) from Poisson regression. Radiodensity levels (Hounsefield units) of calcified lesions were also measured and compared using linear coefficients from log\u2013transformed values in generalized linear models. The overall proportion of residual calcification on CT scan was 63.9% (156 calcified lesions\/244 viable cysts), being statistically higher in treated NCC pigs at 4 months (83.3% [50\/60], RR\u2009=\u20092.61, <jats:italic>P\u2009<\/jats:italic>&lt;\u20090.001) and 8 months (82.8% [77\/93], RR\u2009=\u20092.59, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) versus 12 months (31.9% [29\/91]). At 8 months after APT, calcifications were more dense (100.6\u2009\u00b1\u20093.6 HU) compared to 12 months (74.4\u2009\u00b1\u20093.6 HU, \u03b2\u2009<jats:italic>=\u2009<\/jats:italic>0.37, <jats:italic>P<\/jats:italic>\u2009=\u20090.010) and marginally higher compared to 4 months (85.2\u2009\u00b1\u20093.8 HU, \u03b2\u2009=\u20090.24, <jats:italic>P<\/jats:italic>\u2009=\u20090.096), and were also larger and more frequently found on histopathology.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Conclusion\/Significance<\/jats:title>\n<jats:p>Calcification in NCC is a dynamic process that can be induced and monitored in naturally infected pigs. Eight months after treatment seems to be an optimal time point for assessing residual calcification.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pntd.0013022","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T17:22:32Z","timestamp":1746465752000},"page":"e0013022","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["The process of residual calcification following antiparasitic treatment in the pig model of neurocysticercosis is 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