{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T01:21:55Z","timestamp":1785374515813,"version":"3.55.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0013033","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000}}],"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018707","name":"HORIZON EUROPE Reforming and enhancing the European Research and Innovation system","doi-asserted-by":"publisher","award":["734584"],"award-info":[{"award-number":["734584"]}],"id":[{"id":"10.13039\/100018707","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wellcome Trust and the UK Department for International Development","award":["201870 \/ Z \/ 16 \/ Z and 205377 \/ Z \/ 16 \/ Z;"],"award-info":[{"award-number":["201870 \/ Z \/ 16 \/ Z and 205377 \/ Z \/ 16 \/ Z;"]}]},{"name":"Wellcome Trust \u2013 Research Enrichment in Epidemic Situations","award":["107779\/Z\/15\/Z; ER1505"],"award-info":[{"award-number":["107779\/Z\/15\/Z; ER1505"]}]},{"name":"Wellcome Trust \u2013 Research Enrichment in Epidemic Situations","award":["107779\/Z\/15\/Z; ER1601"],"award-info":[{"award-number":["107779\/Z\/15\/Z; ER1601"]}]},{"name":"Medical Research Council on behalf of the Newton Fund and Wellcome Trust","award":["MC_PC_15088"],"award-info":[{"award-number":["MC_PC_15088"]}]},{"DOI":"10.13039\/501100006507","name":"Funda\u00e7\u00e3o Oswaldo Cruz","doi-asserted-by":"publisher","award":["HHSN275201800001"],"award-info":[{"award-number":["HHSN275201800001"]}],"id":[{"id":"10.13039\/501100006507","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pan American Health Organization and Improvement of Research Activity in Epidemic Situations (for the MERG Case Control Study"},{"name":"Foundation for Support to Science and Technology of PE\u2014FACEPE","award":["APQ-0192\u20134.01 \/ 17, APQ-0172\u20134.01\/16"],"award-info":[{"award-number":["APQ-0192\u20134.01 \/ 17, APQ-0172\u20134.01\/16"]}]},{"name":"Coordination for the Improvement of Higher Education Personnel\u2014Brazil (CAPES","award":["Financial Code 001"],"award-info":[{"award-number":["Financial Code 001"]}]},{"name":"National Council for Scientifc and Technological Development","award":["309722 \/ 2017\u20139"],"award-info":[{"award-number":["309722 \/ 2017\u20139"]}]},{"name":"National Council for Scientifc and Technological Development","award":["306708 \/ 2014\u20130"],"award-info":[{"award-number":["306708 \/ 2014\u20130"]}]},{"name":"Brazilian Ministry of Health Public Health Emergency Response \u2014 Zika virus and Microcephaly","award":["837058\/2016"],"award-info":[{"award-number":["837058\/2016"]}]},{"name":"National Council for Scientifc and Technological Development, Coordination for the Improvement of Higher Education Personnel ; Department of Science and Technology","award":["440839 \/ 2016\u20135"],"award-info":[{"award-number":["440839 \/ 2016\u20135"]}]},{"name":"Wellcome Collaborative Award entitled \u201cLong-term consequences of Zika virus infections during pregnancy for school-aged children and their families in Brazil\u201d","award":["224494\/B\/21\/Z."],"award-info":[{"award-number":["224494\/B\/21\/Z."]}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>Zika virus (ZIKV) infection during pregnancy can lead to Congenital Zika Syndrome (CZS), with significant impacts on early childhood development. This study aimed to analyze the natural history of hearing loss in children with CZS during their first four years of life. Data were collected from the Microcephaly Epidemic Research Group Pediatric Cohort in Pernambuco, Brazil. We investigated whether children with prenatal ZIKV exposure could develop late-onset hearing loss and whether those with preserved auditory thresholds at birth might exhibit deficits in functional hearing or primary language development.The study included children with suspected or confirmed prenatal ZIKV exposure who had normal neonatal hearing screenings. Follow-up assessments included auditory brainstem response testing and behavioral observational audiometry. Children were evaluated every six months up to 24 months of age and annually thereafter until 48 months. Results indicated that late-onset sensorineural hearing loss (SNHL) was not observed in children with prenatal ZIKV exposure and normal neonatal hearing screening. The hearing losses identified were transient and typically related to middle ear effusion. Therefore, our findings reinforce that congenital SNHL associated with ZIKV exposure predominantly manifests at birth, with no evidence supporting its late onset in the first years of life.<\/jats:p>","DOI":"10.1371\/journal.pntd.0013033","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T17:29:56Z","timestamp":1745602196000},"page":"e0013033","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Late-onset hearing loss was not observed among preschool- aged children with prenatal Zika virus exposure: An analysis of the Microcephaly Epidemic Research Group Pediatric Cohort (2015\u20132019)"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5876-1158","authenticated-orcid":true,"given":"Danielle Seabra","family":"Ramos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian","family":"Ferreira Muniz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"de Carvalho Leal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dem\u00f3crito de Barros","family":"Miranda Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Arraes de Alencar","family":"Ximenes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Brickley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thalia Velho Barreto","family":"de Araujo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celina Maria Turchi","family":"Martelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio da Silva","family":"Caldas Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"issue":"10","key":"pntd.0013033.ref001","article-title":"The microcephaly epidemic and Zika virus: building knowledge in epidemiology","volume":"34","author":"FPM Albuquerque M de","year":"2018","journal-title":"Cad Saude Publica"},{"key":"pntd.0013033.ref002","author":"Brasil. 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