{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:19:46Z","timestamp":1787062786234,"version":"build-2736575974"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Research and Development Program in Hainan Province","award":["ZDYF2024SHFZ083"],"award-info":[{"award-number":["ZDYF2024SHFZ083"]}]},{"name":"National Key R & D Project","award":["2021YFC2300800"],"award-info":[{"award-number":["2021YFC2300800"]}]},{"name":"National Key R & D Project","award":["2021YFC2300804"],"award-info":[{"award-number":["2021YFC2300804"]}]},{"name":"Technology Innovation Support Program, NIPD, China CDC","award":["TF2024012"],"award-info":[{"award-number":["TF2024012"]}]},{"DOI":"10.13039\/501100011338","name":"Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education","doi-asserted-by":"publisher","award":["NHCKFKT2021\u204312"],"award-info":[{"award-number":["NHCKFKT2021\u204312"]}],"id":[{"id":"10.13039\/501100011338","id-type":"DOI","asserted-by":"publisher"}]},{"name":"High-level health technical personnel in Yunnan Province","award":["H\u20432018073"],"award-info":[{"award-number":["H\u20432018073"]}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>\n                    We summarize historical events related to angiostrongyliasis and analyze surveys of clinically diagnosed and suspected cases of angiostrongyliasis in Dali from 2007 to 2021. We also randomly tested market sold\n                    <jats:italic>Pomacea<\/jats:italic>\n                    spp. snails to detect whether\n                    <jats:italic>Angiostrongylus cantonensis<\/jats:italic>\n                    was present in Dali market stalls from 2008 to 2021. There were a total of 125 cases of angiostrongyliasis (92 clinically diagnosed and 33 suspected) reported in the Dali Prefecture from 2007-2021. Of the 125 cases, 72 patients from 2010 to 2021 were investigated, with the main clinical manifestations being headache (100%), muscle pain (61%), neck stiffness (58.3%), paresthesia (58.3%), fever (55.5%), nausea (48.6%), coughing (26.3%), vomiting (44.4%), photophobia (18%), diplopia (25%), and visual impairment (5.5%). Laboratory testing showed cerebrospinal fluid qualitative protein levels and blood eosinophil levels were abnormal in 100% and 87.5% of patients tested, respectively. Moreover, of the 49,970\n                    <jats:italic>Pomacea<\/jats:italic>\n                    spp. checked for\n                    <jats:italic>A. cantonensis<\/jats:italic>\n                    infection, 373 (0.75%) were found infected. Our study highlights the importance of enhancing public education, stricter food safety measures, and improved diagnostic methods to help mitigate future outbreaks of angiostrongyliasis.\n                  <\/jats:p>","DOI":"10.1371\/journal.pntd.0013065","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T13:32:13Z","timestamp":1746451933000},"page":"e0013065","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Monitoring the trends of Angiostrongylus cantonensis infection in humans and Pomacea spp. Snails in Dali, Yunnan, China, 2007\u20132021"],"prefix":"10.1371","volume":"19","author":[{"given":"Tian-mei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-hua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen-hua","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter S.","family":"Andrus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6355-3727","authenticated-orcid":true,"given":"Yun-hai","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-rong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,5,5]]},"reference":[{"key":"pntd.0013065.ref001","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1051\/parasite\/1935134312","article-title":"Un nouveau n\u00e9matode pulmonaire, Pulmonema cantonensis, ng, n. sp. [A new lung nematode, Pulmonema cantonensis, ng, n. sp.]","volume":"13","author":"HT Chen","year":"1935","journal-title":"Ann Hum Comp Parasitol"},{"issue":"6 Suppl 2","key":"pntd.0013065.ref002","first-page":"6","article-title":"Biology, systematics, life cycle, and distribution of Angiostrongylus cantonensis, the cause of rat lungworm disease","volume":"72","author":"RH Cowie","year":"2013","journal-title":"Hawaii J Med Public Health"},{"issue":"4","key":"pntd.0013065.ref003","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s10096-011-1328-5","article-title":"Human Angiostrongylus cantonensis: an update","volume":"31","author":"Q-P Wang","year":"2012","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"5","key":"pntd.0013065.ref004","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.kjms.2010.12.013","article-title":"Eosinophilic meningitis risk associated with raw Ampullarium canaliculatus snails consumption","volume":"27","author":"J-J Wang","year":"2011","journal-title":"Kaohsiung J Med Sci"},{"issue":"7","key":"pntd.0013065.ref005","doi-asserted-by":"crossref","first-page":"771","DOI":"10.2169\/internalmedicine.50.4193","article-title":"Encephalitis caused by Angiostrongylus cantonensis after eating raw frogs mixed with wine as a health supplement","volume":"50","author":"H-C Tsai","year":"2011","journal-title":"Intern Med"},{"key":"pntd.0013065.ref006","doi-asserted-by":"crossref","first-page":"100426","DOI":"10.1016\/j.onehlt.2022.100426","article-title":"Paratenic hosts of Angiostrongylus cantonensis and their relation to human neuroangiostrongyliasis globally","volume":"15","author":"HC Turck","year":"2022","journal-title":"One Health"},{"issue":"6 Suppl 2","key":"pntd.0013065.ref007","first-page":"23","article-title":"The apple snail Pomacea canaliculata, a novel vector of the rat lungworm, Angiostrongylus cantonensis: its introduction, spread, and control in China","volume":"72","author":"T-B Yang","year":"2013","journal-title":"Hawaii J Med Public Health"},{"issue":"1","key":"pntd.0013065.ref008","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3201\/eid1401.061529","article-title":"Emerging angiostrongyliasis in Mainland China","volume":"14","author":"S Lv","year":"2008","journal-title":"Emerg Infect Dis"},{"issue":"3","key":"pntd.0013065.ref009","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s00436-015-4849-5","article-title":"Angiostrongylus cantonensis in the vector snails Pomacea canaliculata and Achatina fulica in China: a meta-analysis","volume":"115","author":"L Song","year":"2016","journal-title":"Parasitol Res"},{"issue":"2","key":"pntd.0013065.ref010","doi-asserted-by":"crossref","first-page":"e368","DOI":"10.1371\/journal.pntd.0000368","article-title":"Invasive snails and an emerging infectious disease: results from the first national survey on Angiostrongylus cantonensis in China","volume":"3","author":"S Lv","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0013065.ref011","first-page":"2","article-title":"\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u589e\u591a\u6027\u8111\u819c\u708e 28\u4f8b\u4e34\u5e8a\u5206\u6790 [Clinical analysis of 28 cases of eosinophilic meningoencephalitis]","volume":"1","author":"J Han","year":"2006","journal-title":"Chin J Pathogen Biol"},{"issue":"1","key":"pntd.0013065.ref012","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s40249-018-0482-8","article-title":"Small-scale spatial analysis of intermediate and definitive hosts of Angiostrongylus cantonensis","volume":"7","author":"Q-A Hu","year":"2018","journal-title":"Infect Dis Poverty"},{"key":"pntd.0013065.ref013","first-page":"137","article-title":"\u4e91\u5357\u7701\u5927\u7406\u5dde\u9996\u6b21\u5e7f\u5dde\u7ba1\u5706\u7ebf\u866b\u75c5\u75ab\u60c5\u8c03\u67e5\u4e0e\u5904\u7f6e [Investigation and management of the first outbreak of angiostrongyliasis in Guangzhou, Dali Prefecture, Yunnan Province]","volume":"6","author":"S Chen","year":"2008","journal-title":"Parasit Infect Dis"},{"key":"pntd.0013065.ref014","first-page":"167","article-title":"\u5e74\u5927\u7406\u5730\u533a\u5e7f\u5dde\u7ba1\u5706\u7ebf\u866b\u75c5\u76d1\u6d4b\u75c5\u4f8b\u5206\u6790 2010-2016 [Analysis of surveillance cases of human angiostrongyliasis in the Dali area from 2010 to 2016]","volume":"15","author":"T Li","year":"2017","journal-title":"J Trop Dis Parasitol"},{"key":"pntd.0013065.ref015","first-page":"64","article-title":"Interpretation to diagnosis criteria for angiostrongyliasis cantonensis","volume":"1","author":"Y Zhang","year":"2010","journal-title":"China Health Stand Manag"},{"key":"pntd.0013065.ref016","first-page":"53","article-title":"\u4e09\u79cd\u65b9\u6cd5\u68c0\u6d4b\u798f\u5bff\u87ba\u80ba\u56ca\u5185\u5e7f\u5dde\u7ba1\u5706\u7ebf\u866b\u6548\u679c\u7684\u6bd4\u8f83\u7814\u7a76 [A comparative study on the effect of three methods on the detection of Angiostrongylus cantonensis in the lung sac of Pomacea snails]","volume":"2","author":"H Liu","year":"2007","journal-title":"Chin J Parasitol Parasitic Dis"},{"issue":"1","key":"pntd.0013065.ref017","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1186\/s13071-024-06350-1","article-title":"A new diagnostic technique for identifying Angiostrongylus spp. larvae in intermediate snail species by examining the buccal cavity","volume":"17","author":"Y-B Zhao","year":"2024","journal-title":"Parasit Vectors"},{"issue":"1","key":"pntd.0013065.ref018","doi-asserted-by":"crossref","first-page":"176","DOI":"10.4269\/ajtmh.15-0146","article-title":"Real-time polymerase chain reaction detection of Angiostrongylus cantonensis DNA in cerebrospinal fluid from patients with eosinophilic meningitis","volume":"94","author":"Y Qvarnstrom","year":"2016","journal-title":"Am J Trop Med Hyg"},{"issue":"6","key":"pntd.0013065.ref019","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.3201\/eid2306.161683","article-title":"Angiostrongylus cantonensis Meningitis and Myelitis, Texas, USA","volume":"23","author":"R Al Hammoud","year":"2017","journal-title":"Emerg Infect Dis"},{"key":"pntd.0013065.ref020","author":"Ministry of Ecology and Environment of the People\u2019s Republic of China","year":"2003"},{"key":"pntd.0013065.ref021","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/j.1365-2427.2011.02579.x","article-title":"The emergence of angiostrongyliasis in the People\u2019s Republic of China: the interplay between invasive snails, climate change and transmission dynamics","volume":"56","author":"S Lv","year":"2011","journal-title":"Freshw Biol"},{"key":"pntd.0013065.ref022","first-page":"67","article-title":"\u6d31\u6d77\u5468\u8fb9\u798f\u5bff\u87ba\u5206\u5e03\u8c03\u67e5. [Distribution of Pomacea canaliculata around Erhai Lake]","volume":"8","author":"J Yan","year":"2009","journal-title":"J Dali Coll"},{"issue":"6","key":"pntd.0013065.ref023","first-page":"687","article-title":"Investigation on outbreak of angiostrongyliasis cantonensis due to consumption of snail food in Dali City","volume":"23","author":"F Chen","year":"2011","journal-title":"Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0013065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T13:32:23Z","timestamp":1746451943000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0013065"}},"subtitle":[],"editor":[{"given":"Siddhartha","family":"Mahanty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,5,5]]},"references-count":23,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0013065","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,5]]}}}