{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:12:25Z","timestamp":1789729945664,"version":"4.0.1"},"update-to":[{"DOI":"10.1371\/journal.pntd.0013073","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000}}],"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Lymphatic filariasis (LF) is a neglected tropical disease affecting an estimated 882.5 million people at risk of infection. It is caused by the filarial nematodes <jats:italic>Wuchereria bancrofti<\/jats:italic>, <jats:italic>Brugia malayi<\/jats:italic>, and <jats:italic>Brugia timori<\/jats:italic>, leading to lymphedema, and severe deformation of extremities and resulting in both physical and mental health consequences. Affected individuals often suffer from depression, anxiety, and anger, exacerbated by disability, marginalization, and societal rejection due to their physical disability.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A systematic review of the literature was conducted following the PRISMA guidelines, using the PubMed, Scopus, and Scielo databases without date restrictions, and including articles in both Spanish and English. The quality of selected articles was evaluated using the Newcastle-Ottawa Quality Assessment Scale and the JBI critical appraisal checklist. Our protocol was registered in PROSPERO under de code: CRD42024537760.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 23 studies were included in this analysis, which identified the emotional impact of LF. Common symptoms include depression, anxiety, frustration, anger, and feelings of inferiority. Physical disability caused by lymphedema led to societal rejection, contributing to the development of these symptoms. We also found that the severity or advancement of the disease correlated with an increased emotional and social impact.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>LF significantly impacts the quality of life due to both its physical and emotional consequences. Psychological support for affected individuals is crucial from diagnosis, and the education of transmission and treatment of LF in endemic communities is essential to prevent discrimination and exclusion.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pntd.0013073","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T17:45:42Z","timestamp":1746726342000},"page":"e0013073","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["The psychosocial and emotional burden of lymphatic filariasis: A systematic review"],"prefix":"10.1371","volume":"19","author":[{"given":"Jorge","family":"Vasconez-Gonzalez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Mi\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda de Lourdes","family":"Noboa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Tello-De-la-Torre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan S.","family":"Izquierdo-Condoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1895-7498","authenticated-orcid":true,"given":"Esteban","family":"Ortiz-Prado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"pntd.0013073.ref001","volume-title":"Lymphatic filariasis: a handbook of practical entomology for national lymphatic filariasis elimination programmes","author":"World Health Organization","year":"2013"},{"key":"pntd.0013073.ref002","unstructured":"WHO. 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