{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:48:10Z","timestamp":1782168490861,"version":"3.54.5"},"reference-count":22,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FDN- 148439"],"award-info":[{"award-number":["FDN- 148439"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004460","name":"Rotary Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004460","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012285","name":"BC Children's Hospital","doi-asserted-by":"publisher","award":["F24-01744"],"award-info":[{"award-number":["F24-01744"]}],"id":[{"id":"10.13039\/100012285","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec015\">\n<jats:title>Background<\/jats:title>\n<jats:p>Triggering receptor expressed on myeloid cells 1 (TREM1) is a cell-surface receptor expressed on neutrophils that amplifies the inflammatory response. Dengue virus (DENV) infection is characterized by systemic inflammation, endothelial activation, and vascular leakage.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec016\">\n<jats:title>Methodology\/Principal Findings<\/jats:title>\n<jats:p>We investigated circulating soluble TREM-1 (sTREM-1) levels in 244 children and young adults aged 1\u201326 years with dengue fever presenting to an outpatient clinic in the Philippines. Elevated sTREM-1 (\u2265130 pg\/mL) was associated with hemoconcentration, a hallmark of vascular leakage (odds ratio (OR) 3.8, 95%CI 1.6-10, p\u2009=\u20090.0020). In turn, hemoconcentration was associated with hospitalization (OR 4.2, 95%CI 1.0-38, p\u2009=\u20090.0497) and higher volume of intravenous fluid required for resuscitation (p\u2009=\u20090.019). Elevated inflammation marker TNF (\u22655 pg\/mL) was associated with increased sTREM-1 levels (p\u2009=\u20090.0014). Endothelial activation markers angiopoietin-2 (Ang-2), soluble FMS-like tyrosine kinase-1 (sFlt-1), and soluble vascular cell adhesion molecule 1 (sVCAM-1) were correlated with sTREM-1 levels (p\u2009&lt;\u20090.0001 for all three comparisons).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec017\">\n<jats:title>Conclusions\/significance<\/jats:title>\n<jats:p>Our findings suggest that sTREM-1 may be a clinically informative marker of neutrophil activation, associated with hemoconcentration, systemic inflammation, and endothelial activation and in dengue fever.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pntd.0013084","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T17:26:25Z","timestamp":1748885185000},"page":"e0013084","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Soluble triggering receptor expressed on myeloid cells 1 is associated with hemoconcentration and endothelial activation in children and young adults with dengue virus infection in the Philippines"],"prefix":"10.1371","volume":"19","author":[{"given":"Jiayi","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hridesh","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Ngai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Salome Siose","family":"Painaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James 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Tsheten","year":"2021","journal-title":"Infect Dis Poverty"},{"key":"pntd.0013084.ref006","first-page":"141","article-title":"Prothrombin time and partial thromboplastin time as a predictor of bleeding in patients with dengue hemorrhagic fever","author":"MN Chua","year":"1993","journal-title":"Southeast Asian J Trop Med Public Health"},{"issue":"11","key":"pntd.0013084.ref007","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1093\/infdis\/jiac383","article-title":"Association of neutrophil mediators with dengue disease severity and cardiac impairment in adults","volume":"226","author":"PY Chia","year":"2022","journal-title":"J Infect Dis"},{"key":"pntd.0013084.ref008","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.3389\/fimmu.2018.03007","article-title":"Neutrophil Activation and Early Features of NET Formation Are Associated With Dengue Virus Infection in Human","volume":"9","author":"A Opasawatchai","year":"2018","journal-title":"Front 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