{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:57:09Z","timestamp":1787021829289,"version":"build-2736575974"},"update-to":[{"DOI":"10.1371\/journal.pntd.0013240","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000}}],"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec016\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Using spatial analysis techniques, this study investigates the associations between socioeconomic indicators measured at the census tract level and the incidence of Zika virus (ZIKV) infection in pregnant persons and microcephaly in newborns in Recife, Pernambuco, Brazil, from 2015 to 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec017\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this ecological study, data on cases of ZIKV infections among pregnant persons registered in the Brazilian Information System for Notifiable Diseases (\n                      <jats:italic>Sistema de Informa\u00e7\u00e3o de Agravos de Notifica\u00e7ao<\/jats:italic>\n                      , SINAN-Zika) and cases of microcephaly among live births registered in the Public Health Event Registration System (\n                      <jats:italic>Registro de Eventos em Sa\u00fade P\u00fablica,<\/jats:italic>\n                      RESP-Microcefalia) and the Live Birth Information System (\n                      <jats:italic>Sistema de Informa\u00e7\u00f5es Sobre Nascidos Vivos,<\/jats:italic>\n                      SINASC) were georeferenced based on residential address and aggregated within census tracts. Spatial autocorrelation was performed using the bivariate global and local Moran\u2019s I indices, which considered the incidence rates of maternal ZIKV infections and microcephaly during the epidemic (2015\u20132017) and post-epidemic (2018\u20132021) time periods in relation to each other as well as social, economic, sanitation, and urban infrastructure covariates derived from the 2010 census.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec018\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 2015 to 2021, the city of Recife registered 253 cases (n\u2009=\u2009240 in 2015\u20132017 and n\u2009=\u200913 in 2018\u20132021) of ZIKV infection in pregnant persons and 147 cases (n\u2009=\u2009137 in 2015\u20132017 and n\u2009=\u200910 in 2018\u20132021) of microcephaly in newborns. The global bivariate Moran\u2019s I index between the incidences of ZIKV infection in pregnant persons and microcephaly were 0.127 (p\u2009=\u20090.001) in 2015\u20132017 and 0.074 (p\u2009=\u20090.002) in 2018\u20132021, indicating a positive spatial correlation, as higher was the ZIKV infection in pregnant persons, higher was the incidence of microcephaly. Furthermore, incidences of maternal ZIKV infection and microcephaly were consistently associated with indicators of greater social vulnerability and economic deprivation at the census tract level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec019\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>During the epidemic and post-epidemic periods in Recife, cases of ZIKV in pregnant persons and microcephaly were concentrated in census tracts with relatively higher socioeconomic vulnerability, reinforcing the need for research to inform the development of social protection and environmental policies to mitigate ZIKV-related risks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0013240","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T17:51:15Z","timestamp":1752083475000},"page":"e0013240","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mapping the risk of Zika virus infections in pregnant persons and microcephaly in newborns in relation to socioeconomic indicators in Recife, Pernambuco, Brazil: A spatial analysis (2015 to 2021)"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9181-344X","authenticated-orcid":true,"given":"Ana Carolyne de Carvalho","family":"Lucena S\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Luiz S\u00e1 de","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dem\u00f3crito de 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