{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:25:14Z","timestamp":1787235914245,"version":"build-2736575974"},"reference-count":104,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472305"],"award-info":[{"award-number":["82472305"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004335","name":"Southwest University of Science and Technology","doi-asserted-by":"publisher","award":["SWU-KR24012\/5330501123"],"award-info":[{"award-number":["SWU-KR24012\/5330501123"]}],"id":[{"id":"10.13039\/501100004335","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>\n                    The emerging fungal pathogen,\n                    <jats:italic>Cryptococcus gattii<\/jats:italic>\n                    , causes infections in both immunocompromised and immunocompetent individuals, often resulting in high mortality rates. While\n                    <jats:italic>Cryptococcus neoformans<\/jats:italic>\n                    is predominantly associated with cryptococcosis in immunocompromised patients, the significance of\n                    <jats:italic>C. gattii<\/jats:italic>\n                    infections has garnered attention due to its prevalence among seemingly healthy individuals. Notably,\n                    <jats:italic>C. gattii<\/jats:italic>\n                    exhibits distinct epidemiological patterns, geographic distribution, genotypes, and phenotypes compared to\n                    <jats:italic>C. neoformans<\/jats:italic>\n                    . However, the comprehension of\n                    <jats:italic>C. gattii<\/jats:italic>\n                    \u2019s virulence characteristics, regulatory mechanisms, and therapeutic avenues has lagged behind those of\n                    <jats:italic>C. neoformans<\/jats:italic>\n                    . The less robust clinical and epidemiological data, coupled with the limitations of effective treatment options, underscore the urgency in addressing\n                    <jats:italic>C. gattii<\/jats:italic>\n                    as a serious public health threat. In this review, I discuss the epidemiology, virulence factors, regulatory mechanisms, immunomodulatory attributes, and drug susceptibility of\n                    <jats:italic>C. gattii<\/jats:italic>\n                    . This comprehensive discussion aims to enhance our understanding of this emerging fungal pathogen and potentially contribute to the development of more effective prevention and management strategies.\n                  <\/jats:p>","DOI":"10.1371\/journal.pntd.0013245","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T13:43:43Z","timestamp":1751550223000},"page":"e0013245","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["The emerging fungal pathogen Cryptococcus gattii: Epidemiology, pathogenesis, immunomodulatory attributes, and drug 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