{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:29:13Z","timestamp":1790123353155,"version":"4.0.1"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008679","name":"Universidad de C\u00f3rdoba","doi-asserted-by":"publisher","award":["FCS 01 23"],"award-info":[{"award-number":["FCS 01 23"]}],"id":[{"id":"10.13039\/501100008679","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>\n                    <jats:italic>Plasmodium vivax<\/jats:italic>\n                    is the most widely distributed human protozoan in the world. It is a causative agent of malaria, with thrombocytopenia being a frequent complication. This study aimed to evaluate the effect of\n                    <jats:italic>P. vivax<\/jats:italic>\n                    infection on plasma cytokine\/chemokine levels and anti-phosphatidylserine (anti-PS) autoantibodies, to explore their potential role in thrombocytopenia during\n                    <jats:italic>P. vivax<\/jats:italic>\n                    malaria in C\u00f3rdoba, Colombia. We included patients with\n                    <jats:italic>P. vivax<\/jats:italic>\n                    malaria and thrombocytopenia (MT); patients with malaria without thrombocytopenia (M) and healthy controls (HC). Plasma cytokines\/chemokines (IL-2, IL-4, IL-1\u03b2, TNF-\u03b1, IL-17A, IL-6, IL-10, IFN\u03b3, IL-12p70, TGF-\u03b21\/IP-10, MCP-1, IL-8) were quantified. Evaluation of autoantibodies was performed by ELISA, using phosphatidylserine (PS) as the antigen. IFN\u03b3, IL-6, and IL-10 were found to increase in the MT group (P\u2009&lt;\u20090.05), whereas TGF-\u03b21 was increased in the M group (P\u2009&lt;\u20090.0001). Anti-PS antibody levels were also higher in the MT group and showed a negative correlation with platelet counts. These findings suggest that thrombocytopenia in\n                    <jats:italic>P. vivax<\/jats:italic>\n                    malaria may result from autoantibodies targeting phosphatidylserine on activated platelets, driven by a pro-inflammatory cytokine imbalance, with TGF-\u03b21 potentially exerting a protective effect.\n                  <\/jats:p>","DOI":"10.1371\/journal.pntd.0013284","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T17:24:01Z","timestamp":1753118641000},"page":"e0013284","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Thrombocytopenia in patients with Plasmodium vivax in Colombia is associated with anti-phosphatidylserine autoantibodies and IL-6, IFN\u03b3, IL-10 and TGF-\u03b2"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4278-8724","authenticated-orcid":true,"given":"Mar\u00eda Camila","family":"Velasco-Pareja","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Tovar-Acero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam E.","family":"Cantero Guevara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Rivera-Correa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Fernanda","family":"Yasnot-Acosta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"issue":"9918","key":"pntd.0013284.ref001","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0140-6736(13)60024-0","article-title":"Malaria","volume":"383","author":"NJ White","year":"2014","journal-title":"Lancet"},{"issue":"10130","key":"pntd.0013284.ref002","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/S0140-6736(18)30324-6","article-title":"Malaria","volume":"391","author":"EA Ashley","year":"2018","journal-title":"Lancet"},{"key":"pntd.0013284.ref003","unstructured":"World malaria report 2024. 2025."},{"issue":"3","key":"pntd.0013284.ref004","doi-asserted-by":"crossref","first-page":"180","DOI":"10.4103\/2230-8229.163040","article-title":"Complicated vivax malaria, an often underestimated condition - Case Report","volume":"22","author":"A Aashish","year":"2015","journal-title":"J Family Community Med"},{"key":"pntd.0013284.ref005","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1475-2875-11-12","article-title":"Understanding the clinical spectrum of complicated Plasmodium vivax malaria: a systematic review on the contributions of the Brazilian literature","volume":"11","author":"MVG Lacerda","year":"2012","journal-title":"Malar J"},{"key":"pntd.0013284.ref006","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1590\/S0074-02762011000900007","article-title":"Thrombocytopenia in malaria: who cares?","author":"MVG Lacerda","year":"2011","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"pntd.0013284.ref007","doi-asserted-by":"crossref","first-page":"5585272","DOI":"10.1155\/2021\/5585272","article-title":"Thrombocytopenia as a Diagnostic Marker for Malaria in Patients with Acute Febrile Illness","volume":"2021","author":"A Gebreweld","year":"2021","journal-title":"J Trop Med"},{"key":"pntd.0013284.ref008","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12936-016-1150-8","article-title":"Imported Plasmodium vivax malaria with severe thrombocytopaenia: can it be severe malaria or not?","volume":"15","author":"S Antinori","year":"2016","journal-title":"Malar J"},{"key":"pntd.0013284.ref009","doi-asserted-by":"crossref","DOI":"10.4103\/jcsr.jcsr_9_23","article-title":"Thrombocytopenia in malaria and its diagnostic significance: A prospective study","volume":"12","author":"P Krishna","year":"2023","journal-title":"Journal of Clinical and Scientific Research"},{"key":"pntd.0013284.ref010","unstructured":"INS. 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