{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T11:31:41Z","timestamp":1767180701666,"version":"build-2238731810"},"update-to":[{"DOI":"10.1371\/journal.pntd.0013301","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000}}],"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001704","name":"European Society of Clinical Microbiology and Infectious Diseases","doi-asserted-by":"publisher","award":["Research Grant Agreeement 2023"],"award-info":[{"award-number":["Research Grant Agreeement 2023"]}],"id":[{"id":"10.13039\/501100001704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["Ricerca Corrente - L2"],"award-info":[{"award-number":["Ricerca Corrente - L2"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cystic echinococcosis (CE) is a public health problem in livestock-breeding areas, including Chile, which adhered to the Pan American Health Organization Regional Program for the Elimination of CE 2020\u20132029. Abdominal ultrasound (US) screening of school-aged children (SAC) in high-risk areas is envisaged by the Action Plan for Control, Monitoring and Prevention of CE of the Ministry of Health (MoH) of Chile. We implemented pilot US screening and estimated CE prevalence in SAC in three municipalities prioritized by the MoH, to inform about the feasibility of targeting this age group within the activities of the Action Plan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methodology\/Principal findings<\/jats:title>\n                    <jats:p>A cross-sectional US screening was carried out in SAC (6\u201314 years) in R\u00edo Hurtado (Coquimbo region), Paillaco (Los R\u00edos), and Chile Chico (Ays\u00e9n) municipalities. CE was diagnosed according to the WHO-IWGE recommendations. A total of 873 SAC were screened over 10 working days, with excellent participation (81\u201393%). Three children had hepatic CE cysts (3\/873; 0.3%); the highest prevalence was found in Chile Chico (0.6%, 95% CI 0.2%-2.2%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Conclusions\/Significance<\/jats:title>\n                    <jats:p>US screening in SAC is technically feasible in Chile. While prevalence of CE in SAC might be too low to allow school-based monitoring and evaluation of a structured control program, US screening in SAC could allow early case-finding and support the implementation of control measures around new diagnoses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0013301","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T17:39:06Z","timestamp":1753119546000},"page":"e0013301","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasound screening for cystic echinococcosis of school-age children in endemic areas of Chile: A pilot cross-sectional study towards integration in the Regional Program for the Elimination of Cystic Echinococcosis 2020\u20132029"],"prefix":"10.1371","volume":"19","author":[{"given":"Cristian A.","family":"Alvarez Rojas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Manciulli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0478-3914","authenticated-orcid":true,"given":"Francesca","family":"Tamarozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Spinicci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"pntd.0013301.ref001","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/bs.apar.2016.11.002","article-title":"Ecology and life cycle patterns of Echinococcus species","volume":"95","author":"T Romig","year":"2017","journal-title":"Adv Parasitol"},{"key":"pntd.0013301.ref002","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/bs.apar.2016.09.006","article-title":"The echinococcoses: diagnosis, clinical management and burden of disease","volume":"96","author":"P Kern","year":"2017","journal-title":"Adv Parasitol"},{"issue":"1","key":"pntd.0013301.ref003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actatropica.2009.11.001","article-title":"Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans","volume":"114","author":"E Brunetti","year":"2010","journal-title":"Acta Trop"},{"key":"pntd.0013301.ref004","unstructured":"[cited 2025 Apr 4]. 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Available from: https:\/\/www.woah.org\/en\/what-we-do\/standards\/codes-and-manuals\/terrestrial-code-online-access\/"},{"key":"pntd.0013301.ref008","volume-title":"WHO\/OIE manual on echinococcosis in humans and animals: a public health problem of global concern","author":"World Organisation for Animal Health (Office International des Epizooties), World Health Organization, 2001","year":"2021"},{"key":"pntd.0013301.ref009","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/bs.apar.2016.11.001","article-title":"Global distribution of alveolar and cystic echinococcosis","volume":"95","author":"P Deplazes","year":"2017","journal-title":"Adv Parasitol"},{"key":"pntd.0013301.ref010","unstructured":"Organizacion Panamericana de Salud. 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