{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T15:08:38Z","timestamp":1771859318577,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pntd.0013409","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000}}],"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00c3fico e Tecnol\u00c3\u00b3gico","doi-asserted-by":"publisher","award":["465489\/2014-1"],"award-info":[{"award-number":["465489\/2014-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018908","name":"Funda\u00c3\u00a7\u00c3\u00a3o Nacional de Desenvolvimento do Ensino Superior Particular","doi-asserted-by":"publisher","award":["9600140"],"award-info":[{"award-number":["9600140"]}],"id":[{"id":"10.13039\/501100018908","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00c3fico e Tecnol\u00c3\u00b3gico","doi-asserted-by":"publisher","award":["308167\/2021-0"],"award-info":[{"award-number":["308167\/2021-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018908","name":"Funda\u00c3\u00a7\u00c3\u00a3o Nacional de Desenvolvimento do Ensino Superior Particular","doi-asserted-by":"publisher","award":["9600141"],"award-info":[{"award-number":["9600141"]}],"id":[{"id":"10.13039\/501100018908","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00c3fico e Tecnol\u00c3\u00b3gico","doi-asserted-by":"publisher","award":["473667\/2012-6"],"award-info":[{"award-number":["473667\/2012-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Human T-cell leukemia virus type 1 (HTLV-1) causes inflammatory diseases and is associated with various muscle abnormalities, including polymyositis. Elevated serum creatine kinase (CPK) levels are typically indicative of muscle damage.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Aims<\/jats:title>\n<jats:p>This study aimed to determine the prevalence of HTLV-1 associated inflammatory myopathies (HAIM) in a large cohort of People living with HTLV-1 from Salvador, Brazil. Additionally, we sought to describe the clinical, laboratory, and histopathological findings of seven HTLV-1-infected patients with persistent hyperCKemia.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Methods<\/jats:title>\n<jats:p>This study included 503 HTLV-1-infected patients from a cohort in Salvador, Brazil, who were analyzed for creatine phosphokinase (CPK) levels. Clinical, laboratory, and pathologic examinations were performed in patients whose CPK levels were above the upper limit of the normal range in the two tests performed at different time points.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Results<\/jats:title>\n<jats:p>Polymyositis was the main cause of HAIM in the study population, with a prevalence rate of 0.6%. Two cases were diagnosed with muscular dystrophy and mitochondrial disease, and in two other patients the cause of hyperCKemia could not be determined and is currently under investigation.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Polymyositis was the main cause of HAIM in this cfohort of People living with HTLV-1.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pntd.0013409","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T17:47:14Z","timestamp":1755712034000},"page":"e0013409","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence of human T-cell leukemia virus type 1 associated inflammatory myopathies (HAIM) in Salvador, Brazil"],"prefix":"10.1371","volume":"19","author":[{"given":"Adriele Ribeiro 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