{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:01:54Z","timestamp":1792425714127,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0013470","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000}}],"reference-count":76,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["428107"],"award-info":[{"award-number":["428107"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dengue, chikungunya, and Zika present significant public health challenges in Colombia. Spatial studies help clarify the distribution and progression of these diseases over time and location. Objective to describe the spatio-temporal distribution and clustering patterns of dengue, chikungunya, and Zika in Medell\u00edn, Colombia, between 2013 and 2021, with the aim of providing baseline spatial intelligence to support future epidemiological and policy-oriented analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed dengue, chikungunya, and Zika cases in Medell\u00edn from 2013 to 2021, using weekly data from 27,459 geocoded cases across 265 neighborhoods. Cases were geocoded by neighborhood based on residential addresses in the national surveillance system (SIVIGILA). Spatio-temporal analysis identified high-risk clusters and examined the co-circulation of the diseases through multivariate analysis. We used scan statistics with a discrete Poisson model to detect high-risk clusters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 2013 to 2021, 26,350 dengue cases probable and confirmed were reported, with an annual incidence of 137.3 per 100,000 residents. Chikungunya and Zika emerged in 2014 and 2015, with 574 and 515 cases reported, resulting in incidences of 5.1 and 3.8 per 100,000 residents, respectively. We identified five dengue clusters and four clusters each for Zika and chikungunya, mainly in Medell\u00edn\u2019s northeast. Multivariate analysis revealed six clusters, with four exhibiting high risk for all three diseases. Co-circulation of dengue, chikungunya, and Zika occurred between September 2015 and February 2017. Dengue clusters peaked between 2015 and 2016, while chikungunya and Zika peaks occurred in 2015 and 2016, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study advances understanding of spatio-temporal dynamics in arbovirus transmission in Medell\u00edn, highlighting high-risk clusters for dengue, chikungunya, and Zika and their collective presence. Our findings support targeted public health interventions to mitigate these diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0013470","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T17:46:38Z","timestamp":1757094398000},"page":"e0013470","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Spatio-temporal analysis of the distribution and co-circulation of dengue, chikungunya, and Zika in Medell\u00edn, Colombia, from 2013 to 2021"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7666-9099","authenticated-orcid":true,"given":"Jorge E.","family":"Salazar Fl\u00f3rez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berta N.","family":"Restrepo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"La\u00eds Picinini","family":"Freitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mabel","family":"Carabali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria I.","family":"Jaramillo Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar Garcia","family":"Balaguera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brayan S. 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