{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:45:46Z","timestamp":1793115946109,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0013530","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000}}],"reference-count":19,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020044","name":"Yale School of Public Health, Yale University","doi-asserted-by":"publisher","award":["CR3028043"],"award-info":[{"award-number":["CR3028043"]}],"id":[{"id":"10.13039\/100020044","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>Dengue, a mosquito-borne tropical disease caused by the dengue virus, has seen a significant increase in global incidence in recent decades. China has experienced a rapid rise in dengue cases since 2013, posing a serious threat to population health and increasing economic burden. This study aimed to evaluate the knowledge of, and attitudes toward, dengue fever and dengue vaccination among healthcare practitioners in China. A cross-sectional study was conducted using an online questionnaire survey targeting medical professionals in Zhejiang, Yunnan, and Hainan provinces, which are endemic areas for dengue virus infection in China. The questionnaire assessed participants\u2019 understanding of dengue virus transmission, high-risk groups, symptoms, and knowledge of and attitudes toward dengue vaccines. Results showed that 98.6% of participants reported having prior knowledge of dengue virus. Knowledge of at-risk populations was strongly associated with actual dengue knowledge and vaccine attitudes, which may drive vaccine acceptance. Most respondents (71.0%) held neutral attitudes toward dengue vaccination, followed by 20.8% who held positive attitudes and 8.2% who held negative attitudes. Individuals with neutral attitudes were the most critical in determining vaccine acceptance. Among those who accepted vaccination, 56.1% held neutral attitudes, and among those who refused vaccination, 84.3% held neutral attitudes. Whilst most respondents (87.6%) reported that they would vaccinate susceptible populations against dengue, only 7.5% were aware that approved dengue vaccines exist. This study provides valuable insights into current knowledge of, and attitudes toward, dengue fever and vaccination among healthcare practitioners in China. Associations between specific knowledge domains, vaccine attitudes, and vaccine acceptance highlight directions for educational campaigns and vaccine promotion.<\/jats:p>","DOI":"10.1371\/journal.pntd.0013530","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T17:38:33Z","timestamp":1785951513000},"page":"e0013530","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating knowledge and attitudes towards dengue fever and its vaccination in China: A questionnaire-based study in healthcare practitioners"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6001-4247","authenticated-orcid":true,"given":"IpMan","family":"Lam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4651-9433","authenticated-orcid":true,"given":"Yihan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"issue":"10","key":"pntd.0013530.ref001","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1139\/cjm-2020-0572","article-title":"Dengue virus: epidemiology, biology, and disease aetiology","volume":"67","author":"SK Roy","year":"2021","journal-title":"Can J Microbiol"},{"issue":"2","key":"pntd.0013530.ref002","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jcv.2007.04.006","article-title":"The differences of clinical manifestations and laboratory findings in children and adults with dengue virus infection","volume":"39","author":"L Kittigul","year":"2007","journal-title":"Journal of Clinical Virology"},{"key":"pntd.0013530.ref003","doi-asserted-by":"crossref","first-page":"107940","DOI":"10.1016\/j.ijid.2025.107940","article-title":"Global dengue epidemic worsens with record 14 million cases and 9000 deaths reported in 2024","volume":"158","author":"N Haider","year":"2025","journal-title":"International Journal of Infectious Diseases"},{"issue":"3","key":"pntd.0013530.ref004","article-title":"Understanding antibody-dependent enhancement in dengue: Are afucosylated IgG1s a concern?","volume":"19","author":"A Teo","year":"2023","journal-title":"PLoS Pathog"},{"issue":"1","key":"pntd.0013530.ref005","article-title":"Dengue fever and dengue virus in the People\u2019s Republic of China","volume":"32","author":"T Wu","year":"2022","journal-title":"Reviews in Medical Virology"},{"key":"pntd.0013530.ref006","unstructured":"Overview of the national notifiable infectious disease epidemic in 2016. 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Centers for Disease Control and Prevention. https:\/\/www.cdc.gov\/dengue\/vaccine\/parents\/eligibility.html Accessed 2023 October 13."},{"issue":"1","key":"pntd.0013530.ref013","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41541-023-00658-2","article-title":"Is new dengue vaccine efficacy data a relief or cause for concern?","volume":"8","author":"SJ Thomas","year":"2023","journal-title":"NPJ Vaccines"},{"issue":"21","key":"pntd.0013530.ref014","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1056\/NEJMoa1903869","article-title":"Efficacy of a Tetravalent Dengue Vaccine in Healthy Children and Adolescents","volume":"381","author":"S Biswal","year":"2019","journal-title":"N Engl J Med"},{"key":"pntd.0013530.ref015","unstructured":"Centers for Disease Control and Prevention. 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