{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:13:47Z","timestamp":1793088827991,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0013571","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000}}],"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["226474\/Z\/22\/Z"],"award-info":[{"award-number":["226474\/Z\/22\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>The Mekong Delta Region (MDR) of Vietnam faces increasing vulnerability to severe dengue outbreaks due to urbanization, globalization, and climate change, necessitating effective early warning systems for outbreak mitigation. This study developed a probabilistic forecasting model to predict dengue incidence and outbreaks with 1\u20133-month lead times, incorporating meteorological,\u00a0sociodemographic, preventive, and epidemiological data. A total of 72 models were evaluated, with top performers from spatiotemporal models, supervised PCA, and semi-mechanistic hhh4 frameworks combined into an ensemble. Using data from 2004-2011 for development, 2012\u20132016 for cross-validation, and 2017\u20132022 for evaluation, the ensemble model integrated five individual models to forecast dengue incidence up to three months ahead. Performance was assessed using Brier Score, Continuous Ranked Probability Score, bias, and diffuseness, and we evaluated performance by horizon, geography, and seasonality. Using the 95th percentile of the historical distribution as the epidemic threshold, the ensemble model achieved 69% accuracy at a 3-month horizon during evaluation, surpassing the reference model\u2019s 58%, though it struggled in years with atypical seasonality, such as 2019 and 2022, possibly due to COVID-19 disruptions. By providing critical lead time, the model enables health systems to allocate resources, plan interventions, and engage communities in dengue prevention and control.<\/jats:p>","DOI":"10.1371\/journal.pntd.0013571","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T22:01:48Z","timestamp":1759183308000},"page":"e0013571","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["A district-level ensemble model to enhance dengue prediction and control for the Mekong Delta Region of Vietnam"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9681-1278","authenticated-orcid":true,"given":"Wala","family":"Draidi Areed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Thanh Thao","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kien","family":"Quoc Do","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thinh","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinh","family":"Bui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua L.","family":"Warren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quang-Van","family":"Doan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam Vu","family":"Sinh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas John","family":"Osborne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Richards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nu Quy Linh","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuan","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trinh Manh","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Son","family":"Nghiem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Phung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cordia","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Dubrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Weinberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dung","family":"Phung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"pntd.0013571.ref001","doi-asserted-by":"crossref","unstructured":"Haider N, Hasan MN, Onyango J, Asaduzzaman M. 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