{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T06:58:11Z","timestamp":1778137091294,"version":"3.51.4"},"update-to":[{"DOI":"10.1371\/journal.pntd.0013620","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000}}],"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Leptospirosis is a re-emerging zoonotic disease. In French Guiana (FG), updating its epidemiology is essential to guide prevention strategies. This study aimed to describe human leptospirosis cases from 2016 to 2022 and compare them to the cases from 2007 to 2014 (using similar diagnostic criteria).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methodology\/Principal findings<\/jats:title>\n                    <jats:p>A multicentric cross-sectional study was conducted in the three hospitals of FG and the remote health centers. Cases were identified via biological diagnostics, defined by a compatible clinical picture and a positive biological test and classified according to the test as confirmed (positive PCR or Microscopic agglutination test [MAT] \u2265400) or probable (MAT\u2009=\u2009200 or positive IgM only without alternate diagnosis). Severe cases involved renal, circulatory, or respiratory failure, or death. A total of 188 cases were included, of which 138 (73.4%) were confirmed. Median (IQR) age was 38 (28\u201352) years, with a male-to-female ratio of 3.1. Twenty-six (13.8%) cases were severe, including 4 deaths (2.1%). Most patients had multiple exposure factors with rodent exposure being the most common; 67.5% (available data) had both domestic and non-domestic exposures. Notably, over a third of patients were in a situation of precarity, uninsured or lived in informal settlements. The mean (SD) annual number of cases increased from 5.8 (2.7) per 100,000 of the adult population in the 2007\u20132014 period to 14.0 (9.2) in the recent study period (p\u2009=\u20090.03). Early clinical suspicion improved, while the proportion of severe cases remained stable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Discussion\/Conclusion<\/jats:title>\n                    <jats:p>Leptospirosis is an increasing public health issue in FG which particularly affects socioeconomically vulnerable populations. Routes of transmission appear multiple.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0013620","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T17:35:52Z","timestamp":1760376952000},"page":"e0013620","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evolution of human leptospirosis in French Guiana, 2016\u20132022"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7602-7872","authenticated-orcid":true,"given":"Mathilde","family":"Zenou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascale","family":"Bourhy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Abboud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"Saout","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e9lix","family":"Djossou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Michaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ars\u00e8ne","family":"Kpangon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Fremery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Higel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Fran\u00e7ois","family":"Carod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christelle","family":"Prince","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Trombert-Paolantoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexia","family":"Barbry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Nacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Picardeau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lo\u00efc","family":"Epelboin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6164-311X","authenticated-orcid":true,"given":"Paul","family":"Le Turnier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"issue":"9","key":"pntd.0013620.ref001","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003898","article-title":"Global morbidity and mortality of leptospirosis: a systematic review","volume":"9","author":"F Costa","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"10","key":"pntd.0013620.ref002","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004122","article-title":"Global burden of leptospirosis: estimated in terms of disability adjusted life years","volume":"9","author":"PR Torgerson","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"3","key":"pntd.0013620.ref003","doi-asserted-by":"crossref","first-page":"590","DOI":"10.4269\/ajtmh.17-0734","article-title":"Epidemiology of human Leptospirosis in French Guiana (2007-2014): a retrospective study","volume":"99","author":"P Le Turnier","year":"2018","journal-title":"Am J Trop Med Hyg"},{"issue":"3","key":"pntd.0013620.ref004","first-page":"165","article-title":"Leptospirosis in French Guiana and the Guiana shield: current knowledge in 2016","volume":"110","author":"L Epelboin","year":"2017","journal-title":"Bull Soc Pathol Exot"},{"key":"pntd.0013620.ref005","unstructured":"Meteofrance annual reports. https:\/\/meteofrance.gf\/fr\/climat\/bulletins-annuels"},{"key":"pntd.0013620.ref006","doi-asserted-by":"crossref","first-page":"1364229","DOI":"10.3389\/fpubh.2024.1364229","article-title":"The role of health mediation in investigation of Hantavirus cases among informal settlements inhabitants of Cayenne area, French Guiana, 2022-2023","volume":"12","author":"M Oberlis","year":"2024","journal-title":"Front Public Health"},{"key":"pntd.0013620.ref007","unstructured":"Agence d\u2019Urbanisme et de D\u00e9veloppement de la Guyane (AUDeG). 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