{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:48:39Z","timestamp":1792788519774,"version":"4.5.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Livestock Vaccine Innovation Fund","award":["109273-001"],"award-info":[{"award-number":["109273-001"]}]},{"DOI":"10.13039\/100000865","name":"Bill & Melinda Gates Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008627","name":"Global Affairs Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008627","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Canada\u00e2\u20ac\u2122s International Development Research Centre"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>\n                    Cysticercosis in humans caused by the parasite\n                    <jats:italic>Taenia solium<\/jats:italic>\n                    is one of the World Health Organization\u2019s Neglected Tropical Diseases. The parasite is transmitted between the human host and pigs. Efforts to prevent the disease have relied mainly on treatment of people with anthelmintics. However, to date, there is no practical and effective control method that has been delivered as a public health program. Here we describe a large-scale, minimum inputs\n                    <jats:italic>T. solium<\/jats:italic>\n                    control program implemented as a public health program in Madagascar. Initially all pigs were vaccinated for porcine cysticercosis and medicated with oxfendazole, after which only young piglets and pigs imported into the program area were targeted for interventions. After piglet interventions were in place and on-going, a single mass drug administration (MDA) was delivered to the human population with a taeniacide. The outcomes were assessed one year after the human treatment, by comparing pre-and post-intervention levels of porcine cysticercosis caused by\n                    <jats:italic>T. solium<\/jats:italic>\n                    and human\n                    <jats:italic>T. solium<\/jats:italic>\n                    taeniasis. Over a twenty-two-month period, 96,735 pig vaccinations and oxfendazole medications were delivered and during the MDA, 117,216 people received taeniacide. Ninety percent of the pig population were receiving vaccination and medication at the end of the intervention period. Coverage of the eligible human population by the MDA was 62.5%. Prior to the intervention 30.8% of slaughter-age pigs had viable\n                    <jats:italic>T. solium<\/jats:italic>\n                    infection, reduced to 8% after the program. Human taeniasis was found to be 1.25% prior to the MDA and 0.6% one year after the MDA. The program successfully demonstrated effective control of\n                    <jats:italic>T. solium<\/jats:italic>\n                    transmission to pigs using minimum inputs and delivered as a public health program. Sustained control and expansion of the program could potentially lead to the elimination of the disease being a public health problem in Madagascar.\n                  <\/jats:p>","DOI":"10.1371\/journal.pntd.0013624","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T18:30:15Z","timestamp":1762367415000},"page":"e0013624","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of a One Health public health program based on minimum inputs to control Taenia solium in Madagascar"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4911-9312","authenticated-orcid":true,"given":"Diana 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