{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:31:30Z","timestamp":1791469890685,"version":"4.3.4"},"update-to":[{"DOI":"10.1371\/journal.pntd.0013632","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000}}],"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Yaws, a neglected tropical disease caused by\n                      <jats:italic>Treponema pallidum<\/jats:italic>\n                      subsp.\n                      <jats:italic>pertenue<\/jats:italic>\n                      remains a public health challenge in endemic regions. Although the World Health Organization (WHO) has earmarked yaws for eradication by the year 2030, there is a dearth of accurate epidemiological data to facilitate eradication efforts. The WHO recommends the use of seroprevalence surveys and geospatial analysis to guide planned interventions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methodology and findings<\/jats:title>\n                    <jats:p>We conducted a cross-sectional study in Wassa Amenfi East and Aowin districts in Ghana, clinically screening 11,505 school children for yaws. Treponemal Rapid Diagnostic Test (RDTs) detected 117 individuals, and the Dual Path Platform (DPP) confirmed 73 cases, giving an overall prevalence of 0.63%; and 3.85% for Aowin district compared to 0.31% for the Wassa Amenfi East district. Prevalence among RDT-tested was 7.79%, (34.54% from Aowin and 4.42% from Wassa Amenfi East) and DPP seroprevalence was 62.39% (Aowin, 70.69% and Wassa Amenfi East, 54.24%). A prevalence rate of 0.02% for latent infection was recorded in Wassa Amenfi East.<\/jats:p>\n                    <jats:p>Spatial analysis employing multiple mapping techniques including spatial autocorrelation analysis (Moran\u2019s I), kriging, nearest neighbour analysis, and kernel density estimation using data from the surveyed communities indicated significantly clustered hotspots in Aowin\u2019s central and Wassa Amenfi East\u2019s southeastern part. Kriging interpolation with barriers and Empirical Bayesian kriging revealed consistent spatial trends in unsurveyed communities in the study area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study found an overall yaws prevalence of 0.63% but with significantly clustered hotspots in some parts of the districts. The findings from this study highlight the importance of serosurveys and geospatial modeling in generating critical data to guide surveillance, education, and mass drug administration (MDA) efforts in endemic regions to support the WHO\u2019s goal of eradicating yaws by 2030.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0013632","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T17:44:00Z","timestamp":1760636640000},"page":"e0013632","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Seroprevalence and geospatial epidemiology of yaws: Evidence from Ghana"],"prefix":"10.1371","volume":"19","author":[{"given":"Abigail","family":"Agbanyo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Ntiamoah","family":"Oppong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth Dede","family":"Tuwor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadrach","family":"Mintah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Yaw","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clement","family":"Tettey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Azabire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owusu Boakye","family":"Yiadom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis Odai","family":"Laryea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Owusu-Ofori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4642-789X","authenticated-orcid":true,"given":"Yaw Ampem","family":"Amoako","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard Odame","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,10,16]]},"reference":[{"issue":"4","key":"pntd.0013632.ref001","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/aje\/kwx305","article-title":"Targeted Treatment of Yaws With Household Contact Tracing: How Much Do We Miss?","volume":"187","author":"L Dyson","year":"2018","journal-title":"Am J Epidemiol"},{"issue":"8","key":"pntd.0013632.ref002","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000275","article-title":"Yaws: a second (and maybe last?) chance for eradication","volume":"2","author":"A Rinaldi","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"issue":"10","key":"pntd.0013632.ref003","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005985","article-title":"The cost and cost-effectiveness of rapid testing strategies for yaws diagnosis and surveillance","volume":"11","author":"C Fitzpatrick","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0013632.ref004","unstructured":"WHO. 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