{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T21:16:04Z","timestamp":1769980564592,"version":"3.49.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0013646","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000}}],"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023QH318"],"award-info":[{"award-number":["ZR2023QH318"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ubei Provincial Natural Science Foundation Collaborative Fund Project","award":["2023AFD164"],"award-info":[{"award-number":["2023AFD164"]}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>\n                    Bats are recognized as hosts of diverse\n                    <jats:italic>\n                      <jats:italic>Bartonella<\/jats:italic>\n                    <\/jats:italic>\n                    species, and\n                    <jats:italic>\n                      <jats:italic>Bartonella<\/jats:italic>\n                    <\/jats:italic>\n                    are known agents of human disease. Here, we reported the isolation of 26\n                    <jats:italic>\n                      <jats:italic>Bartonella<\/jats:italic>\n                    <\/jats:italic>\n                    strains belonging to eight distinct species from two bat species (\n                    <jats:italic>\n                      <jats:italic>Myotis laniger<\/jats:italic>\n                    <\/jats:italic>\n                    and\n                    <jats:italic>\n                      <jats:italic>M. adversus<\/jats:italic>\n                    <\/jats:italic>\n                    ) and their ectoparasites (bat flies and bat mites) collected from Chongming County, Hubei Province, China. We obtained whole genome sequences of the bat-borne\n                    <jats:italic>\n                      <jats:italic>Bartonella<\/jats:italic>\n                    <\/jats:italic>\n                    spp. with second and third generation sequencing. The genome size of the bat-borne\n                    <jats:italic>\n                      <jats:italic>Bartonella<\/jats:italic>\n                    <\/jats:italic>\n                    spp. ranged from 1.39 to 1.98\u2009Mb, with the GC content from 35.30%-38.92%. Phylogenetic analysis revealed that the bat-borne\n                    <jats:italic>\n                      <jats:italic>Bartonella<\/jats:italic>\n                    <\/jats:italic>\n                    spp. were divergent from currently known\n                    <jats:italic>\n                      <jats:italic>Bartonella<\/jats:italic>\n                    <\/jats:italic>\n                    spp., and the Average Nucleotide Identity (ANI) values were all below 95%, indicating that they were all novel species. Comparative genomic analysis underscored distinct characteristics of bat-borne\n                    <jats:italic>\n                      <jats:italic>Bartonella<\/jats:italic>\n                    <\/jats:italic>\n                    spp. in cell motility, replication, recombination, and the biogenesis of the cell wall\/membrane\/envelope, suggesting that bat-borne\n                    <jats:italic>\n                      <jats:italic>Bartonella<\/jats:italic>\n                    <\/jats:italic>\n                    spp. exhibited unique host adaptability. Notably, the virulence factor genes of two bat-borne\n                    <jats:italic>\n                      <jats:italic>Bartonella<\/jats:italic>\n                    <\/jats:italic>\n                    spp., strains B23 and 39, were highly analogous to those of the currently known\n                    <jats:italic>\n                      <jats:italic>Bartonella henselae<\/jats:italic>\n                    <\/jats:italic>\n                    and\n                    <jats:italic>\n                      <jats:italic>Bartonella quintana<\/jats:italic>\n                    <\/jats:italic>\n                    , indicating that they might be pathogenic to humans and animals. Altogether, our findings significantly broaden the diversity of the\n                    <jats:italic>\n                      <jats:italic>Bartonella<\/jats:italic>\n                    <\/jats:italic>\n                    genus, and provide new insights into the host specificity and evolutionary relationship of bat-borne\n                    <jats:italic>\n                      <jats:italic>Bartonella<\/jats:italic>\n                    <\/jats:italic>\n                    spp..\n                  <\/jats:p>","DOI":"10.1371\/journal.pntd.0013646","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T17:44:15Z","timestamp":1761241455000},"page":"e0013646","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genomic characterization of eight novel Bartonella species from bats and ectoparasites reveals phylogenetic diversity and host adaptation"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9714-2708","authenticated-orcid":true,"given":"Wen-Jie","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing-Zhou","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Ju","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"issue":"2","key":"pntd.0013646.ref001","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1051\/vetres\/2009011","article-title":"Ecological fitness and strategies of adaptation of Bartonella species to their hosts and vectors","volume":"40","author":"BB Chomel","year":"2009","journal-title":"Vet Res"},{"issue":"4","key":"pntd.0013646.ref002","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1099\/00207713-43-4-777","article-title":"Proposals to unify the genera Bartonella and Rochalimaea, with descriptions of Bartonella quintana comb. nov., Bartonella vinsonii comb. nov., Bartonella henselae comb. nov., and Bartonella elizabethae comb. nov., and to remove the family Bartonellaceae from the order Rickettsiales","volume":"43","author":"DJ Brenner","year":"1993","journal-title":"Int J Syst Bacteriol"},{"issue":"8","key":"pntd.0013646.ref003","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1128\/jcm.33.8.2107-2113.1995","article-title":"Strategy to detect and identify Bartonella species in routine clinical laboratory yields Bartonella henselae from human immunodeficiency virus-positive patient and unique Bartonella strain from his cat","volume":"33","author":"JE Clarridge","year":"1995","journal-title":"J Clin Microbiol"},{"issue":"4","key":"pntd.0013646.ref004","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1128\/jcm.31.4.872-881.1993","article-title":"Rochalimaea elizabethae sp. nov. isolated from a patient with endocarditis","volume":"31","author":"JS Daly","year":"1993","journal-title":"J Clin Microbiol"},{"issue":"12","key":"pntd.0013646.ref005","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1128\/JCM.37.12.4034-4038.1999","article-title":"Demonstration of Bartonella grahamii DNA in ocular fluids of a patient with neuroretinitis","volume":"37","author":"FT Kerkhoff","year":"1999","journal-title":"J Clin Microbiol"},{"issue":"8","key":"pntd.0013646.ref006","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nrmicro1209","article-title":"Bartonella-host-cell interactions and vascular tumour formation","volume":"3","author":"C Dehio","year":"2005","journal-title":"Nat Rev Microbiol"},{"issue":"3","key":"pntd.0013646.ref007","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1099\/ijsem.0.003952","article-title":"Bartonella kosoyi sp. nov. and Bartonella krasnovii sp. nov., two novel species closely related to the zoonotic Bartonella elizabethae, isolated from black rats and wild desert rodent-fleas","volume":"70","author":"R Guti\u00e9rrez","year":"2020","journal-title":"Int J Syst Evol Microbiol"},{"key":"pntd.0013646.ref008","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1099\/ijs.0.041939-0","article-title":"Bartonella jaculi sp. nov., Bartonella callosciuri sp. nov., Bartonella pachyuromydis sp. nov. and Bartonella acomydis sp. nov., isolated from wild Rodentia","volume":"63","author":"S Sato","year":"2013","journal-title":"Int J Syst Evol Microbiol"},{"key":"pntd.0013646.ref009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virusres.2015.05.006","article-title":"Bats as reservoirs of severe emerging infectious diseases","volume":"205","author":"H-J Han","year":"2015","journal-title":"Virus Res"},{"key":"pntd.0013646.ref010","doi-asserted-by":"crossref","first-page":"104719","DOI":"10.1016\/j.meegid.2021.104719","article-title":"Bats are key hosts in the radiation of mammal-associated Bartonella bacteria","volume":"89","author":"CD McKee","year":"2021","journal-title":"Infect Genet Evol"},{"issue":"10","key":"pntd.0013646.ref011","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0012584","article-title":"Bat-associated ticks as a potential link for vector-borne pathogen transmission between bats and other animals","volume":"18","author":"T Szentiv\u00e1nyi","year":"2024","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"pntd.0013646.ref012","article-title":"Novel Bartonella species in insectivorous bats, Northern China","volume":"12","author":"H-J Han","year":"2017","journal-title":"PLoS One"},{"issue":"4","key":"pntd.0013646.ref013","article-title":"Bats and their ectoparasites (Nycteribiidae and Spinturnicidae) carry diverse novel Bartonella genotypes, China","volume":"69","author":"H-J Han","year":"2022","journal-title":"Transbound Emerg Dis"},{"issue":"1","key":"pntd.0013646.ref014","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1574-695X.2011.00908.x","article-title":"Role of the spleen in Bartonella spp. infection","volume":"64","author":"HK Deng","year":"2012","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"1","key":"pntd.0013646.ref015","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1038\/s41598-021-81508-w","article-title":"Genetic diversity of Bartonella species in small mammals in the Qaidam Basin, western China","volume":"11","author":"H Rao","year":"2021","journal-title":"Sci Rep"},{"issue":"3","key":"pntd.0013646.ref016","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1128\/JCM.01914-08","article-title":"Association of unique, isolated treponemes with bovine digital dermatitis lesions","volume":"47","author":"NJ Evans","year":"2009","journal-title":"J Clin Microbiol"},{"issue":"1","key":"pntd.0013646.ref017","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/molbev\/msu300","article-title":"IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies","volume":"32","author":"L-T Nguyen","year":"2015","journal-title":"Mol Biol Evol"},{"issue":"2","key":"pntd.0013646.ref018","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.107","article-title":"Ultrafast one-pass FASTQ data preprocessing, quality control, and deduplication using fastp","volume":"2","author":"S Chen","year":"2023","journal-title":"Imeta"},{"issue":"17","key":"pntd.0013646.ref019","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"S Chen","year":"2018","journal-title":"Bioinformatics"},{"issue":"1","key":"pntd.0013646.ref020","doi-asserted-by":"crossref","DOI":"10.1002\/cpbi.102","article-title":"Using SPAdes de novo assembler","volume":"70","author":"A Prjibelski","year":"2020","journal-title":"Curr Protoc Bioinformatics"},{"issue":"19","key":"pntd.0013646.ref021","doi-asserted-by":"crossref","first-page":"3210","DOI":"10.1093\/bioinformatics\/btv351","article-title":"BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs","volume":"31","author":"FA Sim\u00e3o","year":"2015","journal-title":"Bioinformatics"},{"issue":"7","key":"pntd.0013646.ref022","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1101\/gr.186072.114","article-title":"CheckM: assessing the quality of microbial genomes recovered from isolates, single cells, and metagenomes","volume":"25","author":"DH Parks","year":"2015","journal-title":"Genome Res"},{"issue":"14","key":"pntd.0013646.ref023","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1093\/bioinformatics\/btu153","article-title":"Prokka: rapid prokaryotic genome annotation","volume":"30","author":"T Seemann","year":"2014","journal-title":"Bioinformatics"},{"key":"pntd.0013646.ref024","article-title":"MAFFT-DASH: integrated protein sequence and structural alignment","volume":"47","author":"J Rozewicki","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"pntd.0013646.ref025","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/s13059-019-1832-y","article-title":"OrthoFinder: phylogenetic orthology inference for comparative genomics","volume":"20","author":"DM Emms","year":"2019","journal-title":"Genome Biol"},{"key":"pntd.0013646.ref026","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkae268","article-title":"Interactive Tree of Life (iTOL) v6: recent updates to the phylogenetic tree display and annotation tool","volume":"52","author":"I Letunic","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"pntd.0013646.ref027","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1099\/ijs.0.64483-0","article-title":"DNA-DNA hybridization values and their relationship to whole-genome sequence similarities","volume":"57","author":"J Goris","year":"2007","journal-title":"Int J Syst Evol Microbiol"},{"issue":"7","key":"pntd.0013646.ref028","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1099\/ijsem.0.002809","article-title":"Using average nucleotide identity to improve taxonomic assignments in prokaryotic genomes at the NCBI","volume":"68","author":"S Ciufo","year":"2018","journal-title":"Int J Syst Evol Microbiol"},{"key":"pntd.0013646.ref029","article-title":"TYGS and LPSN: a database tandem for fast and reliable genome-based classification and nomenclature of prokaryotes","volume":"50","author":"JP Meier-Kolthoff","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"pntd.0013646.ref030","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1471-2105-14-60","article-title":"Genome sequence-based species delimitation with confidence intervals and improved distance functions","volume":"14","author":"JP Meier-Kolthoff","year":"2013","journal-title":"BMC Bioinform"},{"key":"pntd.0013646.ref031","article-title":"Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation","volume":"44","author":"NA O\u2019Leary","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"pntd.0013646.ref032","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gky1085","article-title":"eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses","volume":"47","author":"J Huerta-Cepas","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"pntd.0013646.ref033","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/s41592-021-01101-x","article-title":"Sensitive protein alignments at tree-of-life scale using diamond","volume":"18","author":"B Buchfink","year":"2021","journal-title":"Nat Methods"},{"issue":"22","key":"pntd.0013646.ref034","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1093\/bioinformatics\/btv421","article-title":"Roary: rapid large-scale prokaryote pan genome analysis","volume":"31","author":"AJ Page","year":"2015","journal-title":"Bioinformatics"},{"key":"pntd.0013646.ref035","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.23297.1","article-title":"GFF utilities: GffRead and GffCompare","volume":"9","author":"G Pertea","year":"2020","journal-title":"F1000Res"},{"key":"pntd.0013646.ref036","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkl315","article-title":"PAL2NAL: robust conversion of protein sequence alignments into the corresponding codon alignments","volume":"34","author":"M Suyama","year":"2006","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"pntd.0013646.ref037","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/bioinformatics\/bti079","article-title":"HyPhy: hypothesis testing using phylogenies","volume":"21","author":"SLK Pond","year":"2005","journal-title":"Bioinformatics"},{"issue":"4","key":"pntd.0013646.ref038","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"B Langmead","year":"2012","journal-title":"Nat Methods"},{"key":"pntd.0013646.ref039","unstructured":"Garrison Erik GM. Haplotype-based variant detection from short-read sequencing. 2012."},{"issue":"2","key":"pntd.0013646.ref040","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4161\/fly.19695","article-title":"A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3","volume":"6","author":"P Cingolani","year":"2012","journal-title":"Fly (Austin)"},{"issue":"3","key":"pntd.0013646.ref041","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.13004","article-title":"Role of distinct type-IV-secretion systems and secreted effector sets in host adaptation by pathogenic Bartonella species","volume":"21","author":"A Wagner","year":"2019","journal-title":"Cell Microbiol"},{"issue":"2","key":"pntd.0013646.ref042","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0022-2836(85)90206-2","article-title":"Primary structure of the hip gene of Escherichia coli and of its product, the beta subunit of integration host factor","volume":"183","author":"EL Flamm","year":"1985","journal-title":"J Mol Biol"},{"issue":"3","key":"pntd.0013646.ref043","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1128\/JB.187.3.949-960.2005","article-title":"Role of integration host factor in the transcriptional activation of flagellar gene expression in Caulobacter crescentus","volume":"187","author":"RE Muir","year":"2005","journal-title":"J Bacteriol"},{"issue":"3","key":"pntd.0013646.ref044","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1073\/pnas.1212070110","article-title":"DnaA binding locus datA promotes DnaA-ATP hydrolysis to enable cell cycle-coordinated replication initiation","volume":"110","author":"K Kasho","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"pntd.0013646.ref045","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1089\/vbz.2016.2080","article-title":"Molecular detection of candidatus Bartonella mayotimonensis in North American bats","volume":"17","author":"TM Lilley","year":"2017","journal-title":"Vector Borne Zoonotic Dis"},{"issue":"6","key":"pntd.0013646.ref046","doi-asserted-by":"crossref","first-page":"960","DOI":"10.3201\/eid2006.130956","article-title":"Bats as reservoir hosts of human bacterial pathogen, Bartonella mayotimonensis","volume":"20","author":"V Veikkolainen","year":"2014","journal-title":"Emerg Infect Dis"},{"issue":"3","key":"pntd.0013646.ref047","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1128\/CMR.00013-17","article-title":"Bartonella species, an emerging cause of blood-culture-negative endocarditis","volume":"30","author":"U Okaro","year":"2017","journal-title":"Clin Microbiol Rev"},{"issue":"2","key":"pntd.0013646.ref048","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001296","article-title":"Parallel evolution of a type IV secretion system in radiating lineages of the host-restricted bacterial pathogen Bartonella","volume":"7","author":"P Engel","year":"2011","journal-title":"PLoS Genet"},{"issue":"6","key":"pntd.0013646.ref049","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000946","article-title":"The Trw type IV secretion system of Bartonella mediates host-specific adhesion to erythrocytes","volume":"6","author":"M Vayssier-Taussat","year":"2010","journal-title":"PLoS Pathog"},{"issue":"7","key":"pntd.0013646.ref050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0181696","article-title":"Diversity and phylogenetic relationships among Bartonella strains from Thai bats","volume":"12","author":"CD McKee","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"pntd.0013646.ref051","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s00248-021-01935-0","article-title":"Prevalence and genetic diversity of Bartonella Spp. in Northern Bats (Eptesicus nilssonii) and their blood-sucking Ectoparasites in Hokkaido, Japan","volume":"85","author":"K Nabeshima","year":"2023","journal-title":"Microb Ecol"},{"issue":"12","key":"pntd.0013646.ref052","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1038\/ng.2007.38","article-title":"Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors","volume":"39","author":"HL Saenz","year":"2007","journal-title":"Nat Genet"},{"issue":"4","key":"pntd.0013646.ref053","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1021\/bi8019965","article-title":"Integration host factor (IHF) dictates the structure of polyamine-DNA condensates: implications for the role of IHF in the compaction of bacterial chromatin","volume":"48","author":"T Sarkar","year":"2009","journal-title":"Biochemistry"},{"issue":"10","key":"pntd.0013646.ref054","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1128\/JB.02144-12","article-title":"Mlc is a transcriptional activator with a key role in integrating cyclic AMP receptor protein and integration host factor regulation of leukotoxin RNA synthesis in Aggregatibacter actinomycetemcomitans","volume":"195","author":"C Childress","year":"2013","journal-title":"J Bacteriol"},{"issue":"1","key":"pntd.0013646.ref055","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02273-16","article-title":"Negative autogenous control of the master type iii secretion system regulator HrpL in Pseudomonas syringae","volume":"8","author":"C Waite","year":"2017","journal-title":"mBio"},{"issue":"21","key":"pntd.0013646.ref056","doi-asserted-by":"crossref","first-page":"6537","DOI":"10.1128\/jb.179.21.6537-6550.1997","article-title":"Positive regulation of Shigella flexneri virulence genes by integration host factor","volume":"179","author":"ME Porter","year":"1997","journal-title":"J Bacteriol"},{"issue":"6","key":"pntd.0013646.ref057","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1111\/j.1365-2958.2006.05062.x","article-title":"The integration host factor (IHF) integrates stationary-phase and virulence gene expression in Salmonella enterica serovar Typhimurium","volume":"59","author":"MW Mangan","year":"2006","journal-title":"Mol Microbiol"},{"issue":"2","key":"pntd.0013646.ref058","first-page":"000768","article-title":"Reciprocally rewiring and repositioning the Integration Host Factor (IHF) subunit genes in Salmonella enterica serovar Typhimurium: impacts on physiology and virulence","volume":"8","author":"G Pozdeev","year":"2022","journal-title":"Microb Genom"},{"issue":"3","key":"pntd.0013646.ref059","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/j.1365-2958.2004.04316.x","article-title":"Integration host factor is involved in transcriptional regulation of the Brucella abortus virB operon","volume":"54","author":"R Sieira","year":"2004","journal-title":"Mol Microbiol"},{"key":"pntd.0013646.ref060","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.76182","article-title":"Integration host factor regulates colonization factors in the bee gut symbiont Frischella perrara","volume":"12","author":"K Schmidt","year":"2023","journal-title":"Elife"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0013646","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0013646","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:55:37Z","timestamp":1761846937000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0013646"}},"subtitle":[],"editor":[{"given":"Vladimir L.","family":"Motin","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,10,23]]},"references-count":60,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0013646","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,23]]}}}