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Many pathogenic viruses target it to evade the host immunity. Crimean-Congo hemorrhagic fever virus (CCHFV), the causative agent of Crimean-Congo hemorrhagic fever, which features high mortality in humans, has been reported in southeastern Europe, Africa, the Middle East, and Asia. Although a previous study reported that CCHFV antagonizes IFN-I signaling in human cell lines, it is unclear how it inhibits IFN-I signaling. Here we demonstrated that the non-structural protein of CCHFV, NSm, suppresses IFN-I signaling in human cell lines. Furthermore, we discovered that NSm binds to STAT2, an important host protein in IFN-I signaling, and induces its degradation within cells. Taken together, our results imply that NSm suppresses IFN-I signaling by targeting human STAT2.<\/jats:p>","DOI":"10.1371\/journal.pntd.0013695","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T18:39:47Z","timestamp":1762281587000},"page":"e0013695","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Crimean-Congo hemorrhagic fever virus NSm protein inhibits the type I interferon signaling by binding to 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