{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:33:30Z","timestamp":1785389610266,"version":"3.55.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00c3\u00a7\u00c3\u00a3o de Amparo \u00c3\u00a0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-06623-24\u201d Ref. Fundep n\u00ba 31960"],"award-info":[{"award-number":["APQ-06623-24\u201d Ref. Fundep n\u00ba 31960"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This systematic review aims to estimate the prevalence of sarcopenia in people with heart failure (HF) and assess whether there is a difference in sarcopenia prevalence based on the underlying cause of HF, specifically comparing HF due to Chagas (HF-C) disease with HF from other causes (HF-NC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review of randomized controlled trials, cohort studies, cross-sectional studies, and case-control studies was carried out. Individuals with HF over 18 years who had their frequency of sarcopenia evaluated were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 3347 studies were found, of which 199 had their full texts evaluated. A total of 25 records were identified. The prevalence of sarcopenia, as defined by EWGSOP2 criteria, was 23.27% (95%CI 15.4, 33.6). Further, there were differences in sarcopenia prevalence according to the definition used in the studies (p-value\u2009=\u20090.0002). The odds ratio of sarcopenia in people with HF was 2.3 (95%CI 1.1, 4.8). Two studies specifically evaluated sarcopenia in HF-C, reporting a prevalence of 24.2% (95%CI 12.6, 41.5). The odds ratio for sarcopenia in HF-C was 1.93 (95% CI 0.40, 9.30) compared to HF-NC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with HF have an increased risk of developing sarcopenia. However, the prevalence of sarcopenia varies according to the definition used. Furthermore, our findings highlight the hypothesis that the risk of sarcopenia in HF-C might be higher than HF-NC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0013699","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T18:28:26Z","timestamp":1762799306000},"page":"e0013699","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["People with heart failure, sarcopenia and chagas disease: A systematic review and meta-analysis"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0770-9202","authenticated-orcid":true,"given":"Melissa Orlandin","family":"Premaor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suellen de Azevedo","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Henrique Silva Ambr\u00f3sio","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Diniz","family":"Braga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aron Fonseca","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego Silva Assaf","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Cesar Fernandes","family":"Araujo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria do Carmo Pereira","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Felipe Jose Ravic","family":"de Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"issue":"5","key":"pntd.0013699.ref001","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.cardfail.2019.03.007","article-title":"Nutrition, Obesity, and Cachexia in Patients With Heart Failure: A Consensus Statement from the Heart Failure Society of America Scientific Statements Committee","volume":"25","author":"AR Vest","year":"2019","journal-title":"J Card Fail"},{"issue":"2","key":"pntd.0013699.ref002","doi-asserted-by":"crossref","DOI":"10.7326\/AITC202302210","article-title":"Chagas Disease","volume":"176","author":"NS Hochberg","year":"2023","journal-title":"Ann Intern Med"},{"issue":"6","key":"pntd.0013699.ref003","article-title":"SBC Guideline on the Diagnosis and Treatment of Patients with Cardiomyopathy of Chagas Disease - 2023","volume":"120","author":"JA Marin-Neto","year":"2023","journal-title":"Arq Bras Cardiol"},{"issue":"11","key":"pntd.0013699.ref004","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.amjmed.2020.05.022","article-title":"Chagas Disease: Epidemiology and Barriers to Treatment","volume":"133","author":"RM Mills","year":"2020","journal-title":"Am J Med"},{"key":"pntd.0013699.ref005","unstructured":"Organization WH. 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