{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:25:25Z","timestamp":1767176725852,"version":"build-2238731810"},"update-to":[{"DOI":"10.1371\/journal.pntd.0013764","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000}}],"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sant\u00c3\u00a9 Publique France"},{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherches sur le Sida et les H\u00c3\u00a9patites Virales","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Leptospirosis is a zoonotic disease of increasing importance in French Guiana. It particularly affects subjects living in precarious conditions. We aimed to determine the seroprevalence and the risk of exposure to leptospirosis among inhabitants of three informal settlements in French Guiana.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A serological investigation was conducted in 2022 in three informal settlements in the area of Cayenne, the main city of French Guiana. Leptospirosis exposure factors were assessed in volunteers aged\u2009&gt;\u200915 through a standardized questionnaire. Leptospirosis seroprevalence was evaluated with Microscopic Agglutination Test (MAT) using 17 pathogenic\n                      <jats:italic>Leptospira<\/jats:italic>\n                      antigens with a reactivity threshold of 1:100.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 266 participants, median [IQR] age was 42 [34\u201352] and male to female sex ratio was 0.9. Most participants were migrants (96%), mainly from Haiti (83%), and lived in the study area for at least 2 years (82%). Household rodent exposure (89%) and use of other water sources than collective standpoint (92%) were common. An at-risk occupation was reported for 68% of working participants. Leptospirosis seroprevalence was 7.5% (95% CI [4.7-11.4]) with Ballum and Icterohaemorrhagiae as the main serogroups. Foot skin exposure in wet environments was associated with reactive serum (OR 7.6, 95% CI [1.1 - 326.7]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Despite a high theoretical risk of leptospirosis exposure among informal settlements inhabitants, only a few participants were seroreactive for\n                      <jats:italic>Leptospira<\/jats:italic>\n                      . This may suggest that despite at-risk exposures the effective transmission of leptospirosis remains limited within the study area. Broader serological surveys and environmental studies should clarify the areas of at-risk leptospirosis transmission in French Guiana.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0013764","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T18:33:33Z","timestamp":1764009213000},"page":"e0013764","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Leptospirosis seroprevalence and exposure factors in three informal settlements of French Guiana: An opportunistic survey"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6164-311X","authenticated-orcid":true,"given":"Paul","family":"Le Turnier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margot","family":"Oberlis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Lavergne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lo\u00efc","family":"Epelboin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Picardeau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"issue":"9","key":"pntd.0013764.ref001","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003898","article-title":"Global Morbidity and Mortality of Leptospirosis: A Systematic Review","volume":"9","author":"F Costa","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"5","key":"pntd.0013764.ref002","article-title":"Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the Leptospira agent","volume":"8","author":"RDM Felzemburgh","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"issue":"3","key":"pntd.0013764.ref003","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0009256","article-title":"Poverty, sanitation, and Leptospira transmission pathways in residents from four Brazilian slums","volume":"15","author":"H Khalil","year":"2021","journal-title":"PLoS Negl Trop Dis"},{"issue":"4","key":"pntd.0013764.ref004","article-title":"Impact of environment and social gradient on Leptospira infection in urban slums","volume":"2","author":"RB Reis","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0013764.ref005","unstructured":"Agence d\u2019Urbanisme & de D\u00e9veloppement de la Guyane. 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