{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:57:09Z","timestamp":1787021829220,"version":"build-2736575974"},"reference-count":70,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Secretar\u00c3a de Ciencia, Humanidades, Tecnolog\u00c3a e Innovaci\u00c3\u00b3n","award":["CBF-2025-I-2041"],"award-info":[{"award-number":["CBF-2025-I-2041"]}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Cutaneous leishmaniasis (CL) is a neglected tropical disease caused by\n                      <jats:italic>Leishmania spp.<\/jats:italic>\n                      parasites. It poses significant public health challenges among economically marginalized communities in endemic regions like Southeastern Mexico. Here, we developed a mathematical model to describe the transmission dynamics of CL in the Yucatan Peninsula region, focusing on two key sand fly vectors:\n                      <jats:italic>Lutzomyia cruciata<\/jats:italic>\n                      and\n                      <jats:italic>Bichromomyia olmeca<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Transmission was modelled as frequency dependent with Susceptible-Infected dynamics for vectors and rodents, and Susceptible-Exposed-Infected-Susceptible for humans, and accounts for the impact of available blood meals on vector populations. The model was parameterized from published literature for vector and reservoir growth rates and carrying capacities, transmission efficiency, and vector feeding preferences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      The simulations highlight the importance of both vector species in CL transmission, with\n                      <jats:italic>Lu. cruciata<\/jats:italic>\n                      showing a higher preference for human blood, while\n                      <jats:italic>Bi. olmeca<\/jats:italic>\n                      is more frequently associated with rodents. Sensitivity and scenario analyses reveal that the system is highly sensitive to transmission rates and vector feeding preferences, suggesting that\n                      <jats:italic>Bi. olmeca<\/jats:italic>\n                      is necessary to maintain infection among reservoirs, while\n                      <jats:italic>Lu. cruciata<\/jats:italic>\n                      contributes to zoonotic transmission.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, we emphasize that vector species have different roles on leishmaniasis epidemiology due to feeding preferences. Therefore, roviding funding to improve basic knowledge into the epidemiology of this disease, will improve our understanding of its dynamics. Once achieved, policymakers can develop targeted interventions to reduce CL incidence in affected regions to improve the outcomes of public health interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0013786","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T18:39:32Z","timestamp":1767206372000},"page":"e0013786","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Endemic and zoonotic cycles of cutaneous leishmaniasis depend on vector feeding preferences: An epidemiological model for Southeastern Mexico"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3608-5328","authenticated-orcid":true,"given":"Gerardo","family":"Mart\u00edn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar J.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsy Nallelli","family":"Lor\u00eda-Cervera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Celia","family":"Montes de Oca-Aguilar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"issue":"9","key":"pntd.0013786.ref001","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S1473-3099(07)70209-8","article-title":"Cutaneous leishmaniasis","volume":"7","author":"R Reithinger","year":"2007","journal-title":"Lancet Infect Dis"},{"issue":"9496","key":"pntd.0013786.ref002","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/S0140-6736(05)67629-5","article-title":"Advances in leishmaniasis","volume":"366","author":"HW Murray","year":"2005","journal-title":"Lancet"},{"issue":"5","key":"pntd.0013786.ref003","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S1473-3099(16)00003-7","article-title":"Global burden of cutaneous leishmaniasis: a cross-sectional analysis from the Global Burden of Disease Study 2013","volume":"16","author":"C Karimkhani","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"pntd.0013786.ref004","first-page":"135","article-title":"Vulnerabilities to and the Socioeconomic and Psychosocial Impacts of the Leishmaniases: A Review","volume":"12","author":"G Grifferty","year":"2021","journal-title":"Res Rep Trop Med"},{"key":"pntd.0013786.ref005","article-title":"Case study for a vaccine against leishmaniasis","author":"J Alvar","year":"2013","journal-title":"Vaccine"},{"key":"pntd.0013786.ref006","unstructured":"Pan American Health Organization. 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