{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:28:33Z","timestamp":1790602113500,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0013795","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000}}],"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>\n                    Opportunistic and endemic mycoses represent a significant global health concern, particularly in Brazil. In the northeastern state of Pernambuco (PE), sporotrichosis has become a rapidly escalating public health challenge, evidenced by a notable increase in hospital admissions, despite its mostly outpatient nature. The present study, therefore, aimed to investigate the epidemiological and clinical profile of mycosis-related hospitalizations in PE from 2016 to 2024, with a primary focus on the burden of sporotrichosis. This statewide surveillance study used data from Brazil\u2019s Unified Health System Hospital Information System (SIH\/SUS) to conduct a descriptive and comparative assessment of hospitalizations for ten fungal diseases in PE and nationally. Incidence rates and the Error, Trend, Seasonality (ETS) framework were applied to forecast case numbers for 2025. A total of 794 hospitalizations were recorded in PE during the study period. The most prevalent infections were aspergillosis (23.0%), sporotrichosis (17.5%), cryptococcosis (15.1%), and chromoblastomycosis (13.6%), with an overall mortality rate of 10.5%. Hospitalizations for sporotrichosis rose from five cases in 2016\u201328 in 2021, with local incidence rates surpassing the national average. This implantation mycosis showed a marked concentration in Recife, reflecting the zoonotic spread of\n                    <jats:italic>Sporothrix brasiliensis<\/jats:italic>\n                    in urban areas. Notably, 46.0% of sporotrichosis cases were classified as unspecified, underscoring gaps in reporting. Among specified cases, the lymphocutaneous form predominated (18.7%), followed by disseminated disease (17.3%). Forecasts for 2025 indicate a persistently high hospitalization burden. These findings highlight a pressing public health issue in PE. The surge in sporotrichosis cases and the high share of severe and unspecified forms point to weaknesses in diagnosis and data recording. Tackling this emerging endemic-epidemic threat requires improved surveillance, mandatory notification, and better data capture in SIH\/SUS, alongside integrated actions across human, animal, and environmental health sectors.\n                  <\/jats:p>","DOI":"10.1371\/journal.pntd.0013795","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T19:01:17Z","timestamp":1764615677000},"page":"e0013795","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["From neglected to notable: A growing public health challenge driven by hospitalization for sporotrichosis in Pernambuco, Northeast Brazil (2016\u20132024)"],"prefix":"10.1371","volume":"19","author":[{"given":"Filipe","family":"Prohaska-Batista","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7295-0828","authenticated-orcid":true,"given":"Francelise","family":"Bridi Cavassin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"de Queiroz-Telles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,12,1]]},"reference":[{"issue":"7","key":"pntd.0013795.ref001","doi-asserted-by":"crossref","DOI":"10.1016\/S1473-3099(23)00692-8","article-title":"Global incidence and mortality of severe fungal disease","volume":"24","author":"DW Denning","year":"2024","journal-title":"Lancet Infect Dis"},{"issue":"5","key":"pntd.0013795.ref002","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11046-025-00981-3","article-title":"Addressing Critical Fungal Pathogens Under a One Health Perspective: Key Insights from the Portuguese Association of Medical Mycology","volume":"190","author":"R Sabino","year":"2025","journal-title":"Mycopathologia"},{"issue":"3","key":"pntd.0013795.ref003","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/myc.12427","article-title":"The burden of serious human fungal infections in Brazil","volume":"59","author":"J Giacomazzi","year":"2016","journal-title":"Mycoses"},{"key":"pntd.0013795.ref004","unstructured":"Brasil. Minist\u00e9rio da Sa\u00fade. Esporotricose humana passa a ser de notifica\u00e7\u00e3o compuls\u00f3ria Internet]. Bras\u00edlia: Minist\u00e9rio da Sa\u00fade; 2025."},{"key":"pntd.0013795.ref005","volume-title":"Global report on neglected tropical diseases 2024","author":"World Health Organization","year":"2024"},{"issue":"11","key":"pntd.0013795.ref006","doi-asserted-by":"crossref","DOI":"10.1016\/S1473-3099(17)30306-7","article-title":"Neglected endemic mycoses","volume":"17","author":"F Queiroz-Telles","year":"2017","journal-title":"Lancet Infect Dis"},{"issue":"6","key":"pntd.0013795.ref007","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.jaad.2024.03.056","article-title":"Dermatologic fungal neglected tropical diseases-Part I. Epidemiology and clinical features","volume":"92","author":"KL Curtis","year":"2025","journal-title":"J Am Acad Dermatol"},{"key":"pntd.0013795.ref008"},{"issue":"7","key":"pntd.0013795.ref009","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/zph.12504","article-title":"Sporotrichosis in Southern Brazil, towards an epidemic?","volume":"65","author":"VR Poester","year":"2018","journal-title":"Zoonoses Public Health"},{"issue":"2","key":"pntd.0013795.ref010","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s42770-022-00713-5","article-title":"A neglected disease. Human sporotrichosis in a densely populated urban area in S\u00e3o Paulo, Brazil: clinical-epidemiological and therapeutic aspects","volume":"53","author":"AA Bittencourt","year":"2022","journal-title":"Braz J Microbiol"},{"issue":"7","key":"pntd.0013795.ref011","first-page":"1330","article-title":"Rising Incidence of Sporothrix brasiliensis Infections, Curitiba, Brazil, 2011-2022","volume":"29","author":"RCR Cognialli","year":"2023","journal-title":"Emerg Infect Dis"},{"issue":"7","key":"pntd.0013795.ref012","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0012328","article-title":"Zoonotic Sporotrichosis outbreak: Emerging public health threat in the Amazon State, Brazil","volume":"18","author":"VA Mesquita","year":"2024","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0013795.ref013"},{"key":"pntd.0013795.ref014","unstructured":"Santos, ZMG. Vigil\u00e2ncia da esporotricose humana no Brasil: uma contribui\u00e7\u00e3o para a formula\u00e7\u00e3o da pol\u00edtica p\u00fablica disserta\u00e7\u00e3o]. Bras\u00edlia: Escola Fiocruz de Governo, Funda\u00e7\u00e3o Oswaldo Cruz; 2019. 159 p."},{"key":"pntd.0013795.ref015","unstructured":"Brasil. Minist\u00e9rio da Sa\u00fade. Portaria GM\/MS n\u00ba 6.734, de 31 de mar\u00e7o de 2025. Altera a Portaria de Consolida\u00e7\u00e3o GM\/MS n\u00ba 5, de 28 de setembro de 2017, para incluir a esporotricose na Lista Nacional de Notifica\u00e7\u00e3o Compuls\u00f3ria de doen\u00e7as, agravos e eventos de sa\u00fade p\u00fablica [Internet]. 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