{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:13:45Z","timestamp":1786407225315,"version":"build-2736575974"},"reference-count":82,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministerio de Ciencia Tecnologia e Innovacion","award":["82487"],"award-info":[{"award-number":["82487"]}]},{"DOI":"10.13039\/501100005278","name":"University of Antioquia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005278","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>\n                    Thirty-one species of\n                    <jats:italic>Micrurus<\/jats:italic>\n                    (coral snakes) are distributed in Colombia. However, functional and proteomic analyses of their venoms have only been performed on six of them.\n                    <jats:italic>Micrurus camilae<\/jats:italic>\n                    is endemic to Colombia, and no information exists regarding its venom. The proteome of\n                    <jats:italic>M. camilae<\/jats:italic>\n                    venom, its biochemical and toxic activities, immunorecognition, and neutralization by commercial equine antivenoms and an experimental one prepared in rabbits are here reported. In addition, the phylogenetic position of\n                    <jats:italic>M. camilae<\/jats:italic>\n                    within the genus was explored. The venom was characterized by RP-HPLC, SDS-PAGE, and nESI-MS\/MS, and functional analyses were performed using\n                    <jats:italic>in vitro<\/jats:italic>\n                    (proteolytic, coagulant, phospholipase A\n                    <jats:sub>2<\/jats:sub>\n                    , and L-amino acid oxidase activity) and\n                    <jats:italic>in vivo<\/jats:italic>\n                    (myotoxic, edematogenic, hemorrhagic) assays. Immunorecognition and neutralization were evaluated using ELISA and mouse lethality, respectively. To determine phylogenetic relationships, sequences of the mitochondrial\n                    <jats:italic>ND4<\/jats:italic>\n                    gene from 48\n                    <jats:italic>Micrurus<\/jats:italic>\n                    species were analyzed. The venom proteome revealed a PLA\n                    <jats:sub>2<\/jats:sub>\n                    -rich phenotype and identified 17 protein families, the four most abundant being PLA\n                    <jats:sub>2<\/jats:sub>\n                    , LAO, 3FTx, and MP. The myotoxic and hemorrhagic activities observed in mice correlated with the relative abundance of PLA\n                    <jats:sub>2<\/jats:sub>\n                    s and MPs, respectively. Furthermore, the i.p. lethal effect in mice was associated with only one fraction, a 3FTx. Two commercial equine antivenoms (INS-anticoral and ICP-anticoral) immunologically recognized both the whole venom and the chromatographic fractions by ELISA. However, they did not neutralize venom lethality in mice in a preincubation assay. On the other hand, the experimental rabbit antivenom was shown to recognize the whole venom and its fractions and, although it did not completely neutralize lethality, it prolonged mouse survival by several hours compared to the venom-only control. Our phylogenetic hypothesis showed\n                    <jats:italic>M. camilae<\/jats:italic>\n                    within the mipartitus group as a sister species of\n                    <jats:italic>M. mipartitus<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1371\/journal.pntd.0013941","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T18:44:06Z","timestamp":1771353846000},"page":"e0013941","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["First characterization of the venom of the endemic coral snake Micrurus camilae (Serpentes: Elapidae) from Colombia: Proteome, toxic activities, immunorecognition, and neutralization by antivenoms"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9816-3697","authenticated-orcid":true,"given":"Jeisson","family":"G\u00f3mez-Robles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Rey-Su\u00e1rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli\u00e1n","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Saldarriaga-C\u00f3rdoba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmood","family":"Sasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Lomonte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitelbina","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"pntd.0013941.ref001","unstructured":"who.int [Internet]. Swiss: World Health Organization (WHO): Snakebite Envenoming; c2024 [cited 2024 Dec]. Available from: https:\/\/www.who.int"},{"issue":"12","key":"pntd.0013941.ref002","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3390\/toxins8120351","article-title":"Priority actions and progress to substantially and sustainably reduce the mortality, morbidity and socioeconomic burden of tropical snakebite","volume":"8","author":"RA Harrison","year":"2016","journal-title":"Toxins (Basel)"},{"issue":"10","key":"pntd.0013941.ref003","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0008727","article-title":"Interventions for the management of snakebite envenoming: an overview of systematic reviews","volume":"14","author":"S Bhaumik","year":"2020","journal-title":"PLoS Negl Trop Dis"},{"issue":"3","key":"pntd.0013941.ref004","doi-asserted-by":"crossref","DOI":"10.1016\/S2214-109X(21)00549-0","article-title":"Assessment of the effect of snakebite on health and socioeconomic factors using a One Health perspective in the Terai region of Nepal: a cross-sectional study","volume":"10","author":"S Babo Martins","year":"2022","journal-title":"Lancet Glob Health"},{"key":"pntd.0013941.ref005","doi-asserted-by":"crossref","first-page":"100147","DOI":"10.1016\/j.toxcx.2022.100147","article-title":"Multifaceted community health education programs as powerful tools to mitigate snakebite-induced deaths, disabilities, and socioeconomic burden","volume":"17","author":"S Vaiyapuri","year":"2022","journal-title":"Toxicon X"},{"issue":"6","key":"pntd.0013941.ref006","article-title":"Snakebites and their impact on disability","volume":"12","author":"IF Funes","year":"2024","journal-title":"Medical Research Archives"},{"issue":"1","key":"pntd.0013941.ref007","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1186\/s40359-024-01964-7","article-title":"The bridge relationships of PTSD and depression symptoms among snakebite victims: a cross-sectional community-based survey","volume":"12","author":"Y Chen","year":"2024","journal-title":"BMC Psychol"},{"issue":"11","key":"pntd.0013941.ref008","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0050218","article-title":"The global burden of snakebite: a literature analysis and modelling based on regional estimates of envenoming and deaths","volume":"5","author":"A Kasturiratne","year":"2008","journal-title":"PLoS Med"},{"issue":"2","key":"pntd.0013941.ref009","first-page":"86","article-title":"Snake venoms: from research to treatment","volume":"54","author":"B Lomonte","year":"2012","journal-title":"Acta M\u00e9dica Costarricense"},{"issue":"1","key":"pntd.0013941.ref010","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1056\/NEJMra2105228","article-title":"Snake Envenomation","volume":"386","author":"SA Seifert","year":"2022","journal-title":"N Engl J Med"},{"issue":"1","key":"pntd.0013941.ref011","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s40475-023-00309-5","article-title":"Snakebites in the Americas: a Neglected Problem in Public Health","volume":"11","author":"EA Fern\u00e1ndez C","year":"2023","journal-title":"Curr Trop Med Rep"},{"key":"pntd.0013941.ref012","unstructured":"Uetz P, Ho\u0161ek J [Internet]. Virginia. The Reptile Database. c2025 \u2013 [cited 2025 May 30]. Available from: http:\/\/www.reptiledatabase.org"},{"key":"pntd.0013941.ref013","doi-asserted-by":"crossref","unstructured":"Ins.gov.co [Internet]: Instituto Nacional de Salud: Protocolo de Vigilancia en Salud P\u00fablica de Accidente Of\u00eddico (SIVIGILA); c2024 \u2013 [cited 2025 sep 1]. https:\/\/www.ins.gov.co\/Direcciones\/Vigilancia\/Paginas\/SIVIGILA.aspx","DOI":"10.33610\/400816ruxhbr"},{"key":"pntd.0013941.ref014","unstructured":"Walteros D, Paredes A, Le\u00f3n LJ. (Ministerio de Salud y Protecci\u00f3n Social). Protocolo de Vigilancia en Salud Publica. Accidente Of\u00eddico. Bogot\u00e1: Grupo de Enfermedades Transmisibles, Equipo de Zoonosis; 2014 Agu. Report.: PRO-R02.002 \u2013 versi\u00f3n 02."},{"key":"pntd.0013941.ref015","unstructured":"Rojas A. (Ministerio de Salud y Protecci\u00f3n Social). Accidente of\u00eddico Colombia. Bogot\u00e1. Grupo de Enfermedades Transmisibles, Equipo de Zoonosis; 2017 Apr. Report.: FOR-R02.4000-001 \u2013 versi\u00f3n 03. 1\u201316."},{"key":"pntd.0013941.ref016","unstructured":"Rojas A. (Ministerio de Salud y Protecci\u00f3n Social). Accidente of\u00eddico Colombia. Bogot\u00e1. Grupo de Enfermedades Transmisibles, Equipo de Zoonosis; 2019 May. Report.: FOR-R02.4000-001 \u2013 versi\u00f3n 04. 1\u201333."},{"key":"pntd.0013941.ref017","doi-asserted-by":"crossref","unstructured":"Otero-Pati\u00f1o. Snake bites in Colombia. 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Lomonte","year":"2016","journal-title":"Toxicon"},{"key":"pntd.0013941.ref021","first-page":"485","article-title":"Venomic analyses of coralsnakes.","volume-title":")","author":"B Lomonte","year":"2021"},{"issue":"2","key":"pntd.0013941.ref022","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.jprot.2011.09.003","article-title":"Proteomic and biological characterization of the venom of the redtail coral snake, Micrurus mipartitus (Elapidae), from Colombia and Costa Rica","volume":"75","author":"P Rey-Su\u00e1rez","year":"2011","journal-title":"J Proteomics"},{"key":"pntd.0013941.ref023","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jprot.2016.02.006","article-title":"Integrative characterization of the venom of the coral snake Micrurus dumerilii (Elapidae) from Colombia: Proteome, toxicity, and cross-neutralization by antivenom","volume":"136","author":"P Rey-Su\u00e1rez","year":"2016","journal-title":"J 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Nicholas","year":"1997","journal-title":"Embnewnews"},{"issue":"10","key":"pntd.0013941.ref041","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1093\/molbev\/msy159","article-title":"MACSE v2: Toolkit for the Alignment of Coding Sequences Accounting for Frameshifts and Stop Codons","volume":"35","author":"V Ranwez","year":"2018","journal-title":"Mol Biol Evol"},{"issue":"1","key":"pntd.0013941.ref042","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/1755-0998.13096","article-title":"PhyloSuite: An integrated and scalable desktop platform for streamlined molecular sequence data management and evolutionary phylogenetics studies","volume":"20","author":"D Zhang","year":"2020","journal-title":"Mol Ecol Resour"},{"key":"pntd.0013941.ref043","doi-asserted-by":"crossref","unstructured":"Nguyen LT, Schmidt HA, Von Haeseler A, Minh BQ. IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. Molecular Biology and Evolution. 2015; 32:268\u2013274. doi: 10.1093\/molbev\/msu300","DOI":"10.1093\/molbev\/msu300"},{"issue":"6","key":"pntd.0013941.ref044","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nmeth.4285","article-title":"ModelFinder: fast model selection for accurate phylogenetic estimates","volume":"14","author":"S Kalyaanamoorthy","year":"2017","journal-title":"Nat Methods"},{"issue":"12","key":"pntd.0013941.ref045","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1093\/bioinformatics\/btg180","article-title":"MrBayes 3: Bayesian phylogenetic inference under mixed models","volume":"19","author":"F Ronquist","year":"2003","journal-title":"Bioinformatics"},{"key":"pntd.0013941.ref046","unstructured":"Rambaut, A. & Drummond, A.J. (2009) Tracer Version 1.5. MCMC Trace Analysis Packpage. (accessed 01 January 2025). 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Methods"},{"issue":"10","key":"pntd.0013941.ref050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0109846","article-title":"Synergism between basic Asp49 and Lys49 phospholipase A2 myotoxins of viperid snake venom in vitro and in vivo","volume":"9","author":"D Mora-Obando","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"pntd.0013941.ref051","first-page":"949","article-title":"Development of simple standard assay procedures for the characterization of snake venom","volume":"61","author":"RD Theakston","year":"1983","journal-title":"Bull World Health Organ"},{"issue":"1","key":"pntd.0013941.ref052","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1006\/abio.2001.5381","article-title":"A spectrophotometric microplate assay for L-amino acid oxidase","volume":"298","author":"M Kishimoto","year":"2001","journal-title":"Anal 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Biophys"},{"issue":"2","key":"pntd.0013941.ref059","first-page":"285","article-title":"Geographic distribution: Micrurus camilae","volume":"45","author":"E Alzate","year":"2014","journal-title":"Herpetological Review"},{"issue":"5","key":"pntd.0013941.ref060","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2174\/187152811797200669","article-title":"Antivenoms for snakebite envenomings","volume":"10","author":"JM Guti\u00e9rrez","year":"2011","journal-title":"Inflamm Allergy Drug Targets"},{"key":"pntd.0013941.ref061","article-title":"Biological activities and action mechanisms of coral snake venoms.","author":"JM Gutierrez","year":"2021","journal-title":"Advances in coral snake biology with emphasis on South America"},{"key":"pntd.0013941.ref062","doi-asserted-by":"crossref","first-page":"107658","DOI":"10.1016\/j.toxicon.2024.107658","article-title":"Quantifying venom production: A study on Micrurus snakes in Mexico","volume":"240","author":"E 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