{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:28:57Z","timestamp":1791433737115,"version":"4.3.3"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32160840 and 32560866"],"award-info":[{"award-number":["32160840 and 32560866"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Key R&D and Conversion Plan of Qinghai Province","award":["2025-QY-227"],"award-info":[{"award-number":["2025-QY-227"]}]},{"name":"National Key Research and Development Plan of China","award":["2022YFE0108100"],"award-info":[{"award-number":["2022YFE0108100"]}]},{"name":"Open Project of State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases","award":["RCGHCRB202506"],"award-info":[{"award-number":["RCGHCRB202506"]}]},{"name":"the Qinghai Province \u00e2\u20ac\u0153Kunlun Talents High-end Innovation and Entrepreneurial Talents\u00e2\u20ac Talent Training Project"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>\n                    The severe endemicity of\n                    <jats:italic>Echinococcus<\/jats:italic>\n                    spp. on the Qinghai\u2012Tibet Plateau (QTP) necessitates the identification of key risk factors influencing its transmission and distribution in northeastern QTP sylvatic cycles, alongside multifactorial interactions within the \"environment\u2013host\u2013parasite\"\u00a0system. Field monitoring,\u00a0multi source\u00a0remote sensing data, and geographic detector techniques were integrated to elucidate the coupling relationships between the distribution and dissemination of\n                    <jats:italic>Echinococcus<\/jats:italic>\n                    spp. and geographical environmental factors. Land surface temperature (LST) was identified as a critical risk factor, exhibiting a significant negative correlation with\n                    <jats:italic>Echinococcus<\/jats:italic>\n                    spp. distribution (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.01), while the interactive effects between factors surpassed individual impacts. The highest potential infection risk was localized in areas overlapping the northeastern plateau and the Three-River-Source core region, characterized by pronounced temperature fluctuations, low humidity, and intense radiation. On the basis of these findings, an ecoepidemiological hypothesis is proposed: the unique QTP habitat facilitates the evolution of a\u00a0multi host\u00a0parasitic system in\n                    <jats:italic>Echinococcus<\/jats:italic>\n                    spp.; subsequent host-mediated environmental modifications optimize dispersal conditions, jointly amplifying\n                    <jats:italic>Echinococcus<\/jats:italic>\n                    spp. transmission; and the synergistic coupling of \"environmental-host-pathogen\" dynamics underpins\n                    <jats:italic>Echinococcus<\/jats:italic>\n                    spp. endemicity on the QTP. This study provides a technical foundation for early risk warning and targeted control strategies for natural\n                    <jats:italic>Echinococcus<\/jats:italic>\n                    spp. foci.\n                  <\/jats:p>","DOI":"10.1371\/journal.pntd.0013985","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T18:27:29Z","timestamp":1771525649000},"page":"e0013985","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Synergistic effects of multifactor interactions on the transmission of Echinococcus spp. on the Qinghai\u2013Tibet Plateau"],"prefix":"10.1371","volume":"20","author":[{"given":"Ao","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongrun","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Duo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuying","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3354-9107","authenticated-orcid":true,"given":"Yong","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"issue":"9392","key":"pntd.0013985.ref001","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/S0140-6736(03)14573-4","article-title":"Echinococcosis","volume":"362","author":"DP 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