{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T20:56:15Z","timestamp":1787604975529,"version":"build-2736575974"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Emergency Response Mechanism Operation Program","award":["102393220020010000017"],"award-info":[{"award-number":["102393220020010000017"]}]},{"name":"Comprehensive Prevention and Control of Diseases program","award":["1023932600200110000011"],"award-info":[{"award-number":["1023932600200110000011"]}]},{"name":"Chinese National Science and Technology Major Project","award":["2018ZX10101002-003-002"],"award-info":[{"award-number":["2018ZX10101002-003-002"]}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rabies continues to pose a significant public health challenge in China. To offer a scientific foundation for formulating rabies prevention and control strategies, this study conducted a national survey to comprehend the current status of rabies post-exposure prophylaxis (PEP) clinics construction and the surveillance of rabies-exposed individuals in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Chinese Center for Disease Control and Prevention (CCDC) developed a national rabies prevention and control questionnaire, and conducted a survey across 31 provinces in Mainland China. The questionnaire was completed by the person in charge of rabies prevention and control in each provincial disease prevention and control institution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>By the end of 2022, 24,304 PEP clinics were reported in Mainland China. The number of PEP clinics per capita in China is 1.75 per 100,000. Nationwide, 47% of PEP clinics were capable of handling category III exposures. A total of 10,770,543 PEP clinic visits were reported. East China reported the highest number of rabies exposures (4,022,265). Among category III exposures, only 35% reported using rabies immunoglobulin (RIG). 97% of rabies exposures were attacked by dogs or cats. In South China, exposures caused by cats were nearly as frequent as those caused by dogs (47% and 48% respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The distribution of PEP clinics across China is uneven. This pattern appears broadly consistent with the historical geographic distribution of rabies risk, which may reflect a risk-informed allocation of resources. We recommended implementing tiered prevention and control strategies, with emphasis on enhancing the stockpile of RIG, dogs and cats population management, and health education in regions with higher rabies exposure risks. In provinces with a high incidence of rabies outbreaks, it is essential to actively advocate for the inclusion of rabies vaccines and RIG in the reimbursement scope of the New Rural Cooperative Medical Insurance Scheme, and raise the reimbursement rate and limit. The \u201cOne Health\u201d approach should be adopted, including mandatory immunization and surveillance management systems for dogs and cats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0014011","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T17:24:41Z","timestamp":1782149081000},"page":"e0014011","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Survey on the current status of rabies post-exposure prophylaxis clinics construction and the surveillance of rabies-exposed individuals in China, 2022"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7731-7936","authenticated-orcid":true,"given":"Qian","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Rui","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Han","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Jian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Long","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Wu","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-Lan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"issue":"2","key":"pntd.0014011.ref001","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S1474-4422(02)00041-8","article-title":"Human rabies: a disease of complex neuropathogenetic mechanisms and diagnostic challenges","volume":"1","author":"T Hemachudha","year":"2002","journal-title":"Lancet Neurol"},{"issue":"4","key":"pntd.0014011.ref002","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1001\/jama.2022.22254","article-title":"Rabies","volume":"329","author":"J Jin","year":"2023","journal-title":"JAMA"},{"issue":"39","key":"pntd.0014011.ref003","doi-asserted-by":"crossref","first-page":"825","DOI":"10.46234\/ccdcw2021.204","article-title":"Progress in the Development of Animal Rabies Vaccines in China","volume":"3","author":"C Yin","year":"2021","journal-title":"China CDC Wkly"},{"issue":"5","key":"pntd.0014011.ref004","doi-asserted-by":"crossref","first-page":"121","DOI":"10.15585\/mmwr.mm6905a1","article-title":"Human rabies - 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