{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:01:21Z","timestamp":1772895681146,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pntd.0014052","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000}}],"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170510"],"award-info":[{"award-number":["32170510"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019091","name":"Key Research and Development Program of Hunan Province of China","doi-asserted-by":"publisher","award":["2024DK2001"],"award-info":[{"award-number":["2024DK2001"]}],"id":[{"id":"10.13039\/501100019091","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ5422"],"award-info":[{"award-number":["2024JJ5422"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Changsha Major Special Project of Science and Technology","award":["kh2301027"],"award-info":[{"award-number":["kh2301027"]}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>\n                    <jats:italic>Toxoplasma gondii<\/jats:italic>\n                    (\n                    <jats:italic>T. gondii<\/jats:italic>\n                    ) is an intracellular parasite that infects nearly all warm-blooded animals, including humans. The susceptibility to\n                    <jats:italic>T. gondii<\/jats:italic>\n                    infection varies among hosts. In this study, we found that\n                    <jats:italic>Microtus fortis<\/jats:italic>\n                    (\n                    <jats:italic>M. fortis<\/jats:italic>\n                    ) exhibited a naturally high level of resistance to the\n                    <jats:italic>T. gondii<\/jats:italic>\n                    RH strain, as evidenced by survival assays. We further observed that\n                    <jats:italic>M. fortis<\/jats:italic>\n                    activated the complement system via the lectin pathway to lyse\n                    <jats:italic>T. gondii<\/jats:italic>\n                    tachyzoites, whereas serum from Kunming (KM) mice showed no such effect. Furthermore, the ability of\n                    <jats:italic>M. fortis<\/jats:italic>\n                    to clear\n                    <jats:italic>T. gondii<\/jats:italic>\n                    tachyzoites was significantly impaired when the complement system was inhibited by cobra venom factor (CVF). These findings indicate that\n                    <jats:italic>M. fortis<\/jats:italic>\n                    exhibits a naturally high resistance to\n                    <jats:italic>T. gondii<\/jats:italic>\n                    . This resistance is mediated, in part, by the complement system, which is activated through the lectin pathway and directly lyses extracellular tachyzoites. Thus, the complement system plays an essential role in controlling\n                    <jats:italic>T. gondii<\/jats:italic>\n                    infection in this species.\n                  <\/jats:p>","DOI":"10.1371\/journal.pntd.0014052","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T18:30:32Z","timestamp":1772476232000},"page":"e0014052","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["The resistance to Toxoplasma gondii in Microtus fortis is associated with the activation of the complement lectin 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