{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T19:22:25Z","timestamp":1772738545306,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pntd.0014061","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000}}],"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS064901"],"award-info":[{"award-number":["R01NS064901"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Neurocysticercosis (NCC) is a common cause of epilepsy in low- and middle-income countries (LMICs). Few studies have described neuroimaging findings in individuals with headaches in addition to epilepsy. Our aim was therefore to describe the types of NCC lesions seen on cerebral computed tomography (cCT), among participants with progressively worsening severe headaches (PWSH) and epilepsy living in 60 villages in Burkina Faso, and to determine the prevalence of NCC in these groups,.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from a screening questionnaire for epilepsy and PWSH and subsequent neurological examination were gathered as part of a baseline cross-sectional component of a cluster randomized controlled trial conducted between February 2011 and January 2012. Those screening positive and a sub-sample of individuals screening negative were investigated by one of the two physicians in the field. Participants for whom the physician confirmed the presence of the neurological signs\/symptoms of interest were invited for cCT. Participants receiving cCT were tested for the presence of circulating cysticercal antigens using the B158\/B60 Ag-ELISA and of antibodies using the rT24H EITB. For all individuals undergoing cCT, observed lesions were radiology categorized as active, degenerated or inactive based on recommendations from the literature, or uncertain, when radiologists were unsure whether they met the definitions. These individuals were finally clinically categorized as definitive or probable cases of NCC according to the internationally recognized diagnostic criteria for NCC, or as uncertain cases of NCC when radiologists were unsure about the lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 249 individuals were diagnosed with the neurological signs\/symptoms of interest by the physicians. Upon further review by the neurologist, 9 were found to have no neurological signs\/symptoms of interest, 109 were diagnosed with epilepsy, 116 with PWSH, and 15 with both. In total, there were 17 definitive NCC cases, 13 probable cases, and 15 cases with an uncertain NCC diagnosis. Among individuals with epilepsy and PWSH, the prevalence of NCC (based on the clinical categorization as definitive or probable NCC cases) was 16.9% (21\/124, 95% CI: 10.8%-24.7%) and 7.6% (10\/131, 95% CI: 3.7%-13.6%), respectively. Of the definitive or probable NCC cases, 46.7% tested positive for the rT24H EITB (14\/30), and 33.3% had a positive Ag-ELISA result (10\/30). Among these cases, there were a total of 19 with active lesions, of which 11 showed viable lesions with a scolex, and 6 without, and 2 with degenerating lesions), whereas 29 had inactive (calcified) lesions including 11 mixed lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      This study is one of the first to provide an estimate for the prevalence of NCC in people with PWSH on the African continent. Furthermore, the findings confirm significant regional variation in the prevalence of NCC cases in people with epilepsy and underscore the need for further research into the inflammatory response to\n                      <jats:italic>T. solium<\/jats:italic>\n                      larvae. Limitations included diagnostic challenges, time delays between assessments, and potential underestimation of the prevalence of NCC due to neuroimaging constraints.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0014061","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T18:40:28Z","timestamp":1772131228000},"page":"e0014061","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of neurocysticercosis and its characteristics among people with epileptic seizures and progressively worsening severe headaches in 60 villages in three provinces of Burkina 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