{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T21:10:36Z","timestamp":1774386636113,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pntd.0014105","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000}}],"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>\n                    Ascomycetes belonging to the\n                    <jats:italic>Histoplasma capsulatum<\/jats:italic>\n                    species complex can cause severe manifestations in patients with disseminated histoplasmosis. Based on data from hemagglutination assays and histopathological findings related to\n                    <jats:italic>H. capsulatum<\/jats:italic>\n                    , we investigated their potential role in the disseminated intravascular hemagglutination events. Human erythrocyte hemagglutination was produced with\n                    <jats:italic>H. capsulatum<\/jats:italic>\n                    yeasts of 10 isolates\/strains, belonging to different phylogenetic species and lineages. Hemagglutination assays were inhibited by pre-incubating their yeasts with \u03b2-galactose, ratifying previously published data for a unique\n                    <jats:italic>H. capsulatum<\/jats:italic>\n                    clinical strain. This lectin was partially purified through affinity chromatography using erythrocyte stroma, and its hemagglutinating activity was confirmed. Results underlined the consistent involvement of a \u03b2-galactose-binding lectin of\n                    <jats:italic>H. capsulatum<\/jats:italic>\n                    yeasts in hemagglutination assays by using genetically distinct\n                    <jats:italic>H. capsulatum<\/jats:italic>\n                    species, which support its conserved origin. Serendipitous findings in histopathological sections of human and bat tissues supported that\n                    <jats:italic>H. capsulatum<\/jats:italic>\n                    yeasts adhered to erythrocytes, consistent with intravascular hemagglutination. Hence, in hosts with disseminated histoplasmosis and sepsis, we hypothesized that this\n                    <jats:italic>H. capsulatum<\/jats:italic>\n                    lectin may favor an intravascular hemagglutination, which could occur concomitantly with a procoagulant state, aggravating hypoxia and leading to disseminated intravascular coagulation, a lethal complication.\n                  <\/jats:p>","DOI":"10.1371\/journal.pntd.0014105","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T17:35:38Z","timestamp":1773164138000},"page":"e0014105","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["A potential histoplasmosis pathogenesis mechanism mediated by a lectin of Histoplasma capsulatum with affinity to \u03b2-galactose, favoring intravascular hemagglutination"],"prefix":"10.1371","volume":"20","author":[{"given":"Ivan","family":"Ramos-Mart\u00ednez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenia","family":"Flores-Robles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Rodr\u00edguez-Arellanes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"Zenteno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"P\u00e9rez-Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5011-5939","authenticated-orcid":true,"given":"Maria Lucia","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"issue":"7","key":"pntd.0014105.ref001","doi-asserted-by":"crossref","DOI":"10.1128\/aem.02010-21","article-title":"Considerations about the geographic distribution of Histoplasma species","volume":"88","author":"ML Taylor","year":"2022","journal-title":"Appl Environ Microbiol"},{"key":"pntd.0014105.ref002","doi-asserted-by":"crossref","DOI":"10.1016\/j.idcr.2021.e01270","article-title":"Disseminated intravascular coagulation from disseminated histoplasmosis in uncontrolled HIV - Case report","volume":"26","author":"JL Cooper","year":"2021","journal-title":"IDCases"},{"issue":"2","key":"pntd.0014105.ref003","article-title":"Disseminated histoplasmosis presenting as acute respiratory distress syndrome and disseminated intravascular coagulation in an HIV positive immigrant from Central America","volume":"14","author":"R Pata","year":"2022","journal-title":"Cureus"},{"issue":"3","key":"pntd.0014105.ref004","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/13693780310001644734","article-title":"Histoplasma capsulatum yeast cells attach and agglutinate human erythrocytes","volume":"42","author":"ML Taylor","year":"2004","journal-title":"Med Mycol"},{"key":"pntd.0014105.ref005","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/mmy.38.s1.113.123","article-title":"Pathogenesis II: fungal responses to host responses: interaction of host cells with fungi","author":"MJ Mendes-Giannini","year":"2000","journal-title":"Med Mycol"},{"issue":"7","key":"pntd.0014105.ref006","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1128\/iai.58.7.2085-2090.1990","article-title":"Cryptococcus neoformans, Candida albicans, and other fungi bind specifically to the glycosphingolipid lactosylceramide (Gal beta 1-4Glc beta 1-1Cer), a possible adhesion receptor for yeasts","volume":"58","author":"V Jimenez-Lucho","year":"1990","journal-title":"Infect Immun"},{"issue":"2","key":"pntd.0014105.ref007","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1172\/JCI118086","article-title":"Murine laminin binds to Histoplasma capsulatum. 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