{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T14:14:18Z","timestamp":1781360058468,"version":"3.54.1"},"reference-count":16,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Chikungunya is an arboviral disease characterized by acute osteoarticular manifestations with a risk of progression to chronicity. African data on post-chikungunya chronic arthralgia are scarce. This study aimed to identify factors associated with post-chikungunya chronic arthralgia in Burkina Faso.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>This was a descriptive and analytical cross-sectional study with ambispective data collection, conducted from April 22 to December 28, 2024, at the Medical Center of Pouytenga. All patients aged 16 years and older with RT-PCR- confirmed chikungunya virus infection were included. The evaluation comprised an initial clinical phase and telephone follow-up at 6 months of evolution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We enrolled 174 patients, of whom 111 met the inclusion criteria. The mean age was 31.18 years\u2009\u00b1\u200911.27 years with a female predominance of 66.67% (n\u2009=\u200974). Initial osteoarticular manifestations affected 92.79% of patients (n\u2009=\u2009103), predominantly inflammatory arthralgia in 92.23% (n\u2009=\u200995) and symmetric polyarticular involvement in 73.79% (n\u2009=\u200976). At 6 months of evolution, 28.16% (n\u2009=\u200929) of patients had post-chikungunya chronic arthralgia, with persistence in the ankles in 65.52% of cases (n\u2009=\u200919). Multivariate analysis identified two significantly associated risk factors for chronic arthralgia were age greater than 31 years (OR = 6.22; 95% CI [2.35\u201316.47]; p\u2009&lt;\u20090.001) and dengue coinfection (OR = 18.67; 95% CI [1.74\u2013199.70]; p\u2009=\u20090.016]; p\u2009=\u20090.024).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study found that 28.16% of patients develop post-chikungunya chronic arthralgia at 6 months post infection. Age above 31 years was demonstrated to be a significant predictor of disease chronicity, while the potential role of dengue co-infection, observed in only 4 patients with wide confidence intervals, requires further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0014251","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:48:19Z","timestamp":1777052899000},"page":"e0014251","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Post-chikungunya chronic arthralgia in Burkina Faso: Frequency and associated factors"],"prefix":"10.1371","volume":"20","author":[{"given":"Fulgence","family":"Kabor\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendpanga Jean Emmanuel","family":"Savadogo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9095-8948","authenticated-orcid":true,"given":"Yannick Laurent Tchenadoyo","family":"Bayala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Sompougdou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Sougu\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aboubakar","family":"Ouedraogo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamyell\u00e9 Enselme","family":"Zongo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendlassida Joelle St\u00e9phanie","family":"Zabsonr\u00e9\/ Tiendr\u00e9beogo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieu-Donn\u00e9","family":"Ou\u00e9draogo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"issue":"1","key":"pntd.0014251.ref001","doi-asserted-by":"crossref","first-page":"2396484","DOI":"10.1080\/21505594.2024.2396484","article-title":"Pathogenicity and virulence of chikungunya virus","volume":"15","author":"W Freppel","year":"2024","journal-title":"Virulence"},{"issue":"7","key":"pntd.0014251.ref002","article-title":"Dengue, chikungunya, and zika: the causes and threats of emerging and re-emerging arboviral diseases","volume":"15","author":"S Soni","year":"2023","journal-title":"Cureus"},{"issue":"2","key":"pntd.0014251.ref003","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/infdis\/jiac246","article-title":"Seroepidemiological reconstruction of long-term chikungunya virus circulation in burkina faso and gabon","volume":"227","author":"JK Lim","year":"2023","journal-title":"J Infect Dis"},{"issue":"2","key":"pntd.0014251.ref004","first-page":"54","article-title":"Chikungunya fever and rheumatoid arthritis: a systematic review and meta-analysis","volume":"10","author":"JK Amaral","year":"2025","journal-title":"Trop Med Infect Dis"},{"issue":"2","key":"pntd.0014251.ref005","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jbspin.2017.01.014","article-title":"Rheumatic manifestations associated with Chikungunya virus infection: a study of 307 patients with 32-month follow-up (RHUMATOCHIK study)","volume":"85","author":"E Bouquillard","year":"2018","journal-title":"Joint Bone Spine"},{"issue":"4","key":"pntd.0014251.ref006","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0249867","article-title":"Rheumatic manifestations of Chikungunya virus infection: prevalence, patterns, and enthesitis","volume":"16","author":"S Benjamanukul","year":"2021","journal-title":"PLoS One"},{"issue":"8","key":"pntd.0014251.ref007","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003066","article-title":"Seroprevalence and risk factors of chikungunya virus infection in Mayotte, Indian Ocean, 2005-2006: a population-based survey","volume":"3","author":"D Sissoko","year":"2008","journal-title":"PLoS One"},{"issue":"2","key":"pntd.0014251.ref008","doi-asserted-by":"crossref","first-page":"440","DOI":"10.3899\/jrheum.141609","article-title":"Disability with persistent pain following an epidemic of chikungunya in rural south India","volume":"43","author":"AA Rahim","year":"2016","journal-title":"J Rheumatol"},{"issue":"5","key":"pntd.0014251.ref009","doi-asserted-by":"crossref","first-page":"914","DOI":"10.3390\/idr16050073","article-title":"Chikungunya-driven gene expression linked to osteoclast survival and chronic arthralgia","volume":"16","author":"AH Urbanski","year":"2024","journal-title":"Infect Dis Rep"},{"key":"pntd.0014251.ref010","article-title":"Viral arthritis.","volume-title":"StatPearls","author":"V Tiwari","year":"2025"},{"issue":"1","key":"pntd.0014251.ref011","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0279970","article-title":"Development and validation of a clinical rule for the diagnosis of chikungunya fever in a dengue-endemic area","volume":"18","author":"RP Batista","year":"2023","journal-title":"PloS One"},{"issue":"4","key":"pntd.0014251.ref012","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0196630","article-title":"Chikungunya virus infection in Aruba: diagnosis, clinical features and predictors of post-chikungunya chronic polyarthralgia","volume":"13","author":"R Huits","year":"2018","journal-title":"PLoS One"},{"issue":"4","key":"pntd.0014251.ref013","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02656-24","article-title":"The role of autoantibodies in post-chikungunya viral arthritis disease severity","volume":"13","author":"S Ansah-Dico","year":"2025","journal-title":"Microbiol Spectr"},{"issue":"2","key":"pntd.0014251.ref014","doi-asserted-by":"crossref","DOI":"10.1093\/infdis\/jiaf232","article-title":"Use of recombinant chikungunya virus expressing nanoluciferase to identify chondrocytes as target cells in an immunocompetent mouse model","volume":"232","author":"V Legros","year":"2025","journal-title":"J Infect Dis"},{"key":"pntd.0014251.ref015","doi-asserted-by":"crossref","first-page":"102534","DOI":"10.1016\/j.tmaid.2022.102534","article-title":"Pathogenesis of chronic chikungunya arthritis: resemblances and links with rheumatoid arthritis","volume":"52","author":"JK Amaral","year":"2023","journal-title":"Travel Med Infect Dis"},{"key":"pntd.0014251.ref016","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.imlet.2020.09.005","article-title":"How NETosis could drive \u201cPost-COVID-19 syndrome\u201d among survivors","volume":"228","author":"SA Sawadogo","year":"2020","journal-title":"Immunol Lett"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0014251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:48:22Z","timestamp":1777052902000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0014251"}},"subtitle":[],"editor":[{"given":"Richard A.","family":"Bowen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,4,24]]},"references-count":16,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0014251","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,24]]}}}