{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T18:10:16Z","timestamp":1779214216935,"version":"3.51.4"},"update-to":[{"DOI":"10.1371\/journal.pntd.0014337","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000}}],"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Youth Beijing Scholars Program","award":["087"],"award-info":[{"award-number":["087"]}]},{"name":"Project of Medical Science Research of Hebei Province","award":["20231240"],"award-info":[{"award-number":["20231240"]}]},{"name":"Project of Medical Science Research of Hebei Province","award":["20241280"],"award-info":[{"award-number":["20241280"]}]},{"name":"National Science and Technology Major Project of China","award":["2018ZX10713-001-002"],"award-info":[{"award-number":["2018ZX10713-001-002"]}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Plague is a severe zoonotic disease caused by\n                      <jats:italic>Yersinia pestis<\/jats:italic>\n                      , a pathogen characterized by high infectivity and mortality rates. Historically, three global pandemics have inflicted heavy disasters on human society. Despite improvements in control measures and the application of antibiotics, plague has been somewhat controlled; however, since the beginning of the 21st century, plague outbreaks have continued to occur in regions with a high burden of neglected tropical diseases (NTDs) in Africa, the Americas, and Asia. In recent years, the rapid development of technologies such as molecular biology, immunology, and bioinformatics has propelled significant advancements in plague diagnostics, vaccine development, and transmission mechanisms. However, there has been a lack of systematic quantitative analysis of the distribution characteristics, evolving hotspots, and frontier trends of plague research, which makes it challenging to provide comprehensive scientific support for research and control decision-making.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Search for relevant literatures on plague that were published in the Web of Science Core Collection and PubMed database from January 1, 2016 to November 12, 2025.Bibliometric methods were adopted, and software including COOC 20.6, VOSviewer 1.6.20, and Anaconda were used to analyze the publication trend, distribution of institutions, national cooperation network, keyword co-occurrence clustering, and the annual variation trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1994 documents were finally included. The annual number of publications showed an overall fluctuating upward trend, with a significant growth rate from 2020 to 2021 (annual growth rate of 10.44%). Core research institutions included the U. S. Centers for Disease Control and Prevention and Beijing Institute of Microbiology and Epidemiology. The United States, China, France and Madagascar were the main core countries for cooperation. Keyword co-occurrence clustering identified five major research fields, which were plague vaccine development and immune mechanism, ecology and vector control, historical epidemiology and public health, epidemiology and transmission chain, and plague-related infectious diseases and biosafety. The research trends analysis showed that from 2016 to 2020, the plague research mainly focused on keywords such as \u201cRodents\u201d \u201cEpidemiological Survey\u201d \u201cHuman Plague\u201d and \u201cFleas\u201d. From 2021 to 2025, \u201cPhylogenetic Analysis,\u201d \u201cPublic Health,\u201d and \u201cMadagascar\u201d newly entered the top 20 keyword list; the frequencies of \u201cBlack Death\u201d and \u201cInfectious Disease\u201d increased significantly, while the frequencies of \u201cPlague Vaccine\u201d and \u201cPrairie Dogs\u201d remained relatively stable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Over the past decade, remarkable achievements have been made in plague research. Interdisciplinary integration and technological innovation have continued to deepen. However, global collaboration remains insufficiently developed. In the future, it is necessary to foster broader cross-regional cooperation, accelerate the research, development and translation of vaccines and diagnostic technologies, integrate multiple technologies to construct a precise prevention and control system. and enhance the global collaborative prevention and control capabilities of plague.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0014337","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:46:09Z","timestamp":1778694369000},"page":"e0014337","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evolutionary trends of plague research from 2016 to 2025: A bibliometric analysis"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0401-8286","authenticated-orcid":true,"given":"Yanfen","family":"Niu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuming","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoyi","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1938-9365","authenticated-orcid":true,"given":"Jue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"pntd.0014337.ref001","volume-title":"Manual for plague surveillance, diagnosis, prevention and control","author":"World Health Organization","year":"2024"},{"issue":"5","key":"pntd.0014337.ref002","doi-asserted-by":"crossref","first-page":"985","DOI":"10.4269\/ajtmh.23-0331","article-title":"Plague Gives Surprises in the Second Decade of the Twenty-First Century","volume":"109","author":"T Butler","year":"2023","journal-title":"Am J Trop Med Hyg"},{"issue":"5","key":"pntd.0014337.ref003","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.3934\/mbe.2020244","article-title":"Reconsideration of the plague transmission in perspective of multi-host zoonotic disease model with interspecific interaction","volume":"17","author":"FY Chen","year":"2020","journal-title":"Math Biosci Eng"},{"issue":"10","key":"pntd.0014337.ref004","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004137","article-title":"Infectiousness of Sylvatic and Synanthropic Small Rodents Implicates a Multi-host Reservoir of Leishmania (Viannia) braziliensis","volume":"9","author":"MS Andrade","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"pntd.0014337.ref005","first-page":"19","article-title":"Trypanosomiasis in rodents from selected plague endemic foci of Tanzania","volume":"6","author":"AE Materu","year":"2023","journal-title":"South Asian Journal of Parasitology"},{"issue":"6","key":"pntd.0014337.ref006","article-title":"Epidemiology of leptospira transmitted by rodents in southeast Asia","volume":"8","author":"J-F Cosson","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"pntd.0014337.ref007","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/s42003-022-03240-z","article-title":"Sand flies: Basic information on the vectors of leishmaniasis and their interactions with Leishmania parasites","volume":"5","author":"P Cec\u00edlio","year":"2022","journal-title":"Commun Biol"},{"key":"pntd.0014337.ref008","unstructured":"Centers for Disease Control and Prevention. Chagas Disease: What U.S. Clinicians Need to Know. https:\/\/www.cdc.gov\/parasites\/cme\/chagas\/lesson_1\/3.html"},{"issue":"9","key":"pntd.0014337.ref009","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000300","article-title":"The neglected tropical diseases of Latin America and the Caribbean: a review of disease burden and distribution and a roadmap for control and elimination","volume":"2","author":"PJ Hotez","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"issue":"45","key":"pntd.0014337.ref010","doi-asserted-by":"crossref","first-page":"42014","DOI":"10.1021\/acsomega.3c04587","article-title":"Nanotechnology-Based Strategies in Parasitic Disease Management: From Prevention to Diagnosis and Treatment","volume":"8","author":"R Tiwari","year":"2023","journal-title":"ACS Omega"},{"issue":"1","key":"pntd.0014337.ref011","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1186\/s12889-025-23802-0","article-title":"Public health surveillance of tropical diseases in Madagascar: a scoping review of population burden, intervention strategies, and health system responses","volume":"25","author":"MJN Rajaofera","year":"2025","journal-title":"BMC Public Health"},{"key":"pntd.0014337.ref012","unstructured":"World Health Organization. Country disease outlook: Madagascar (August 2023). https:\/\/www.afro.who.int\/sites\/default\/files\/2023-08\/Madagascar.pdf"},{"issue":"1","key":"pntd.0014337.ref013","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00044-19","article-title":"Yersinia pestis: the natural history of plague","volume":"34","author":"R Barbieri","year":"2020","journal-title":"Clin Microbiol Rev"},{"key":"pntd.0014337.ref014","doi-asserted-by":"crossref","first-page":"40022","DOI":"10.1038\/srep40022","article-title":"Yersinia pestis halotolerance illuminates plague reservoirs","volume":"7","author":"MA Malek","year":"2017","journal-title":"Sci Rep"},{"key":"pntd.0014337.ref015","unstructured":"World Health Organization. Chagas disease (also known as American trypanosomiasis. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/chagas-disease-(american-trypanosomiasis"},{"issue":"7","key":"pntd.0014337.ref016","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1590\/0074-0276140236","article-title":"Ecoepidemiology, short history and control of Chagas disease in the endemic countries and the new challenge for non-endemic countries","volume":"109","author":"JR Coura","year":"2014","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"8","key":"pntd.0014337.ref017","doi-asserted-by":"crossref","first-page":"939","DOI":"10.2174\/0115665240321812240918095931","article-title":"Multiplex PCR System for the Diagnosis of Plague","volume":"25","author":"W Wang","year":"2025","journal-title":"Current Molecular Medicine"},{"issue":"5","key":"pntd.0014337.ref018","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0012167","article-title":"Development and evaluation of a multi-target droplet digital PCR assay for highly sensitive and specific detection of Yersinia pestis","volume":"18","author":"Y Zhao","year":"2024","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0014337.ref019","doi-asserted-by":"crossref","first-page":"149324","DOI":"10.1016\/j.ijbiomac.2025.149324","article-title":"Development of a rapid and sensitive one-pot recombinase polymerase amplification assay for the simultaneous detection of Bacillus anthracis and Yersinia pestis with naked eye result read-out","volume":"335","author":"M Paul","year":"2026","journal-title":"Int J Biol Macromol"},{"issue":"10","key":"pntd.0014337.ref020","article-title":"A single-dose F1-based mRNA-LNP vaccine provides protection against the lethal plague bacterium","volume":"9","author":"E Kon","year":"2023","journal-title":"Sci Adv"},{"key":"pntd.0014337.ref021","doi-asserted-by":"crossref","first-page":"1603710","DOI":"10.3389\/fimmu.2025.1603710","article-title":"Nanolipoprotein particle (NLP) vaccine confers protection against Yersinia pestis aerosol challenge in a BALB\/c mouse model","volume":"16","author":"SS Biryukov","year":"2025","journal-title":"Frontiers in Immunology"},{"key":"pntd.0014337.ref022","doi-asserted-by":"crossref","first-page":"726416","DOI":"10.3389\/fimmu.2021.726416","article-title":"Impact of Toll-Like Receptor-Specific Agonists on the Host Immune Response to the Yersinia pestis Plague rF1V Vaccine","volume":"12","author":"S Biryukov","year":"2021","journal-title":"Front Immunol"},{"issue":"6","key":"pntd.0014337.ref023","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.03223-21","article-title":"Combinatorial Viral Vector-Based and Live Attenuated Vaccines without an Adjuvant to Generate Broader Immune Responses to Effectively Combat Pneumonic Plague","volume":"12","author":"PB Kilgore","year":"2021","journal-title":"mBio"},{"issue":"5","key":"pntd.0014337.ref024","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0010362","article-title":"Phylogenetic analysis of the origin and spread of plague in Madagascar","volume":"17","author":"LR Esquivel Gomez","year":"2023","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0014337.ref025","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ijid.2018.11.203","article-title":"Whole-genome SNP-based phylogenetic analysis of Yersinia pestis isolates from Georgia and neighboring Caucasian countries","volume":"79","author":"E Zhgenti","year":"2019","journal-title":"International Journal of Infectious Diseases"},{"issue":"3","key":"pntd.0014337.ref026","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/gcb.15966","article-title":"Plague risk in the western United States over seven decades of environmental change","volume":"28","author":"CJ Carlson","year":"2022","journal-title":"Glob Chang Biol"},{"issue":"17","key":"pntd.0014337.ref027","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.3390\/ani13172736","article-title":"Himalayan Marmot (Marmota himalayana) Redistribution to High Latitudes under Climate Change","volume":"13","author":"Z Wang","year":"2023","journal-title":"Animals (Basel)"},{"key":"pntd.0014337.ref028","doi-asserted-by":"crossref","first-page":"1541792","DOI":"10.3389\/fmicb.2025.1541792","article-title":"Research hotspots and development trends of Brucellar spondylitis in the past 30\u00a0years: a bibliometric analysis","volume":"16","author":"J Wu","year":"2025","journal-title":"Front Microbiol"},{"issue":"9","key":"pntd.0014337.ref029","article-title":"Mapping research trends in one health: a comprehensive review","volume":"16","author":"R Raphael","year":"2024","journal-title":"Cureus"},{"issue":"8","key":"pntd.0014337.ref030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0008251","article-title":"Human plague: An old scourge that needs new answers","volume":"14","author":"X Vall\u00e8s","year":"2020","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0014337.ref031","unstructured":"Academic Drip, Bibliometrics. COOC: A software for bibliometrics and knowledge graph visualization. https:\/\/gitee.com\/academic_2088904822\/academic-drip"},{"issue":"8","key":"pntd.0014337.ref032","first-page":"1286","article-title":"Emerging and Re-emerging Infectious Diseases in the WHO Eastern Mediterranean Region, 2001-2018","volume":"11","author":"E Mostafavi","year":"2022","journal-title":"Int J Health Policy Manag"},{"issue":"11","key":"pntd.0014337.ref033","first-page":"1628","article-title":"Climate Change Drives the Transmission and Spread of Vector-Borne Diseases: An Ecological Perspective","volume":"11","author":"J Ma","year":"2022","journal-title":"Biology (Basel)"},{"issue":"3","key":"pntd.0014337.ref034","article-title":"A novel sORF gene mutant strain of Yersinia pestis vaccine EV76 offers enhanced safety and improved protection against plague","volume":"20","author":"X Guo","year":"2024","journal-title":"PLoS Pathog"},{"issue":"1","key":"pntd.0014337.ref035","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/s13104-025-07315-y","article-title":"IgG antibodies anti-LcrV of Yersinia pestis: inconsistent responses in confirmed plague patients from Madagascar","volume":"18","author":"OH Andriatefy","year":"2025","journal-title":"BMC Res Notes"},{"issue":"5","key":"pntd.0014337.ref036","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0013054","article-title":"Opportunities and challenges for plague vector control in Madagascar","volume":"19","author":"AO Raveloson","year":"2025","journal-title":"PLoS Negl Trop Dis"},{"issue":"5","key":"pntd.0014337.ref037","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1590\/S0036-46652014000500003","article-title":"South American collaboration in scientific publications on leishmaniasis: bibliometric analysis in SCOPUS (2000-2011)","volume":"56","author":"C Huaman\u00ed","year":"2014","journal-title":"Rev Inst Med Trop Sao Paulo"},{"issue":"6","key":"pntd.0014337.ref038","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1056\/NEJMoa2413772","article-title":"Ciprofloxacin versus Aminoglycoside-Ciprofloxacin for Bubonic Plague","volume":"393","author":"RV Randremanana","year":"2025","journal-title":"N Engl J Med"},{"key":"pntd.0014337.ref039","doi-asserted-by":"crossref","first-page":"793382","DOI":"10.3389\/fimmu.2022.793382","article-title":"Complete Protection Against Yersinia pestis in BALB\/c Mouse Model Elicited by Immunization With Inhalable Formulations of rF1-V10 Fusion Protein via Aerosolized Intratracheal Inoculation","volume":"13","author":"W Zhang","year":"2022","journal-title":"Front Immunol"},{"issue":"8","key":"pntd.0014337.ref040","doi-asserted-by":"crossref","DOI":"10.1128\/iai.00165-22","article-title":"Protection Induced by Oral Vaccination with a Recombinant Yersinia pseudotuberculosis Delivering Yersinia pestis LcrV and F1 Antigens in Mice and Rats against Pneumonic Plague","volume":"90","author":"S Majumder","year":"2022","journal-title":"Infect Immun"},{"issue":"2","key":"pntd.0014337.ref041","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3390\/hygiene5020018","article-title":"Global Trends and Action Items for the Prevention and Control of Emerging and Re-Emerging Infectious Diseases","volume":"5","author":"S De Gaetano","year":"2025","journal-title":"Hygiene"},{"issue":"11","key":"pntd.0014337.ref042","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3390\/bioengineering8110155","article-title":"Novel Vaccine Adjuvants as Key Tools for Improving Pandemic Preparedness","volume":"8","author":"BH Pogostin","year":"2021","journal-title":"Bioengineering (Basel)"},{"key":"pntd.0014337.ref043","doi-asserted-by":"crossref","first-page":"100893","DOI":"10.1016\/j.ijppaw.2023.12.001","article-title":"Prairie dog responses to vector control and vaccination during an initial Yersinia pestis invasion","volume":"23","author":"DA Eads","year":"2023","journal-title":"Int J Parasitol Parasites Wildl"},{"issue":"2","key":"pntd.0014337.ref044","first-page":"434","article-title":"Fipronil Pellets Reduce Flea Abundance on Black-Tailed Prairie Dogs: Potential Tool for Plague Management and Black-Footed Ferret Conservation","volume":"57","author":"DA Eads","year":"2021","journal-title":"J Wildl Dis"},{"key":"pntd.0014337.ref045","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.actatropica.2018.07.029","article-title":"Risk of maritime introduction of plague from Madagascar to Mayotte","volume":"187","author":"S Rahelinirina","year":"2018","journal-title":"Acta Trop"},{"issue":"1","key":"pntd.0014337.ref046","first-page":"84","article-title":"Lethal effects on flea larvae of fipronil in host feces: potential benefits for plague mitigation","volume":"59","author":"DA Eads","year":"2023","journal-title":"J Wildl Dis"},{"issue":"2","key":"pntd.0014337.ref047","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3201\/eid3002.230759","article-title":"Multiple Introductions of Yersinia pestis during Urban Pneumonic Plague Epidemic, Madagascar, 2017","volume":"30","author":"V Andrianaivoarimanana","year":"2024","journal-title":"Emerging infectious diseases"},{"issue":"3","key":"pntd.0014337.ref048","doi-asserted-by":"crossref","DOI":"10.1128\/aac.01497-24","article-title":"Assessing the threat of Yersinia pestis harboring a multi-resistant IncC plasmid and the efficacy of an antibiotic targeting LpxC","volume":"69","author":"N Lemaitre","year":"2025","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"pntd.0014337.ref049","doi-asserted-by":"crossref","first-page":"14628","DOI":"10.1038\/s41598-020-71530-9","article-title":"Yersinia pestis strains from Latvia show depletion of the pla virulence gene at the end of the second plague pandemic","volume":"10","author":"J Susat","year":"2020","journal-title":"Sci Rep"},{"key":"pntd.0014337.ref050","doi-asserted-by":"crossref","first-page":"105081","DOI":"10.1016\/j.meegid.2021.105081","article-title":"Differential mortality of infectious disease in Italian polities: COVID-19, past plague epidemics, and currently endemic respiratory disease","volume":"95","author":"J Jurgensen","year":"2021","journal-title":"Infect Genet Evol"},{"issue":"4","key":"pntd.0014337.ref051","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.bsheal.2020.08.001","article-title":"Tackling COVID-19: Insights from the Qinghai Province plague prevention and control (PPC) model","volume":"2","author":"H Wu","year":"2020","journal-title":"Biosafety and Health"},{"key":"pntd.0014337.ref052","doi-asserted-by":"crossref","first-page":"630449","DOI":"10.3389\/fpubh.2021.630449","article-title":"Societal Impacts of Pandemics: Comparing COVID-19 With History to Focus Our Response","volume":"9","author":"GE Patterson","year":"2021","journal-title":"Front Public Health"},{"issue":"6","key":"pntd.0014337.ref053","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0012252","article-title":"Review of genotyping methods for Yersinia pestis in Madagascar","volume":"18","author":"LN Randriantseheno","year":"2024","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"pntd.0014337.ref054","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1186\/s12917-025-04884-9","article-title":"Plague and tularemia surveillance in hormozgan province, Southern Iran","volume":"21","author":"HA Cohan","year":"2025","journal-title":"BMC Vet Res"},{"issue":"5","key":"pntd.0014337.ref055","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.00036-19","article-title":"Multiplex Detection of Three Select Agents Directly from Blood by Use of the GeneXpert System","volume":"57","author":"PP Banada","year":"2019","journal-title":"J Clin Microbiol"},{"issue":"1","key":"pntd.0014337.ref056","doi-asserted-by":"crossref","first-page":"7009","DOI":"10.1038\/s41598-018-24581-y","article-title":"Single vector platform vaccine protects against lethal respiratory challenge with Tier 1 select agents of anthrax, plague, and tularemia","volume":"8","author":"Q Jia","year":"2018","journal-title":"Sci Rep"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0014337","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0014337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:39:13Z","timestamp":1779212353000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0014337"}},"subtitle":[],"editor":[{"given":"Vladimir L.","family":"Motin","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,5,13]]},"references-count":56,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0014337","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,13]]}}}