{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:48:43Z","timestamp":1792788523499,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0014367","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000}}],"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto Nacional de Perinatolog\u00eda","award":["2017-3-116"],"award-info":[{"award-number":["2017-3-116"]}],"id":[{"id":"https:\/\/ror.org\/00ctdh943","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Indiana University President\u2019s International Research Award","award":["PSA-PRO-0680-2020; PIRA10302019"],"award-info":[{"award-number":["PSA-PRO-0680-2020; PIRA10302019"]}],"id":[{"id":"https:\/\/ror.org\/01kg8sb98","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Indiana University President\u2019s International Research Award","award":["PSA-PRO-0680-2020; PIRA10302019"],"award-info":[{"award-number":["PSA-PRO-0680-2020; PIRA10302019"]}],"id":[{"id":"https:\/\/ror.org\/01kg8sb98","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008140","name":"Pritzker School of Medicine","doi-asserted-by":"publisher","award":["Pritzker Fellowship"],"award-info":[{"award-number":["Pritzker Fellowship"]}],"id":[{"id":"10.13039\/100008140","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001949","name":"American Society of Tropical Medicine and Hygiene","doi-asserted-by":"publisher","award":["Benjamin H. Kean Travel Fellowship"],"award-info":[{"award-number":["Benjamin H. Kean Travel Fellowship"]}],"id":[{"id":"10.13039\/100001949","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Women living in leishmaniasis-endemic zones are regularly exposed to the sandfly vector in their environments. While case series and laboratory evidence consistently suggest transplacental transmission of\n                      <jats:italic>Leishmania<\/jats:italic>\n                      parasites with deleterious maternal-fetal effects, this issue has received insufficient attention, particularly in areas where the predominant\n                      <jats:italic>Leishmania<\/jats:italic>\n                      species is mainly associated with cutaneous disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methodology\/principal findings<\/jats:title>\n                    <jats:p>\n                      We conducted an exploratory cross-sectional study in a highly endemic zone of Tabasco, Mexico, enrolling 53 women with singleton term deliveries between April 2018 and April 2020. Placental PCR was positive in 18 (34%) participants. Buccal swabs were positive in 11 (21.2%) of 52 newborns. Immunofluorescence confirmed intracellular amastigotes within macrophages near the vascular endothelium of PCR-positive placentas, with no surrounding inflammatory infiltration. Sequencing revealed homology to\n                      <jats:italic>Leishmania mexicana<\/jats:italic>\n                      ,\n                      <jats:italic>L. amazonensis<\/jats:italic>\n                      , or\n                      <jats:italic>L. panamensis<\/jats:italic>\n                      . Birthweight percentile was modestly lower in the PCR-positive group (predicted mean 53.8% vs. 56.5%, p\u2009=\u20090.76), while small for gestational age showed a non-significant trend toward higher prevalence among PCR-positive cases (prevalence ratio\u2009=\u20092.06, 95% CI: 0.32\u201313.39, p\u2009=\u20090.45).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Conclusions\/significance<\/jats:title>\n                    <jats:p>\n                      Subclinical, dynamic transmission of\n                      <jats:italic>Leishmania<\/jats:italic>\n                      parasites typically associated with cutaneous disease was detected in this endemic zone. The presence of\n                      <jats:italic>L. mexicana<\/jats:italic>\n                      in human placentas was confirmed by immunofluorescence and sequencing, without an associated inflammatory response. These findings highlight the potential of CL-associated\n                      <jats:italic>Leishmania<\/jats:italic>\n                      species to reach the placenta and buccal mucosa of newborns, warranting further epidemiological investigation into the consequences of vertical transmission in regions with endemic CL.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0014367","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:16:07Z","timestamp":1789496167000},"page":"e0014367","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Placentas from healthy women living in a cutaneous leishmaniasis endemic region in Mexico harbor Leishmania mexicana parasites: Potential implications for pregnancy and neonatal outcomes"],"prefix":"10.1371","volume":"20","author":[{"given":"Rodrigo X.","family":"Armijos","sequence":"first","affiliation":[{"name":"Indiana University-Bloomington School of Public Health","place":["Bloomington, Indiana, United States of America"],"department":["Global Environmental Health Laboratory, Department of Environmental & Occupational Health"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon A.","family":"Berger","sequence":"additional","affiliation":[{"name":"Pritzker School of Medicine, University of Chicago","place":["Chicago, Illinois, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Gonz\u00e1lez Ayala","sequence":"additional","affiliation":[{"name":"Maestr\u00eda en Investigaci\u00f3n Cl\u00ednica, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional","place":["Ciudad de M\u00e9xico, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam A.","family":"Delgado-Hernandez","sequence":"additional","affiliation":[{"name":"Maestr\u00eda en Investigaci\u00f3n Cl\u00ednica, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional","place":["Ciudad de M\u00e9xico, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Acosta-Pati\u00f1o","sequence":"additional","affiliation":[{"name":"Universidad Ju\u00e1rez Aut\u00f3noma de Tabasco","place":["Villahermosa, Tabasco, Mexico"],"department":["Divisi\u00f3n Acad\u00e9mica de Ciencias de la Salud"]},{"name":"Secretar\u00eda de Salud de Tabasco","place":["Cunduac\u00e1n, Tabasco, Mexico"],"department":["Jurisdicci\u00f3n Cunduac\u00e1n"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esmelin","family":"Trinidad-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Universidad Ju\u00e1rez Aut\u00f3noma de Tabasco","place":["Villahermosa, Tabasco, Mexico"],"department":["Divisi\u00f3n Acad\u00e9mica de Ciencias de la Salud"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana Aline","family":"Fern\u00e1ndez-Urrutia","sequence":"additional","affiliation":[{"name":"Saint Luke School of Medicine, Alliant International University","place":["Ciudad de M\u00e9xico, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Baz-Rojas","sequence":"additional","affiliation":[{"name":"Secretar\u00eda de Salud de Tabasco","place":["Cunduac\u00e1n, Tabasco, Mexico"],"department":["Jurisdicci\u00f3n Cunduac\u00e1n"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0718-467X","authenticated-orcid":true,"given":"Javier","family":"Mancilla-Galindo","sequence":"additional","affiliation":[{"name":"Institute for Risk Assessment Sciences, Utrecht University","place":["Utrecht, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candelaria","family":"Fr\u00edas Selv\u00e1n","sequence":"additional","affiliation":[{"name":"Secretar\u00eda de Salud de Tabasco","place":["Cunduac\u00e1n, Tabasco, Mexico"],"department":["Hospital Regional de Cunduac\u00e1n"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juana","family":"Ort\u00edz-Avalos","sequence":"additional","affiliation":[{"name":"CETis No. 70, SEP","place":["Villahermosa, Tabasco, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Cristina","family":"Avalos-Ortiz","sequence":"additional","affiliation":[{"name":"Hospital Regional de Alta Especialidad Dr. Gustavo A. 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