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In response, various innovative technologies and interventions, including biocontrol strategies that deploy\n                      <jats:italic>Wolbachia<\/jats:italic>\n                      -infected mosquitoes, are being explored. These can be used to either replace the existing mosquito population with one that is less likely to transmit infection or to suppress the existing mosquito population. We conducted a scoping review of economic evaluations of\n                      <jats:italic>Wolbachia-<\/jats:italic>\n                      based interventions for dengue control, aimed at summarising assumptions and results of existing studies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methodology\/Principal Findings<\/jats:title>\n                    <jats:p>\n                      A scoping review of the published literature was conducted on the 29\n                      <jats:sup>th<\/jats:sup>\n                      of April 2024 using the MEDLINE (via OVID), Embase Classic+Embase (via OVID), Global Health - OVID, PubMed, and Econ Lit electronic databases. No date or language restrictions were applied to the searches. We identified nine studies that reported the results of economic evaluations of\n                      <jats:italic>Wolbachia-<\/jats:italic>\n                      based interventions for dengue control. The majority (eight out of nine studies) investigated\n                      <jats:italic>Wolbachia<\/jats:italic>\n                      replacement-based programmes. Overall, the results were supportive for the use of replacement-based programmes in large urban settings, with the intervention likely to generate cost savings from a societal perspective.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Conclusions\/Significance.<\/jats:title>\n                    <jats:p>\n                      The available economic evaluations consistently suggest that\n                      <jats:italic>Wolbachia<\/jats:italic>\n                      -based replacement interventions can be cost-effective for dengue control when targeted to densely populated urban areas, and several studies indicate that they can generate substantial long\u2011term cost savings from a societal perspective. Further research is needed to understand how heterogeneity in epidemiological effectiveness influences long-term projected cost\u2011effectiveness and to investigate the combination of\n                      <jats:italic>Wolbachia-<\/jats:italic>\n                      based interventions with other dengue control\/prevention measures (such as vaccination). To support more robust and comparable analyses, we provide recommendations for future studies in this area, emphasising the importance of reporting results disaggregated by cost and outcome components, and making important underlying assumptions related to the intervention more explicit.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0014395","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T17:57:25Z","timestamp":1780336645000},"page":"e0014395","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["The cost-effectiveness of Wolbachia-based biocontrol interventions for dengue: A scoping review of the available evidence"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8428-3874","authenticated-orcid":true,"given":"Hugo C.","family":"Turner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trinh Manh","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver J.","family":"Brady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raman","family":"Velayudhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Dorigatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah E.","family":"Clapham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"pntd.0014395.ref001","unstructured":"World Health Organization. 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