{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T01:48:03Z","timestamp":1785203283271,"version":"3.55.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0014403","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000}}],"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R56 AI155573-01A1"],"award-info":[{"award-number":["R56 AI155573-01A1"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>\n                    The mosquito\n                    <jats:italic>Aedes aegypti<\/jats:italic>\n                    is the primary vector of dengue virus, and the release of mosquitoes infected with the bacterium\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    is an increasingly used strategy to reduce dengue transmission. This approach relies on\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    \u2019s ability to suppress virus replication within the mosquito, but the effectiveness of virus suppression and the associated fitness costs may depend on interactions among mosquito genetic background,\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    strain, and dengue virus type. Here, we examined these interactions using mosquito populations from Brazil, Paraguay, and Peru infected with two\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    strains,\n                    <jats:italic>w<\/jats:italic>\n                    MelM and\n                    <jats:italic>w<\/jats:italic>\n                    AlbB, and exposed to dengue virus serotype 1 or serotype 2. We measured dengue virus infection in transmission-relevant tissues and quantified mosquito survival, development, and reproduction under controlled laboratory conditions.\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    infection reduced dengue virus infection overall, but the strength of virus suppression varied among mosquito populations, with the strongest blocking observed in Brazilian mosquitoes and the weakest in Peruvian mosquitoes. Across all populations, the\n                    <jats:italic>w<\/jats:italic>\n                    MelM strain consistently produced stronger dengue virus suppression than\n                    <jats:italic>w<\/jats:italic>\n                    AlbB, whereas mosquitoes infected with\n                    <jats:italic>w<\/jats:italic>\n                    AlbB generally exhibited higher fitness, with fitness effects varying among mosquito populations and life-history traits. Together, these results show that genetic interactions among the mosquito,\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    , and dengue virus shape both virus blocking and mosquito fitness, highlighting trade-offs that may influence the establishment and long-term effectiveness of\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    -based dengue control programs.\n                  <\/jats:p>","DOI":"10.1371\/journal.pntd.0014403","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T17:43:23Z","timestamp":1779903803000},"page":"e0014403","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Interactions between mosquito genetic background and Wolbachia strain affect dengue virus blocking and fitness in South American populations of Aedes aegypti"],"prefix":"10.1371","volume":"20","author":[{"given":"Suk 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