{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T17:57:20Z","timestamp":1781546240177,"version":"3.54.5"},"update-to":[{"DOI":"10.1371\/journal.pntd.0014434","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000}}],"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K08A143968"],"award-info":[{"award-number":["K08A143968"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007856","name":"Baylor College of Medicine","doi-asserted-by":"publisher","award":["Bridge-to-Independence Funding"],"award-info":[{"award-number":["Bridge-to-Independence Funding"]}],"id":[{"id":"10.13039\/100007856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"CPRIT","doi-asserted-by":"crossref","award":["Core Facility Support Award RP240432"],"award-info":[{"award-number":["Core Facility Support Award RP240432"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institute of Health","award":["CA125123, OD036336, and OD038251"],"award-info":[{"award-number":["CA125123, OD036336, and OD038251"]}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>\n                    Ascariasis remains a dominant global health burden due to its vast prevalence and associated morbidity. The obligatory migration of\n                    <jats:italic>Ascaris<\/jats:italic>\n                    larvae through pulmonary tissue triggers intense type-2 inflammation which typically presents as acute allergic airway disease. Even after the parasite is eliminated, a single episode of larval migration can result in chronic lung damage and dysfunction, which may be driven by the long-term retention of helminth antigens in macrophages. However, the molecular identity of these retained antigens, and the mechanisms by which they sustain chronic T cell responses, remain unknown. In this study, we utilized immunopeptidomics to identify a retained peptide specific from\n                    <jats:italic>Ascaris<\/jats:italic>\n                    that is sequestered and presented by pulmonary macrophages via MHC-II. We further demonstrated that this retained peptide serves as an epitope which is associated with the development of specific T helper cell populations that persist long after the infection has cleared. These findings define a potential molecular mechanism for persistent helminth-induced immune cell activiation in the lungs and identify a retained epitope as a potential contributor to the development of chronic pulmonary inflammation following parasite elimination from the lungs.\n                  <\/jats:p>","DOI":"10.1371\/journal.pntd.0014434","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T17:37:16Z","timestamp":1781026636000},"page":"e0014434","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of a persistent Ascaris-derived Kalirin epitope associated with chronic T cell activation in the lung"],"prefix":"10.1371","volume":"20","author":[{"given":"Yifan","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leroy","family":"Versteeg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Chih","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8043-3177","authenticated-orcid":true,"given":"Jill E.","family":"Weatherhead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"issue":"1","key":"pntd.0014434.ref001","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1468-0262.2004.00481.x","article-title":"Worms: Identifying Impacts On Education And Health In The Presence Of Treatment Externalities","volume":"72","author":"E Miguel","year":"2004","journal-title":"Econometrica"},{"issue":"4","key":"pntd.0014434.ref002","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0169-4758(99)01634-8","article-title":"Do intestinal nematodes affect productivity in adulthood?","volume":"16","author":"H Guyatt","year":"2000","journal-title":"Parasitology Today"},{"key":"pntd.0014434.ref003","unstructured":"IHME. 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