{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T17:59:49Z","timestamp":1781287189870,"version":"3.54.1"},"update-to":[{"DOI":"10.1371\/journal.pntd.0014435","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000}}],"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Snakebite envenoming (SBE) is a significant yet often overlooked public health crisis that primarily affects impoverished communities. Mobile applications (apps) can be effective tools for managing snakebites. To meet the World Health Organization\u2019s (WHO) goal of reducing SBE by 50% by 2030, app developers must consider regional users\u2019 preferences to ensure their apps provide relevant and accurate information. This study predicted the importance of various functionalities of a mobile app for managing snakebites based on user preferences. Our objective was to provide quantitative evidence on which functions should be prioritized to inform the development of a customized local app to enhance snakebite care in Ghana.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional survey using a quantitative statistical experiment design method was conducted to identify healthcare workers\u2019 preferences for vital mobile app functions for managing snakebites. Participants were selected from two deprived and predominantly rural districts in the Eastern region of Ghana through a multi-stage sampling technique. The attributes used in the questionnaire were developed based on literature reviews and focus group discussions, and a statistical block design was employed to create the choice tasks. To rigorously evaluate the performance of the machine learning (ML) models and reduce the risk of overfitting, we employed 5-fold cross-validation and multiple evaluation metrics. The data were analyzed using seven ML models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The four most vital mobile app functions identified by the participants were \u201cstep-by-step assistance for victims and first responders\u201d (utility estimates (\u03b2) =0.3924; 95% confidence interval (CI): 0.3183 to 0.4665), \u201cproviding educational and training materials\u201d (\u03b2\u2009=\u20090.2243; 95% CI: 0.1500 to 0.2987), \u201cidentifying venomous snakes through clinical evidence or symptoms\u201d (\u03b2\u2009=\u20090.1718; 95% CI: 0.0982 to 0.2454) and \u201cidentifying venomous snake biodiversity in your area\/region\u201d (\u03b2\u2009=\u20090.0898; 95% CI: 0.0176 to 0.1620). Conversely, the app functions that were less favored included \u201cplatform for sharing snakebite treatment experiences\u201d (\u03b2\u2009=\u2009-0.2503; 95% CI: -0.3268 to -0.1738) and \u201cdesigning educational games about snakes\u201d (\u03b2\u2009=\u2009-0.3995; 95% CI: -0.4737 to -0.3252). These findings align with subgroup analyses by gender, suggesting a consistent understanding of needs across different demographic groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides quantitative evidence on which mobile app functions should be prioritized to inform the development of a customized local app to improve management and care for snakebite victims in Ghana and other sub-Saharan African countries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0014435","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T17:47:05Z","timestamp":1780940825000},"page":"e0014435","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictive Modeling of Localized Mobile App to Improve Snakebite Management in Ghana"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1666-7489","authenticated-orcid":true,"given":"Eric","family":"Nyarko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aashna","family":"Uppal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas Amani","family":"Hamman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Agyekum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Antwi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuhu","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Obu-Amoah","family":"Ampomah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iddrisu Abugbil","family":"Atubiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trudie","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"issue":"3","key":"pntd.0014435.ref001","doi-asserted-by":"crossref","DOI":"10.1016\/S2214-109X(22)00029-8","article-title":"Snakebite envenoming: a hidden health crisis","volume":"10","author":"B Basnyat","year":"2022","journal-title":"Lancet Glob Health"},{"issue":"4","key":"pntd.0014435.ref002","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0012080","article-title":"Snakebite envenoming: a systematic review and meta-analysis of global morbidity and mortality","volume":"18","author":"A Afroz","year":"2024","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0014435.ref003","doi-asserted-by":"crossref","first-page":"17063","DOI":"10.1038\/nrdp.2017.63","article-title":"Snakebite envenoming","volume":"3","author":"JM Guti\u00e9rrez","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"pntd.0014435.ref004","article-title":"The WHO strategy for prevention and control of snakebite envenoming: a sub-Saharan Africa plan","volume":"25","author":"J-P Chippaux","year":"2019","journal-title":"J Venom Anim Toxins Incl Trop Dis"},{"issue":"7","key":"pntd.0014435.ref005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0011050","article-title":"Compendium of medically important snakes, venom activity and clinical presentations in Ghana","volume":"17","author":"JP Deikumah","year":"2023","journal-title":"PLoS Negl Trop Dis"},{"issue":"8","key":"pntd.0014435.ref006","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0007221","article-title":"Epidemiology, ecology and human perceptions of snakebites in a savanna community of northern Ghana","volume":"13","author":"Y Musah","year":"2019","journal-title":"PLoS Negl Trop Dis"},{"issue":"4","key":"pntd.0014435.ref007","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/trstmh\/trae113","article-title":"Snakebites, a neglected public health concern: an analysis of distribution, trends and incidence of snakebite cases reported to health facilities in the Volta Region of Ghana, 2018-2023","volume":"119","author":"SA Bosoka","year":"2025","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"pntd.0014435.ref008","volume-title":"World Health Organisation","author":"WHO","year":"2019"},{"key":"pntd.0014435.ref009","doi-asserted-by":"crossref","DOI":"10.2196\/71378","article-title":"Digital health intervention in snakebite management: scoping review","volume":"27","author":"A Dash","year":"2025","journal-title":"J Med Internet Res"},{"key":"pntd.0014435.ref010","unstructured":"Ghana Health Service. 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Ghana Statistical Service [Online]. 2025."},{"key":"pntd.0014435.ref017","unstructured":"NCA. 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[cited 2023 October 1]. https:\/\/www.ghanaweb.com\/GhanaHomePage\/NewsArchive\/Snake-bite-perennial-condition-in-the-Afram-Plains-6972#:~:text=Fri%2C%2028%20May%201999%20Source,districts%20by%20some%20migrant%20farmers"},{"key":"pntd.0014435.ref031","article-title":"Health workforce retention situation and effect on service delivery in three highly deprived districts in Ghana: a mixed methods design","author":"L Baatiema","year":"2025","journal-title":"Research Square"},{"key":"pntd.0014435.ref032","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511610356","volume-title":"Applied choice analysis: a primer","author":"DA Hensher","year":"2005"},{"issue":"7","key":"pntd.0014435.ref033","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0013295","article-title":"Healthcare workers\u2019 priorities of WHO snakebite strategic objectives for the control and prevention of snakebite envenoming in Ghana: a machine learning statistical design of experiment modeling","volume":"19","author":"E Nyarko","year":"2025","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0014435.ref034","article-title":"Predicting challenges and opportunities in improving snakebite envenoming management in Ghana","author":"E Nyarko","year":"2026","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"10","key":"pntd.0014435.ref035","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1080\/02664763.2021.1907840","article-title":"Machine learning and design of experiments with an application to product innovation in the chemical industry","volume":"49","author":"R Arboretti","year":"2021","journal-title":"J Appl Stat"},{"issue":"10","key":"pntd.0014435.ref036","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005079","article-title":"The treatment of snake bites in a first aid setting: a systematic review","volume":"10","author":"B Avau","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0014435.ref037","first-page":"1","article-title":"Mixed reality tool for training on pressure immobilization treatment of snake bite envenomation","author":"S Smilevski","year":"2018","journal-title":"Proceedings of the 23rd International ACM Conference on 3D Web Technology"},{"key":"pntd.0014435.ref038","unstructured":"WHO. 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