{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:28:41Z","timestamp":1792614521512,"version":"4.5.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key R&D Programme of Xinjiang Uygur Autonomous Region","award":["2022B03013-4"],"award-info":[{"award-number":["2022B03013-4"]}]},{"name":"\u201cTianshan Talent\u201d Program for Training High-level Talents in Medicine and Healthcare","award":["TSYC202401B058,"],"award-info":[{"award-number":["TSYC202401B058,"]}]},{"name":"\u201cTianshan Talent\u201d Program for Training High-level Talents in Medicine and Healthcare","award":["TSYC202401B020"],"award-info":[{"award-number":["TSYC202401B020"]}]},{"name":"State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia Fund","award":["SKL-HIDCA-2022-BC3"],"award-info":[{"award-number":["SKL-HIDCA-2022-BC3"]}]},{"name":"2023 Clinical Pharmacy Research Fund of Chinese Society of Clinical Pharmacy, China International Medical Exchange Foundation","award":["Z-2021-46-2101-2023"],"award-info":[{"award-number":["Z-2021-46-2101-2023"]}]},{"name":"Research Fund of Xinjiang Uygur Autonomous Region Pharmaceutical Association","award":["YXH202406"],"award-info":[{"award-number":["YXH202406"]}]},{"name":"Xinjiang Agricultural University Graduate Research and Innovation Fund","award":["XJAUGRI2025043"],"award-info":[{"award-number":["XJAUGRI2025043"]}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>Harmine (HM), a bioactive alkaloid, exhibits remarkable antiparasitic potency. Nevertheless, its translational potential is substantially constrained by neurotoxicity, necessitating the development of safer analogs. H-2-168, a rationally designed derivative synthesized via targeted structural modifications of the HM core, has emerged as a leading candidate for further therapeutic exploration due to its favorable pharmacological profile. To optimize its pharmacokinetic properties and enhance treatment efficacy, this study reports the fabrication of H-2-168-loaded poly (lactic - co - glycolic acid) (PLGA) nanoparticles (H8-PLGA-NPs). Results demonstrated that H8-PLGA-NPs exhibited uniform spherical morphology with an average diameter of 198 nm (PDI\u2009=\u20090.15) and a high drug encapsulation efficiency of 88.6%. Following 30-day oral administration (100 mg\/kg\/day), H8-PLGA-NPs demonstrated significantly enhanced anthelmintic efficacy and tissue regenerative capacity compared to free H-2-168, while effectively ameliorating inflammatory responses and hepatic fibrosis progression. Notably, systemic toxicity was substantially reduced, particularly hepatotoxicity and cytotoxicity. This study substantiates that PLGA-based nanocarriers markedly improve the therapeutic outcomes of H-2-168 against cystic echinococcosis (CE) through optimized drug encapsulation and delivery efficiency, thereby proposing a promising therapeutic strategy for CE management. Nevertheless, comprehensive investigations into the long-term biosafety profiles of these nanoparticles and optimal dosing regimens warrant further exploration.<\/jats:p>","DOI":"10.1371\/journal.pntd.0014483","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T17:38:07Z","timestamp":1784914687000},"page":"e0014483","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["PLGA - encapsulated harmine derivative H-2-168: A promising therapeutic agent for mitigating liver damage in hepatic hydatid 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