{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T18:20:42Z","timestamp":1783707642621,"version":"3.55.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0014488","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000}}],"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Chagas Disease (CD) remains a persistent public health problem in Brazil, particularly in historically hyperendemic regions such as northern Minas Gerais. Despite the sustained burden of transmission and chronic disease, access to specialized care for CD continues to be limited. This study aimed to describe the clinical and epidemiological profile of patients attending a newly established specialized CD outpatient clinic and to contextualize its role within the regional hyperendemic scenario.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A descriptive cross-sectional assessment was conducted using routinely collected clinical information from medical records of patients who attended the service between October 2022 and September 2024. Data extraction combined review of paper and electronic records with verification through on-site clinical documentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over the two-year period, the clinic experienced a substantial increase in demand. In the first year, 274 patients received care, whereas in the second year this number rose to 657\u2014an increase of 239.7%. Overall, 931 patients attended the service. The majority of patients were female, with a mean age of 58 (\u00b1 11.1) years, and had the indeterminate form of CD (47.2%). A total of 630 patients (68.5%) underwent etiological treatment for the disease. Among these, 309 received prescriptions directly from the outpatient clinic, and 208 out of them (67.3%) experienced adverse drug reactions. The clinic provides care for the northern macro-region of Minas Gerais, encompassing 86 municipalities: 45 (52%) of these referred patients during the study period. Referral patterns highlighted contrasting municipal profiles: Montes Claros was the largest source of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings demonstrate the growing demand for specialized CD care and underscore the importance of dedicated services in regions where primary care lacks structured clinical pathways for CD management. The clinic offers not only access to etiological treatment and longitudinal follow-up but also a reproducible model for expanding equitable care for neglected diseases in other endemic settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0014488","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T17:44:01Z","timestamp":1783359841000},"page":"e0014488","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chagas Disease in northern Minas Gerais: Clinical and epidemiological features of patients at a pioneering specialized outpatient service"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8888-2957","authenticated-orcid":true,"given":"Luciano Freitas","family":"Fernandes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gl\u00e1ucia Rejanny","family":"Teixeira Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester Cerdeira","family":"Sabino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e2mara Fernandes","family":"Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayra Domingues","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Julia","family":"Torres Bonfim Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Clara","family":"de Jesus Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Beatriz","family":"Cardoso Sena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dardiane Santos","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariela Mota","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel","family":"Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"issue":"10115","key":"pntd.0014488.ref001","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0140-6736(17)31612-4","article-title":"Chagas disease","volume":"391","author":"JA P\u00e9rez-Molina","year":"2018","journal-title":"Lancet"},{"key":"pntd.0014488.ref002","first-page":"165","article-title":"Chagas disease, environment, participation, and the state","author":"JC Dias","year":"2001","journal-title":"Cad Saude Publica"},{"key":"pntd.0014488.ref003","first-page":"100681","article-title":"Prevalence of clinical forms of Chagas disease: a systematic review and meta-analysis - data from the RAISE study","volume":"30","author":"BR Nascimento","year":"2024","journal-title":"Lancet Reg Health Am"},{"issue":"11","key":"pntd.0014488.ref004","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0008782","article-title":"Challenges in the care of patients with Chagas disease in the Brazilian public health system: a qualitative study with primary health care doctors","volume":"14","author":"RF Damasceno","year":"2020","journal-title":"PLoS Negl Trop Dis"},{"issue":"3","key":"pntd.0014488.ref005","article-title":"Avalia\u00e7\u00e3o do conhecimento acerca do manejo cl\u00ednico de portadores da doen\u00e7a de Chagas em regi\u00e3o end\u00eamica no Brasil","volume":"21","author":"AM Ferreira","year":"2019","journal-title":"APS"},{"key":"pntd.0014488.ref006","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1590\/1414-462x201900030456","article-title":"Rea\u00e7\u00f5es adversas ao benzonidazol no tratamento da Doen\u00e7a de Chagas: revis\u00e3o sistem\u00e1tica de ensaios cl\u00ednicos randomizados e controlados","volume":"27","author":"AM Ferreira","year":"2019","journal-title":"Cad Saude Colet"},{"key":"pntd.0014488.ref007","volume-title":"Mortalidade por doen\u00e7a de Chagas (2010 a 2019)","author":"Brasil. 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